The United States of America as represented by the Secretary of the Army
대리인 / 주소
Morgan, Lewis &
인용정보
피인용 횟수 :
7인용 특허 :
218
초록▼
A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune response (e.g., humoral and/or cellu
A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a formulation containing antigen and adjuvant to intact skin of the animal or human. The efficiency of immunization may be enhanced by adding hydrating agents (e.g., liposomes), penetration enhancers, or occlusive dressings to the transcutaneous delivery system. This system may allow activation of Langerhans cells in the skin, migration of the Langerhans cells to lymph nodes, and antigen presentation.
대표청구항▼
We claim: 1. A method of inducing an immune response to at least one antigen comprising applying a formulation to hydrated skin of an organism, wherein the formulation comprises (i) at least one antigen which is derived from a pathogen and (ii) an adjuvant, wherein an effective amount of the at l
We claim: 1. A method of inducing an immune response to at least one antigen comprising applying a formulation to hydrated skin of an organism, wherein the formulation comprises (i) at least one antigen which is derived from a pathogen and (ii) an adjuvant, wherein an effective amount of the at least one antigen induces the immune response to the at least one antigen in the organism. 2. The method of claim 1, wherein the pathogen is selected from the group consisting of bacterium, virus, fungus and parasite. 3. The method of claim 1, wherein the antigen is selected from the group consisting of carbohydrate, glycolipid, glycoprotein, lipid, protein, lipoprotein, phospholipid, and polypeptide. 4. The method of claim 1, wherein the pathogen is a live or an attenuated live virus and the antigen is expressed by the live or attenuated live virus. 5. The method of claim 2, wherein the bacterium is anthrax. 6. The method of claim 2, wherein the virus is rabies. 7. The method of claim 1, wherein the adjuvant is selected from the group consisting of bacterial DNA, cytokines, chemokines and lipopolysaccharides. 8. The method of claim 1, wherein the adjuvant is an ADP-ribosylating exotoxin or toxoid thereof having adjuvant activity. 9. The method of claim 8, wherein the ADP-ribosylating exotoxin or toxoid thereof is selected from the group consisting of pertussis toxin, a pertussis toxin toxoid having adjuvant activity, cholera toxin (CT), a CT toxoid having adjuvant activity, an E. coli heat-labile enterotoxin (LT), an LT toxoid having adjuvant activity, diphtheria toxin (DT), a DT toxoid having adjuvant activity, Pseudomonas exotoxin A, and a Pseudomonas exotoxin A toxoid having adjuvant activity. 10. The method of claim 1, wherein the adjuvant is an ADP-ribosylating exotoxin B subunit from cholera toxin (CT). 11. The method of claim 1, wherein the adjuvant is selected from the group consisting of an ADP-ribosylating exotoxin in which ADP-ribosyl transferase activity is inactivated; an ADP-ribosylating exotoxin chemically conjugated to a carbohydrate, polypeptide, glycolipid, or glycoprotein antigen; an ADP-ribosylating exotoxin subunit chemically conjugated to a carbohydrate, polypeptide, glycolipid, or glycoprotein antigen; and, an ADP-ribosylating toxoid chemically conjugated to a carbohydrate, polypeptide, glycolipid, or glycoprotein antigen. 12. The method of claim 1, wherein the formulation is a cream or gel or emulsion or ointment or lotion or paste or solution or suspension. 13. The method of claim 1, wherein the formulation is applied with a patch. 14. The method of claim 1, wherein the formulation further comprises a dressing. 15. The method of claim 14, wherein the dressing is occlusive or non-occlusive. 16. The method of claim 7, wherein said cytokine is tumor necrosis factor alpha.
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이 특허에 인용된 특허 (218)
Digenis George A. (Lexington KY) Doll Walter J. (Lexington KY) Hawi Amale (Lexington KY), 3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer.
Limjuco Guadalupe A. (Scotch Plains NJ) Karkhanis Yashwant D. (Fanwood NJ) Carlo Dennis J. (South Amboy NJ), E. coli enterotoxin vaccine for veterinary and human use.
Limjuco Guadalupe A. (Scotch Plains NJ) Karkhanis Yashwant D. (Fanwood NJ) Carlo Dennis J. (South Amboy NJ), E. coli enterotoxin vaccine for veterinary and human use.
Chaudhary Nilabh (The Woodlands TX) Jayaraman Krishna (The Woodlands TX) Bodepudi Veeraiah (The Woodlands TX) Hogan Michael E. (The Woodlands TX), Amphipathic nucleic acid transporter.
Eppstein Jonathan A. ; Hatch Michael R., Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications.
Yuzhakov Vadim Vladimirovich ; Sherman Faiz Feisal ; Owens Grover David ; Gartstein Vladimir, Apparatus and method for using an intracutaneous microneedle array.
Midoux Patrick,FRX ; Erbacher Patrick,FRX ; Roche-Degremont Annie-Claude,FRX ; Monsigny Michel,FRX, Complexes of nucleic acid and polymer, their process of preparation and their use for the transfection of cells.
Colas AndrL. R. (Glashuetten DEX) Hadgraft Jonathan (Penarth GB7) Moffat Vivien L. C. (Elst NLX) Renauld Franck A. D. (Overijse BEX), Composition for enhancing drug permeation.
Curiel David T. (Chapel Hill NC) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX) Zatloukal Kurt (Vienna ATX) Plank Christian (Vienna ATX) Oberhauser Berndt, Composition for introducing nucleic acid complexes into higher eucaryotic cells.
Klipstein Frederick A. (Rochester NY) Engert Richard E. (Webster NY) Clements John D. (Pittsford NY), Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic Escherichia coli<.
Rajadhyaksha Vithal J. (27436 Esqina Mission Viejo CA 92691), Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers for physiological active a.
Rajadhyaksha Vithal J. (27436 Esquina Mission Viejo CA 92691), Compositions and method comprising heterocyclic compounds containing two heteroatoms as membrane penetration enhancers.
Hale Ron L. (Woodside CA) Lu Amy (Los Altos CA) Solas Dennis (San Francisco CA) Selick Harold E. (Belmont CA) Oldenburg Kevin R. (Fremont CA) Zaffaroni Alejandro C. (Atherton CA), Compositions and methods for enhanced drug delivery.
Elger Gordon (Huntingdon GBX) Leslie Stewart T. (Cambridge GBX) Malkowska Sandra T. A. (Landbeach GBX) Miller Ronald B. (Basel CHX) Neale Philip J. (Harston GBX), Controlled release pharmaceutical composition.
Jacques Steven L. (Somerville MA) McAuliffe Daniel J. (Revere MA) Blank Irvin H. (Belmont MA) Parrish John A. (Weston MA), Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
Ebert Charles D. (Salt Lake City UT) Venkateshwaran Srinivasan (Salt Lake City UT) Heiber Werner (Salt Lake City UT) Borsadia Suresh (Salt Lake City UT), Drug-containing adhesive composite transdermal delivery device.
Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT) Kost Joseph (Omer MA ILX) Langer Robert S. (Newton MA), Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers.
Chess Samuel (Newport Beach CA) McCullough Jerry L. (Irvine CA) Weinstein Gerald D. (Irvine CA), Enhancing the cutaneous penetration of pharmacologically active agents.
Wolff Jon A. (Madison WI) Duke David J. (Salem OR) Felgner Philip L. (Rancho Santa Fe CA), Expression of exogenous polynucleotide sequences cardiac muscle of a mammal.
Cullis Pieter R. (Vancouver CAX) Hope Michael J. (Vancouver CAX) Bally Marcel B. (Vancouver CAX), Extrusion technique for producing unilamellar vesicles.
Restifo Nicholas P. ; Rosenberg Steven A. ; Bennick Jack R. ; Bacik Igor ; Yewdell Jonathan W., Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at le.
Restifo Nicholas P. ; Rosenberg Steven A. ; Bennink Jack R. ; Bacik Igor ; Yewdell Jonathan W., Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at le.
Domenighini Mario,ITX ; Rappuoli Rino,ITX ; Pizza Mariagrazia,ITX ; Hol Wim, Immunogenic detoxified mutants of cholera toxin and of the toxin LT, their preparation and their use for the preparation of vaccines.
Berger Frank M. (190 E. 72nd St. New York NY 10021) Bona Constantin (New York NY) Lechevalier Mary P. (Piscataway NJ), Immunological adjuvant and process for preparing the same, pharmaceutical compositions, and process.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Induction of a protective immune response in a mammal by injecting a DNA sequence.
Kim Jung J. (Anyang-shi KRX) Lee Woo Y. (Anyang-shi KRX) Ahn Jong W. (Seoul KRX) Han Sang H. (Suwon-shi KRX), Medicinal adhesive for percutaneous administration.
Wagner Thomas E. ; Chen Xiaozhuo ; Li Yunsheng, Method for eliciting an immune response using a gene expression system that co-delivers an RNA polymerase with DNA.
Low Philip S. (West Lafayette IN) Horn Mark A. (West Lafayette IN) Heinstein Peter F. (West Lafayette IN), Method for enhanced transmembrane transport of exogenous molecules.
Helman Michael D. (Edison NJ) Lukacsko Alison B. (Robbinsville NJ) Re Thomas A. (Hazlet NJ) Zusi F. Christopher (Tonawanda NY), Method for enhancing transdermal penetration and compositions useful therein.
Powell Robert J. ; Lewis George K. ; Hone David M., Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same.
Bannon Yvonne B. (Naas IEX) Corish John (Leopardstown IEX) Corrigan Owen I. (Howth IEX) Geoghegan Edward J. (Athlone IEX) Masterson Joseph G. (Dublin IEX), Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said metho.
Askelof Per,SEX ; Carlin Nils,SEX ; Nilsson Bo,SEX ; Paulsson Agneta,SEX, Method of cultivating bacteria proteins that are expressed in a temperature regulated manner.
Papahadjopoulos Demetrios P. (78 Heathwood Williamsville NY 14221) Szoka ; Jr. Francis C. (375 Leroy Ave. Buffalo NY 14214), Method of encapsulating biologically active materials in lipid vesicles.
Szoka ; Jr. Francis C. (76 Summit St. Waltham MA 02154) Papahadjopoulos Demetrios P. (3170 Condit St. Lafayette CA 94549), Method of inserting DNA into living cells.
Garbe James E. (Inver Grove Heights MN) Northey Paul J. (Somerset WI) Peterson Timothy A. (Lino Lakes MN), Method of making a pressure sensitive skin adhesive sheet material.
Srinivasan Venkateshwaran ; David Fikstad ; Charles D. Ebert, Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions.
Cilento Rodolfo D. (North Brunswick NJ) Frank Margaret A. (Lawrenceville NJ) Fairbrother John E. (Wales NJ GBX) Freeman Frank M. (Lawrenceville NJ), Method of preparing adhesive dressings containing a pharmaceutically active ingredient.
Carson Dennis A. (Del Mar CA) Raz Eyal (San Diego CA), Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleoti.
Carson Dennis A. ; Raz Eyal ; Howell Meredith L., Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptide.
Hewitt Charles W. (698 Tranquility Turn Marlton NJ 08053) Black Kirby S. (13401 Sussex Pl. Santa Ana CA 92705), Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants.
Wolf Marcia K. (Silver Spring MD) Cassels Frederick J. (Ellicott City MD) Bell Brian A. (Clarksburg MD), Methods for production of antigens under control of temperature-regulated promotors in enteric bacteria.
Eppstein Deborah A. (Menlo Park CA) Felgner Philip L. (Los Altos CA) Gadek Thomas R. (Oakland CA) Jones Gordon H. (Cupertino CA) Roman Richard B. (Fairhope AL), N-www
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Brucks Richard M. ; Duvel Lane A., Non-ionic surfactant emulsion vehicles and their use for deposition of drug into and across skin.
De-chu C. Tang ; Donald H. Marks ; David T. Curiel ; Zhongkai Shi ; Kent Rigby van Kampen, Noninvasive genetic immunization, expression products therefrom and uses thereof.
Kasting Gerald B. (Wyoming OH) Massaro Ellen R. (Cincinnati OH) Smith Ronald L. (West Chester OH) Snyder William E. (Cincinnati OH), Penetrating topical pharmaceutical compositions.
Minaskanian Gevork (Irvine CA) Peck James V. (Costa Mesa CA) Nelson Eric L. (Newport Beach CA), Penetration enhancers for transdermal delivery of systemic agents.
Minaskanian Gevork (Irvine) Peck James V. (Costa Mesa) Rajadhyaksha Vithal J. (Mission Viejo CA), Penetration enhancers for transdermal delivery of systemic agents.
Petersen Robert V. (Murray UT) Hsu Tsung-Min (Union City CA) Lee Han-Chen (Salt Lake City UT) Christy Don (Albany NY), Percutaneous drug delivery system.
Larson Kenneth A. ; Campbell William R. ; Hepler Douglas I., Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use.
Loughrey Helen C. (Vancouver CAX) Cullis Pieter R. (Vancouver CAX) Bally Marcel B. (Bowen Island CAX) Choi Lewis S. L. (Burnaby CAX) Wong Kim F. (Vancouver CAX), Preparation of targeted liposome systems of a defined size distribution.
Hoffman Stephen L. ; Charoenvit Yupin ; Hedstrom Richard C. ; Doolan Denise L., Protective 17 KDA malaria hepatic and erythrocytic stage immunogen and gene.
Szoka ; Jr. Francis C. (45 Mendosa Ave. San Francisco CA 94116) Haensler Jean (117 ; Rue Principale 57540 Petite-Rosselle FRX), Self-assembling polynucleotide delivery system comprising dendrimer polycations.
Lenk Robert P. (Lambertville NJ) Fountain Michael W. (Griggstown NJ) Janoff Andrew S. (Yardley PA) Popescu Mircea C. (Plainsboro NJ) Weiss Steven J. (Hightstown NJ) Ginsberg Richard S. (Monroe Townsh, Stable plurilamellar vesicles.
Turner Josephine S. (Kettleby CAX) Murray D. Gary (Willowdale CAX) Zuccolin John D. (Stouffville CAX) Li Ruey S. (Thornhill CAX), Substance transfer system for topical application.
Wheatley Margaret A. (Arlington MA) Langer Robert S. (Somerville MA) Eisen Herman N. (Waban MA), System for delayed and pulsed release of biologically active substances.
Wick Steven M. (Mahtomedi MN) Schultz Helen J. (Falcon Heights MN) Nelson Gregory R. (Hudson WI) Mitra Amit K. (Woodbury MN) Berge Stephen M. (Shoreview MN), Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine.
Lee Hai Bang (Taejeon KRX) Shin Bung Chul (Taejeon KRX), Transdermal administration method of protein or peptide drug and its administration device thereof.
Grasela John C. ; Grasela Joseph E. ; Jubenville Robert M. ; McCloskey Joseph J., Transdermal delivery of medications using a combination of penetration enhancers.
Bello Gastone P. (Monmouth Beach NJ) Lyle John W. (Belmar NJ) Johnson Donald A. (Sea Girt NJ), Transdermal drug delivery device and method for its manufacture.
Nabel Elizabeth G. (Ann Arbor MI) Nabel Gary J. (Ann Arbor MI), Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor.
Quan Danyi ; Deshpanday Ninad A. ; Venkateshwaran Srinivasan ; Ebert Charles D., Triacetin as a penetration enhancer for transdermal delivery of a basic drug.
Beltz Gerald A. (Lexington MA) Marciani Dante J. (Hopkinton MA) Hung Chung-Ho (Milford MA) Kensil Charlotte A. (Milford MA), Vaccine comprising recombinant feline leukemia antigen and saponin adjuvant.
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