[특허]Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase

[미국특허] Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07K-016/00
출원번호	US-0373579 (2003-02-24)
발명자 / 주소	Morr챕,D. James McCarty,NaMi Morr챕,Dorothy Chueh,Pin Ju
출원인 / 주소	Purdue Research Foundation
대리인 / 주소	Greenlee, Winner &
인용정보	피인용 횟수 : 7 인용 특허 : 24

초록 ▼

Compositions and methods for diagnosis of neoplastic tissue are described. Monoclonal antibodies which specifically recognize the tumor cell specific NADH:protein thiol reductase and the hybridoma cell lines which produce them are provided. Also provided are diagnostic and immunohistological assays

대표청구항 ▼

We claim: 1. A monoclonal antibody, specific for a disulfide-thiol interchange/NADH oxidese protein of a cell surface protein (tNOX), wherein said tNOX occurs in serum, in urine and on surfaces of neoplastic cells of a human or animal with a neoplastic disorder and does not occur in serum, urine and cell surfaces of a human or animal without a neoplastic disorder, and wherein said monoclonal antibody is produced by hybridoma line 12.1, American Type Culture collection Accession No. PTA-4206.

이 특허에 인용된 특허 (24) 인용/피인용 타임라인 분석

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Chatterjee Malaya ; Foon Kenneth A. ; Chatterjee Sunil K., Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1.
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Morre D. James (West Lafayette IN) Byrn Steven R. (West Lafayette IN) Crane Frederick L. (West Lafayette IN) Morre Dorothy M. (West Lafayette IN), NADH oxidase assay for neoplasia determination.
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Goldenberg Milton D. (11837 Gainsborough Rd. Potomac MD 20854), Tumor localization and therapy with labeled anti-CEA antibody.
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Goldenberg Milton D. (11837 Gainsborough Rd. Potomac MD 20854), Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers.
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A	생활필수품
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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase 원문보기