An aseptic, continuous sampling arrangement used in a fluid transportation system, the arrangement including an elbow pipe and a septum cartridge. The sampling arrangement further including a needle, a tube, and a collection reservoir, arranged such that the collection reservoir is in fluid contact
An aseptic, continuous sampling arrangement used in a fluid transportation system, the arrangement including an elbow pipe and a septum cartridge. The sampling arrangement further including a needle, a tube, and a collection reservoir, arranged such that the collection reservoir is in fluid contact with the fluid transportation system. The sampling arrangement configured to create a non-laminar fluid flow region from which a continuous sample of fluid material is drawn.
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I claim: 1. A method of continuous aseptic sampling, comprising the steps of; (a) providing a fluid transportation structure that creates a non-laminar flow of a fluid in a sampling area within a fluid transportation system, the fluid transportation structure including an aperture located proximate
I claim: 1. A method of continuous aseptic sampling, comprising the steps of; (a) providing a fluid transportation structure that creates a non-laminar flow of a fluid in a sampling area within a fluid transportation system, the fluid transportation structure including an aperture located proximate the non-laminar sampling area; (b) providing a replaceable septum to seal the aperture of the fluid transportation structure and prevent the introduction of contaminates into the sampling area, the septum including an outer surface area and a plurality of guide holes covered by a cover piece that provides indication of used guide holes and unused guide holes; (c) providing a sterilized penetrating member, tubing, and a reservoir, wherein the penetrating member, tubing and reservoir are all in fluid communication with each other, the tubing and reservoir being sealed from environmental contaminates; (d) performing aseptic cleansing of the outer surface area and cover piece of the septum; (e) inserting the sterilized penetrating member into an unused guide hole wherein the guide hole directs the penetrating member into and through the septum, the septum constructed to further wipe and remove contaminates from the penetrating member during insertion; and (f) creating a pressure differential between the reservoir and the fluid transportation structure such that a sampling fluid continuously flows from the fluid transportation structure to the reservoir. 2. The method of claim 1, wherein the method of continuous aseptic sampling includes removing the penetrating member from the septum upon obtaining a sufficient sample size, the septum functioning to re-seal the sampling area to prevent entry of contaminates into the sampling area after removal of the penetrating member. 3. The method of claim 1, wherein the method of continuous aseptic sampling includes monitoring fluid flow and controlling flow rate by selectively introducing or increasing a restriction on the tubing. 4. The method of claim 3, wherein controlling the flow rate by introduction of a restriction is accomplished by use of a clamp. 5. The method of claim 3, wherein controlling the flow rate by introduction of a restriction is accomplished by use of a peristaltic pump. 6. A method of continuous aseptic sampling, comprising the steps of: (a) providing a fluid transportation structure having a portion configured therein to create a non-laminar fluid flow in a sampling region, and providing a sampling assembly having a penetrable member positioned in an opening located in the sampling region; and (b) obtaining an aseptic, continuous fluid sample from the non-laminar fluid flow in the sampling region, while simultaneously sealing the sampling region. 7. The method of claim 6, further including collecting the fluid sample from the non-laminar fluid flow in a collection reservoir. 8. The method of claim 7, further including cooling the fluid sample collected in the collection reservoir. 9. The method of claim 7, wherein the step of collecting the fluid sample in the collection reservoir includes extending a length of tubing between the penetrable member and the collection reservoir, and creating a pressure differential between the collection reservoir and the fluid transportation structure to provide aseptic, continuous fluid communication between the fluid transportation structure and the collection reservoir. 10. The method of claim 6, further including retrofitting an existing fluid transportation system with the fluid transportation structure having the portion configured to create the non-laminar fluid flow. 11. The method of claim 10, wherein the step of retrofitting includes fitting a pipe having an aperture and an angular configuration to the existing fluid transportation system such that fluid from the system flows through the pipe. 12. The method of claim 11, further including securing the penetrable member within the aperture of the pipe. 13. The method of claim 6, wherein the step of obtaining a continuous, aseptic fluid sample includes inserting a sampling body into and through the penetrable member to contact the non-laminar fluid flow created in the sampling region. 14. The method of claim 6, wherein the step of obtaining the aseptic, continuous fluid sample from the non-laminar fluid flow in the sampling region includes obtaining a milk sample from a milk processing system. 15. The method of claim 14, further including detecting microbial contamination in the milk sample for purposes of dairy herd management. 16. The method of claim 14, further including testing the milk sample for the purpose of monitoring mastitis in a dairy herd. 17. The method of claim 16, further including regulating the rate of the fluid sample collection with a flow control device.
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이 특허에 인용된 특허 (9)
Galloway Edwin J. (Menasha WI), Aseptic fluid transfer apparatus and methods.
Newberg Douglas A. (Annapolis MD) Pavlin Vjekoslav (Adelphi MD) Newberg Richard R. (Royal Oak MD) Yang Jackson C. S. (Silver Spring MD), Automated sample extractor or feeder/inoculator for bioreactors and similar equipment.
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