A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones h
A method of producing a processed kava product involves using an extraction solvent, such as liquid CO2, to preferentially extract different kavalactones from the source material at different rates. By controlling the extraction parameters and stopping the extraction before all of the kavalactones have been extracted or allowing the extracted kavalactones to be preferentially precipitated in one or more collection environments, a processed kava product can be produced that has a kavalactone distribution profile that can differ substantially from that of the source material. As a result, roots from a less desirable kava cultivar can be used to produce a processed kava product which has a kavalactone distribution profile that is similar to that of a highly desired cultivar. The kava paste can be further processed to produce a dry flowable powder suitable for use in, e.g., a tableting formula. A rapid dissolve tablet formulation for use in the delivery of kavalactones and other botanicals is also disclosed.
대표청구항▼
We claim: 1. A rapid dissolve botanical extract tablet for release of a botanical extract in the oral cavity, consisting essentially of (a) between about 5% to about 60% by weight of an extract of a botanical, wherein the botanical extract tablet comprises a botanical extract and wherein the botani
We claim: 1. A rapid dissolve botanical extract tablet for release of a botanical extract in the oral cavity, consisting essentially of (a) between about 5% to about 60% by weight of an extract of a botanical, wherein the botanical extract tablet comprises a botanical extract and wherein the botanical extract is obtained from Areca catechu, Piper betel, Ptychopetalum olacoides, Ilex paraguariensis, Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Panax quinquefolius, Panax ginseng, Curcuma longa, Lactuca virosa, Lactuca indica, Zingiber officinalis, Salix purpurea, Salix daphnoides, Prunus avium, Prunus cerasus, Pfaffia paniculata, Turnera diffusa, Epimedium species, Terrestris tribulus, Rhodiola rosea, Astragalus membranaceus, Eucommia ulmoides, Gastrodia elata, Uncaria rhyncophylla, or Coleus forskohlii; and wherein the botanical extract is obtained by extracting the botanical material using supercritical CO2 at a range of temperature of about 31째 C. to about 80째 C. and a range of pressure of about 1100 psi to about 8000 psi, and forming a dry flowable powder; and (b) between about 15% to about 60% by weight of a diluent; (c) between about 5% to about 15% by weight of a binder; and (d) between about 3% to about 40% by weight of a sweetener. 2. The tablet of claim 1, wherein the diluent is lactose, dextrose, sucrose, and mannitol. 3. The tablet of claim 1, wherein the binder is acacia, gum arabic, sodium alginate, extract of Irish moss, panwar gum, ghatti gum, mucilage of isapol husks, carboxymethylcellulose, hydroxyethylcellulose, methylcellulose, polyvinylpyrrolidone, VEEGUM짰, (magnesium aluminum silicate) larch arabogalactan, gelatin, carrageenan, and copolymers of maleic anhydride with ethylene or vinyl methyl ether. 4. The tablet of claim 1, wherein the sweetener is sugar, saccharin, sodium cyclamate, aspartame, or extract of Stevia. 5. The tablet of claim 1, further comprising between about 0. 001% to about 5% by weight of a flavoring. 6. The tablet of claim 5, wherein said flavoring is mint, cinnamon, citrus, ginger, cherry or grape. 7. The tablet of claim 1, further comprising between about 0. 5% to about 2% by weight of a coloring agent. 8. The tablet of claim 7, wherein said coloring is natural or synthetic. 9. The tablet of claim 1, further comprising between about 2% to about 10% by weight of a lubricant. 10. The tablet of claim 9, wherein said lubricant is talc, magnesium stearate, calcium stearate, stearic acid, hydrogenated vegetable oils, or carbowax. 11. The tablet of claim 1, further comprising between about 0. 15% to about 3% by weight of a disintegrant. 12. The tablet of claim 11, wherein said disintegrant is starches, clays, celluloses, algins, gums, crosslinked polymers, VEEGUM짰, (magnesium aluminum silicate) agar, bentonite, natural sponge, cation exchange resins, aliginic acid, guar gum, citrus pulp or sodium lauryl sulphate. 13. The tablet of claim 1, further comprising between about 0. 5% to about 5% of a buffer, wherein the buffer is mono-and di-sodium phosphates and borates, magnesium carbonate or combinations of magnesium and aluminum hydroxide. 14. A rapid dissolve botanical extract tablet for release of a botanical extract in the oral cavity, consisting essentially of (a) between about 5% to about 60% by weight of an extract of a botanical, and wherein the botanical extract tablet comprises a botanical extract and wherein the botanical extract is obtained from botanical plant material of Areca catechu, Piper betel, Ptychopetalum olacoides, Ilex paraguariensis, Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Panax quinquefolius, Panax ginseng, Curcuma longa, Lactuca virosa, Lactuca indica, Zingiber officinalis, Salix purpurea, Salix daphnoides, Prunus avium, Prunus cerasus, Pfaffia paniculata, Tumera diffusa, Epimedium species, Terrestris tribulus, Rhodiola rosea, Astragalus membranaceus, Eucommia ulmoides, Gastrodia elata, Uncaria rhyncophylla, or Coleus forskohlii; wherein the botanical extract is obtained by i) first processing the botanical plant material with CO2 at a range of pressure of between about 1100 psi to about 4500 psi at a range of temperature of between about 10째 C. to about 60째 C. for a time range of about 5 minutes to about 60 minutes, followed by rapid decompression to about 1 arm; ii) then extracting the botanical plant material using supercritical CO2 at a range of temperature of about 31째 C. to about 80째 C. and a range of pressure of about 1100 psi to about 8000 psi; and iii) forming a dry flowable powder; and (b) between about 15% to about 60% by weight of a diluent; (c) between about 5% to about 15% by weight of a binder; (d) between about 3% to about 40% by weight of a sweetener; (e) between about 0.001% to about 5% by weight of a flavoring; (f) between about 0.5% to about 2% by weight of a coloring; (g) between about 2% to about 10% by weight of a lubricant; and (h) between about 0.15% to about 3% by weight of a disintegrant. 15. The tablet of claim 1, wherein: the extract of botanical is present in an amount between about 5% to about 60% by weight; the diluent is lactose and is present in an amount between about 10% to about 40% by weight; and the binder is carboxymethylcellulose and is present in an amount between about 5% to about 15% by weight. 16. The tablet of claim 1, wherein the extract of botanical is present in an amount between about 5% to about 60% by weight; the diluent is lactose and is present in an amount between about 10% to about 40% by weight; the binder is acacia and is present in an amount between about 5% to about 15% by weight; and the sweetener is an extract of Stevia present in an amount between about 3% to about 40% by weight. 17. The tablet of claim 1, wherein the tablet dissolves orally in between about 2 seconds and about 180 seconds. 18. The tablet of claim 17, wherein the tablet dissolves orally in between about 3 seconds and about 120 seconds. 19. The tablet of claim 18, wherein the tablet dissolves orally in between about 5 seconds and about 60 seconds. 20. The tablet of claim 1, wherein said tablet has a shape selected from the group consisting of disk, cylinder, sphere and rectangular solid. 21. The tablet of claim 20, wherein said shape is a disk. 22. The tablet of claim 21 wherein said disk has a diameter of between about ⅛ inch to about one inch and a thickness of between about 0.08 inch to about 0.25 inch. 23. The tablet of claim 1, wherein prior to the extracting with supercritical CO2, the botanical material is processed with CO2 at a range of pressure of between about 1100 psi to about 4500 psi at a range of temperature of between about 100째 C. to about 60째 C., for a time range of about 5 minutes to about 60 minutes, followed by rapid decompression to about 1 arm.
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