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Matrices for drug delivery and methods for making and using the same 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
출원번호 US-0838423 (2004-05-04)
발명자 / 주소
  • Babich,John W.
  • Zubieta,Jon
  • Bonavia,Grant
출원인 / 주소
  • Molecular Insight Pharmaceuticals, Inc.
대리인 / 주소
    Foley &
인용정보 피인용 횟수 : 8  인용 특허 : 30

초록

In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme

대표청구항

What is claimed is: 1. A medical article comprising: a. an inorganic-based sol-gel matrix that is biocompatible; and, b. a first reaction center encapsulated in said matrix, wherein upon placing said article comprising said biocompatible matrix in contact with tissue and/or fluids of a subject, s

이 특허에 인용된 특허 (30)

  1. Burke Philip J. (Charlton GBX) Dowell Robert I. (Congleton MD GBX) Mauger Anthony B. (Kensington MD) Springer Caroline J. (London GBX), Chemical compounds.
  2. Burke Philip John,GBX ; Dowell Robert Ian,GBX ; Mauger Anthony Brian ; Springer Caroline Joy,GBX, Chemical compounds.
  3. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Lev Ovadia (Jerusalem ILX), Chromatography processes using doped sol gel glasses as chromatographic media.
  4. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsul.
  5. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in.
  6. Sabel Bernhard A. (Munich MA DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Somerville MA), Controlled drug delivery system for treatment of neural disorders.
  7. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Delivery of biologically active molecules using cells contained in biocompatible immunoisolatory capsules.
  8. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Braun Sergei (Jerusalem ILX) Zusman Rivka (Jerusalem ILX), Doped sol-gel glasses for obtaining chemical interactions.
  9. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Braun Sergei (Jerusalem ILX) Zusman Rivka (Jerusalem ILX), Doped sol-gel glasses for obtaining chemical interactions.
  10. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Braun Sergei (Jerusalem ILX) Zusman Riyka (Jerusalem ILX), Doped sol-gel glasses for obtaining chemical interactions.
  11. Avnir David,ILX ; Ottolenghi Michael,ILX ; Braun Sergei,ILX ; Zusman Rivka,ILX, Doped sol-gel glasses for obtaining chemical interactions.
  12. Hubbell Jeffrey A. (Concord MA) Pathak Chandrashekhar P. (Austin TX) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hossainy Syed F. A. (Austin TX), Gels for encapsulation of biological materials.
  13. Swain Philip A. ; Schad Victoria Carol ; Greenstein Julia Lea ; Exley Mark Adrian ; Fox Barbara Saxton ; Powers Stephen P. ; Gefter Malcolm L., Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation.
  14. Harris Curtis C. ; Cole Katharine H. ; Lechner John F. ; Reddel Roger,AUX, Human liver epithelial cell lines.
  15. Wedekind Frank,DEX ; Daser Adelheid,DEX ; Tischer Wilhelm,DEX, Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosilox.
  16. Ducheyne Paul ; Radin Shulamith ; Santos Erick Manuel, Incorporation of biological molecules into bioactive glasses.
  17. Easton Thomas G. (Coram NY) Reich Edward (Setauket NY), Injection/activation apparatus.
  18. Dionne Keith E. ; Hegre Orion D. ; Flanagan Thomas R. ; Hazlett Tyrone F. ; Doherty Edward J., Inner supported biocompatible cell capsules.
  19. Dionne Keith E. ; Hegre Orion D. ; Flanagan Thomas R. ; Hazlett Tyrone F. ; Doherty Edward J., Inner-supported, biocompatible cell capsules.
  20. Holland Laura M. (Providence RI) Hammang Joseph P. (Barrington RI) Rudnick Seth A. (Barrington RI) Lysaght Michael J. (E. Greenwich RI) Dionne Keith E. (Rehoboth MA), Method for implanting encapsulated cells in a host.
  21. Whitmire David R., Method for rapid enzymatic alcohol removal.
  22. Vallee Bert L. (Brookline MA) Keung Wing-Ming (Wayland MA), Method for the inhibition of ALDH-I useful in the treatment of alcohol dependence or alcohol abuse.
  23. Naughton Brian A. ; Naughton Gail K., Methods of use of a three-dimensional liver cell and tissue culture system.
  24. Lihme Allan Otto Fog,DKX ; B.o slashed.g-Hansen Thorkild Christian,DKX ; Nielsen Claus Schafer,DKX, Permeable hollow particles having an outer shell of mechanically rigid porous material.
  25. Burke Philip John (Charlton GBX) Dowell Robert Ian (Congleton GBX) Mauger Anthony Brian (Kensington MD), Process for antibody directed enzyme prodrug therapy.
  26. Frank Bruce H. (Indianapolis IN) Prouty Walker E. (Indianapolis IN) Heiney Richard E. (Greenwood IN) Walden Mark R. (Indianapolis IN), Process for transforming a human insulin precursor to human insulin.
  27. Burke Philip J. (Charlton GBX) Dowell Robert I. (Congleton GBX) Mauger Anthony B. (Kensington MD) Springer Caroline J. (London GBX), Prodrugs for antibody directed enzyme prodrug therapy.
  28. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Lev Ovadia (Jerusalem ILX), Qualitative and quantitative processes for reactive chemicals in liquids using doped sol-gel glasses.
  29. Chari Ravi V. J. ; Goldmakher Viktor S. ; Blattler Walter A., Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs.
  30. Blum Kenneth (San Antonio TX) Trachtenberg Michael C. (Houston TX), Treatment of cocaine addiction.

이 특허를 인용한 특허 (8)

  1. Sertchook, Hanan; Toledano, Ofer; Bar-Simantov, Haim, Compositions for the treatment of rosacea.
  2. Toledano, Ofer; Sertchook, Hanan; Loboda, Natalia; Bar-Simantov, Haim; Shapiro, Leora; Abu-Reziq, Raed, Compositions for topical application comprising a peroxide and retinoid.
  3. Novak, Paige J.; Arnold, William A.; Surdo, Erin M., Membranes for wastewater-generated energy and gas.
  4. Toledano, Ofer; Sertchook, Hanan; Loboda, Natalia; Bar-Simantov, Haim, Metal oxide coating of water insoluble ingredients.
  5. Hauer,Bernhard; Habicher,Tilo; Schmid,Rolf; Maurer,Steffen Christian; Urlacher,Vlada Beniaminovna; Schulze,Holger; Huber,Norbert; Bachmann,Till T., Method for producing a hydroxylation catalyst and the use thereof.
  6. Wackett, Lawrence P.; Aksan, Alptekin; Sadowsky, Michael J; Reategui, Eduardo; Kasinkas, Lisa, Silica encapsulated biomaterials.
  7. Reategui, Eduardo; Kasinkas, Lisa; Aksan, Alptekin, Silica-matrix forming compositions, materials formed therefrom, and methods of using the same.
  8. Novak, Paige J.; Arnold, William Alan; Aksan, Alptekin, System and membrane for wastewater-generated energy and gas.
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