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Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08G-059/00
  • C08G-065/00
  • C08G-067/02
  • C08G-067/00
출원번호 US-0298151 (2002-11-15)
발명자 / 주소
  • Heller,Jorge
  • Ng,Steven Y.
출원인 / 주소
  • A.P. Pharma, Inc.
대리인 / 주소
    Heller Ehrman LLP
인용정보 피인용 횟수 : 6  인용 특허 : 52

초록 ▼

Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block copolymers have both hydrophilic

대표청구항 ▼

What is claimed is: 1. A poly(ortho ester) of formula I: where n is an integer of at least 5; R is a bond,--(CH2)a--, or--(CH2) b--O--(CH2)c--, where a is an integer of 1 to 10, and b and c are independently integers of 1 to 5; Ra is a C1-C4 alkyl; Rb is hydrogen or a C1-C2 alkyl; and each A is

이 특허에 인용된 특허 (52)

  1. Churchill Jeffrey R. (Northwich GBX) Hutchinson Francis G. (Lymm GBX), Biodegradable amphipathic copolymers.
    상세보기
  2. Fuisz Richard C. (Great Falls VA), Biodegradable controlled release flash flow melt-spun delivery system.
    상세보기
  3. Sparer, Randall V.; Pogany, Stefano A., Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal.
    상세보기
  4. Heller Jorge (Woodside CA) Ng Steve Y. W. (San Francisco CA), Bioerodible polymers for solid controlled release pharmaceutical compositions.
    상세보기
  5. Ng Steve Y. W. (San Francisco CA) Heller Jorge (Woodside CA), Bioerodible polymers useful for the controlled release of therapeutic agents.
    상세보기
  6. Ng Steve Y. W. (San Francisco CA) Heller Jorge (Woodside CA), Bioerodible polymers useful for the controlled release of therapeutic agents.
    상세보기
  7. Ng Steve Y. W. ; Heller Jorge, Bioerodible polymers, compositions and therapeutic method.
    상세보기
  8. Ng, Steven Y.; Heller, Jorge, Bioerodible polyorthoesters containing amine groups.
    상세보기
  9. Ng, Steven Y.; Heller, Jorge, Bioerodible polyorthoesters from dioxolane-based diketene acetals.
    상세보기
  10. Heller Jorge (Palo Alto CA) Baker Richard W. (Bend OR), Bioerodible system for delivering drug manufactured from poly(carboxylic acid).
    상세보기
  11. Heller Jorge (Palo Alto CA), Controlled drug release composition.
    상세보기
  12. Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
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  13. Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
    상세보기
  14. Chandrashekar Bhagya L. ; Zhou Mingxing ; Jarr Eileen M. ; Dunn Richard L., Controlled release liquid delivery compositions with low initial drug burst.
    상세보기
  15. Heller Jorge (Palo Alto CA) Baker Richard W. (Bend OR), Device for delivery of useful agent.
    상세보기
  16. Choi ; Nam Sok ; Heller ; Jorge, Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates).
    상세보기
  17. Choi Nam S. (Seoul CA KRX) Heller Jorge (Palo Alto CA), Erodible agent releasing device comprising poly(orthoesters) and poly(orthocarbonates).
    상세보기
  18. Berde Charles B. ; Langer Robert S. ; Curley Joanne ; Castillo Jenny, Formulations and methods for providing prolonged local anesthesia.
    상세보기
  19. Yewey Gerald L. ; Krinick Nancy L. ; Dunn Richard L. ; Radomsky Michael L. ; Brouwer Gerbrand ; Tipton Arthur J., Liquid delivery compositions.
    상세보기
  20. Heller Jorge (Woodside CA) Skinner Wilfred A. (Portola Valey CA) Saito Kenichiro (Menlo Park CA) Satoh Susumu (Osaka JPX), Method for percutaneously administering physiologically active agents.
    상세보기
  21. Tormala Pertti O. (Tampere FIX) Miettinen-Lahde Saila S. (Raiso FIX), Method for preparing matrix-type pharmaceutical compositions through ultrasonic means to accomplish melting.
    상세보기
  22. Heller Jorge (Woodside CA) Penhale Donald W. H. (Menlo Park CA) Ng Steve Y. (San Francisco CA), Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product.
    상세보기
  23. Heller Jorge (Woodside CA) Penhale Donald W. H. (Menlo Park CA) Ng Steve Y. (San Francisco CA), Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product.
    상세보기
  24. Domb Abraham J.,ILX ; Gref Ruxandra,FRX ; Minamitake Yoshiharu,JPX ; Peracchia Maria Teresa,ITX ; Langer Robert S., Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers.
    상세보기
  25. Choi Nam S. (Seoul CA KRX) Heller Jorge (Palo Alto CA), Novel orthoester polymers and orthocarbonate polymers.
    상세보기
  26. Heller Jorge ; Ng Steven Y., PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers.
    상세보기
  27. Ragavan Vanaja V. ; DiPiano Gerrianne M., Pharmaceutical preparations and methods for their administration.
    상세보기
  28. Yokoyama Masayuki (Matsudo JPX) Sakurai Yasuhisa (Tokyo JPX) Okano Teruo (Ichikawa JPX) Kataoka Kazunori (Kashiwa JPX), Physical trapping type polymeric micelle drug preparation.
    상세보기
  29. Yokoyama Masayuki (Matsudo JPX) Sakurai Yasuhisa (Tokyo JPX) Okano Teruo (Ichikawa JPX) Kataoka Kazunori (Kashiwa JPX), Physical trapping type polymeric micelle drug preparation.
    상세보기
  30. Lyle M. Bowman ; Santosh Kumar Chandrasekaran ; Rajesh Patel ; Hoa Vinh Vo, Plasticized bioerodible controlled delivery system.
    상세보기
  31. Choi ; Nam Sok ; Heller ; Jorge, Poly(carbonates).
    상세보기
  32. Heller Jorge (Woodside CA) Penhale Donald W. H. (Menlo Park CA) Ng Steve Y. (San Francisco CA), Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols.
    상세보기
  33. Heller Jorge (Woodside CA) Penhale Donald W. H. (Menlo Park CA), Polyacetal hydrogels formed from divinyl ethers and polyols.
    상세보기
  34. Heller Jorge (Woodside CA) Penhale Donald W. H. (Menlo Park CA), Polyacetal hydrogels formed from divinyl ethers and polyols.
    상세보기
  35. Totakura Nagabhushanam (North Haven CT) Shalaby Shalaby W. (Anderson SC), Polymeric composition.
    상세보기
  36. Heller Jorge (Woodside CA) Ng Steve Y. W. (San Francisco CA) Penhale Donald W. H. (Menlo Park CA), Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages.
    상세보기
  37. Heller Jorge (Woodside CA) Ng Steve Y. W. (San Francisco CA) Penhale Donald W. H. (Menlo Park CA), Polymers containing carboxy-ortho ester and ortho ester linkages.
    상세보기
  38. Heller Jorge (Woodside CA), Polymers containing pendant acid functionalities and labile backbone bonds.
    상세보기
  39. Heller Jorge (Woodside CA), Polymers containing pendant acid functionalities and labile backbone bonds.
    상세보기
  40. Heller Jorge (Palo Alto CA) Helwing Robert F. (Sunnyvale CA) Penhale Donald W. (Cupertino CA), Polymers of di- (and higher functionality) ketene acetals and polyols.
    상세보기
  41. Heller Jorge ; Ng Steven Y., Polymers with controlled physical state and bioerodibility.
    상세보기
  42. Ng Steven Y. (San Francisco CA) Penhale Donald W. (Cupertino CA) Heller Jorge (Woodside CA), Preparation of ketene acetals.
    상세보기
  43. Helwing Robert F. (San Jose CA), Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals.
    상세보기
  44. Bezwada Rao S. (Whitehouse Station NJ) Jamiolkowski Dennis D. (Long Valley NJ) Shalaby Shalaby W. (Lebanon NJ), Segmented copolymers of e 상세보기
  • Ng, Steven Y.; Shen, Hui-Rong; Heller, Jorge, Semi-solid delivery vehicle and pharmaceutical compositions.
    상세보기
  • Choi ; Nam S. ; Heller ; Jorge, Structured orthoester and orthocarbonate drug delivery devices.
    상세보기
  • Heller Jorge (Palo Alto CA) Baker Richard W. (Bend OR), System for delivering agent to environment of use over prolonged time.
    상세보기
  • Cekoric ; Mark E. ; Loring ; Robert M. ; Ludwico ; William A., Talc-based external mold release agent for polyurethane foams.
    상세보기
  • Roorda Wouter E. (Newark CA) Ehnow Fred (Mountain View CA), Viscous suspensions of controlled-release drug particles.
    상세보기
  • Sakurai Yasuhisa (Tokyo JPX) Okano Teruo (Chiba JPX) Kataoka Kazunori (Chiba JPX) Yamada Noriko (Tokyo JPX) Inoue Shohei (Tokyo JPX) Yokoyama Masayuki (Tokyo JPX), Water soluble high molecular weight polymerized drug preparation.
    상세보기
  • Sakurai Yasuhisa (Tokyo JPX) Okano Teruo (Chiba-ken JPX) Kataoka Kazunori (Chiba-ken JPX) Yamada Noriko (Tokyo JPX) Inoue Shohei (Tokyo JPX) Yokoyama Masayuki (Tokyo JPX), Water soluble high molecular weight polymerized drug preparation.
    상세보기
  • Heller Jorge (Woodside CA), Water soluble polyesters.
    상세보기

    • 이 특허를 인용한 특허 (6)

    1. Hobot, Christopher M.; Benz, Michael E.; Hildebrand, Keith R.; Pudil, Bryant J., Baclofen formulation in a polyorthoester carrier.
      상세보기
    2. Hobot, Christopher M.; Benz, Michael E.; Hildebrand, Keith R.; Pudil, Bryant J., Benzodiazepine formulation in a polyorthoester carrier.
      상세보기
    3. Hobot, Christopher M.; Benz, Michael E.; Hildebrand, Keith R.; Pudil, Bryant J., Bupivacaine formulation in a polyorthoester carrier.
      상세보기
    4. Alkatout, Julie A.; Benz, Michael Eric; Sparer, Randall V., Poly(orthoester) polymers, and methods of making and using same.
      상세보기
    5. Alkatout, Julie A.; Benz, Michael Eric; Sparer, Randall V., Poly(orthoester) polymers, and methods of making and using same.
      상세보기
    6. Brown, Malcolm, Tunable segmented polyacetal.
      상세보기

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