Process and composition for high efficacy teeth whitening
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-007/16
A61K-007/20
출원번호
US-0125787
(2002-04-17)
발명자
/ 주소
Orlowski,Jan A.
Butler,David V.
출원인 / 주소
Scientific Pharmaceuticals, Inc.
대리인 / 주소
Knobbe, Martens, Olson &
인용정보
피인용 횟수 :
1인용 특허 :
76
초록▼
Disclosed is a process and composition for bleaching teeth made up of two components blended together before each application. The method and composition offers faster results while significantly reducing the possibility of user discomfort. One of said components comprises carbamide peroxide, the ot
Disclosed is a process and composition for bleaching teeth made up of two components blended together before each application. The method and composition offers faster results while significantly reducing the possibility of user discomfort. One of said components comprises carbamide peroxide, the other contains salts and hydroxides and/or oxides of metals belonging to the first or second group of the Periodic Table which stimulate the generation of radical oxygen. In one embodiment, the first part comprises up to 50% water by weight and optionally comprises a stabilizer. In some embodiments, the first component is substantially colorless and the second component comprises a dye indicator which discolors or loses color when exposed to radical oxygen generated by the mixing of the two components.
대표청구항▼
What is claimed is: 1. A composition for whitening teeth comprising: a first component in the form of a suspension or solution comprising about 5% to 34% carbamide peroxide and up to 50% water, and at least one stabilizer selected from the group consisting of sodium silicate, 8-hydroxyquinoline, so
What is claimed is: 1. A composition for whitening teeth comprising: a first component in the form of a suspension or solution comprising about 5% to 34% carbamide peroxide and up to 50% water, and at least one stabilizer selected from the group consisting of sodium silicate, 8-hydroxyquinoline, sodium stannate, oxalic-bis (cyclohexylidenehydrazie), amino-trismethylene-phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, sodium pyrophosphate, and 1-hydroxyethylidene1,1-phosphonic acid, said first component having a pH of about 3.0 to 7.5; and a second component in the form of an aqueous gel or paste comprising one or more alkali materials selected from the group consisting of: oxides of metals belonging to the first or second group of the Periodic Table, hydroxides of metals belonging to the first or second group of the Periodic Table, and sodium, potassium, calcium, or magnesium salts of weak acids; said second component having a pH of about 8.0 to 12; wherein admixing of said first and second components prior to applying the composition to teeth provides the composition for whitening teeth having a pH of about 8.0 to 12. 2. The composition of claim 1, wherein the first component comprises more than 5% water. 3. The composition of claim 1, wherein the first component, the second component, or both the first and second components further comprise one or more thickening agents. 4. The composition of claim 3, wherein the one or more thickening agents are independently selected from the group consisting of polyacrylic acid, polyacrylic acid salts, amine crosslinked polyacrylic acid, natural gums, gelatin, starch, cellulose derivatives, and polyalkalene oxides. 5. The composition of claim 1, wherein the composition further comprises sodium fluoride, stannous fluoride, or sodium monofluorophosphate. 6. The composition of claim 1, wherein the ratio of mixing of the first component to the second component is 1:1 by volume. 7. The composition of claim 1, wherein said alkali materials are selected from the group consisting of calcium oxide, sodium hydroxide, potassium hydroxide, potassium bicarbonate, sodium acetate, sodium carbonate, sodium bicarbonate, sodium benzoate, sodium acrylate, sodium methacrylate, sodium gluconate, calcium carbonate, magnesium carbonate, calcium phosphates, calcium bicarbonate, calcium gluconate, and calcium silicate. 8. A composition for whitening teeth comprising: a first component in the form of a suspension or solution, said first component having a pH of about 3.0 to 7.5 and comprising about 15% to 34% carbamide peroxide, up to about 50% water, and at least one stabilizer, selected from the group consisting of sodium silicate, 8-hydroxyquinoline, sodium stannate, oxalic-bis (cyclohexylidenehydrazide), amino-trismethylene-phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, sodium pyrophosphate, and 1-hydroxyethylidene-1,1-phosphonic acid, said first component being colorless; and a second component in the form of an aqueous gel or paste, said second component having a pH of about 8.0 to 12 and comprising one or more alkali materials selected from the group consisting of oxides of metals belonging to the first or second group of the Periodic Table, hydroxides of metals belonging to the first or second group of the Periodic Table, and sodium, potassium, calcium, or magnesium salts of weak acids, and a colored dye indicator which gradually discolors or loses color when reacted with a radical oxygen; wherein admixing of said first and second components prior to applying the composition to teeth provides the composition for whitening teeth having a pH of about 8.0 to 12. 9. The composition of claim 8, wherein the first component comprises more than 5% water. 10. The composition of claim 8, wherein the first component, the second component, or both the first and second components further comprise one or more thickening agents. 11. The composition of claim 8, wherein the one or more thickening agents are independently selected from the group consisting of polyacrylic acid, polyacrylic acid salts, amine crosslinked polyacrylic acid, natural gums, gelatin, starch, cellulose derivatives, and polyalkalene oxides. 12. The composition of claim 8, wherein the composition further comprises sodium fluoride, stannous fluoride, or sodium monofluorophosphate. 13. The composition of claim 8, wherein the ratio of mixing of the first component to the second component is 1:1. 14. The composition of claim 8, wherein said alkali materials are selected from the group consisting of: calcium oxide, sodium hydroxide, potassium hydroxide, potassium bicarbonate, sodium acetate, sodium carbonate, sodium bicarbonate, sodium benzoate, sodium acrylate, sodium methacrylate, sodium gluconate, calcium carbonate, magnesium carbonate, calcium phosphates, calcium bicarbonate, calcium gluconate, and calcium silicate. 15. A process for whitening teeth, comprising: mixing first and second components to form a tooth whitening composition, the first component comprising about 15% to 34% carbamide perioxide and up to 50% water,and at least one stabilizer selected from the group consisting of sodium silicate, 8-hydroxyquinoline, sodium stannate, oxalic-bis (cyclohexylidenehydrazide), amino-trismethylene-phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, sodium pyrophosphate, and 1-hydroxyethylidene-1,1,-phosphonic acid, said first component having a pH of about 3.0 to 7.5; and the second component comprising one or more alkali materials selected from the group consisting of calcium oxide, sodium hydroxide, potassium hydroxide, potassium bicarbonate, sodium acetate, sodium carbonate, sodium bicarbonate, sodium benzoate, sodium acrylate, sodium methacrylate, sodium gluconate, calcium carbonate, magnesium carbonate, calcium phosphates, calcium bicarbonate, calcium gluconate, and calcium silicate, said second component having a pH of about 8.0 to 10; and contacting one or more teeth with the tooth whitening composition for about 10-60 minutes or less. 16. The process according to claim 15, wherein contacting one or more teeth with the tooth whitening composition occurs for about 20 minutes. 17. The process according to claim 15, further comprising placing the tooth whitening composition into a flexible tray or form shaped to fit over one or more teeth in a human mouth prior to contacting said teeth with the composition. 18. The process according to claim 15, wherein the second component further comprises a dye indicator and the process further comprises separating the composition from the teeth after the dye indicator discolors or loses color. 19. The process according to claim 18, wherein the first part is colorless. 20. The process of claim 15, wherein the first component comprises more than 5% water. 21. The composition of claim 1, wherein said one or more alkali materials include one or more alkali materials selected from the group consisting of bicarbonate, acetate, carbonate, benzoate, acrylate, methacrylate, gluconate, phosphate, and silicate salts. 22. The composition of claim 8, wherein said one or more alkali materials include one or more alkali materials selected from the group consisting of bicarbonate, acetate, carbonate, benzoate, acrylate, methacrylate, gluconate, phosphate, and silicate salts. 23. A composition for whitening teeth comprising: a first component in the form of a suspension or solution comprising about 5% to 34% carbamide peroxide and up to 50% water, and at least one stabilizer selected from the group consisting of sodium silicate, 8-hydroxyquinoline, sodium stannate, oxalic-bis (cyclohexylidenehydrazide), amino-trismethylene-phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, sodium pyrophosphate, and 1-hydroxyethylidene-1,1-phosphonic acid, said first component having a pH of about 3.0 to 7.5; and a second component in the form of an aqueous gel or paste comprising one or more alkali materials selected from the group consisting of sodium, potassium, magnesium, and calcium salts of weak acids, oxides of sodium, potassium, magnesium, and calcium; and hydroxides of sodium, potassium, magnesium, and calcium; said second component having a pH about 8.0; wherein admixing of said first and second components prior to applying the composition to the teeth provides the composition for whitening teeth having a pH of about 8.0 to 12. 24. The composition of claim 23, wherein said one or more alkali materials include one or more alkali materials selected from the group consisting of bicarbonate, acetate, carbonate, benzoate, acrylate, methacrylate, gluconate, phosphate, and silicate salts. 25. The composition of claim 23, wherein the first component comprises more than 5% water. 26. The composition of claim 23, wherein the first component, the second component, or both the first and second components further comprise one or more thickening agents. 27. The composition of claim 26, wherein the one or more thickening agents are independently selected from the group consisting of polyacrylic acid, polyacrylic acid salts, amine crosslinked polyacrylic acid, natural gums, gelatin, starch cellulose derivatives, and polyalkylene oxides. 28. The composition of claim 23, wherein the composition further comprises sodium fluoride, stannous fluoride or sodium monofluorophosphate. 29. The composition of claim 23, wherein a ratio of mixing of the first component to the second component is about 1:1 by volume. 30. The composition of claim 23, wherein said alkali materials are selected from the group consisting of calcium oxide, sodium hydroxide, potassium hydroxide, potassium bicarbonate, sodium acetate, sodium carbonate, sodium bicarbonate, sodium benzoate, sodium acrylate, sodium methacrylate, sodium gluconate, calcium carbonate, magnesium carbonate, calcium phosphates, calcium bicarbonate, calcium gluconate, and calcium silicate. 31. A composition for whitening teeth comprising: a first component in the form of a suspension or solution, said first component having a pH of about 3.0 to 7.5 and comprising about 15% to 34% carbamide peroxide, up to about 50% water, and at least one stabilizer selected from the group consisting of sodium silicate, 8-hydroxyquinoline, sodium stannate, oxalic-bis (cyclohexylidenehydrazide), amino-trismethylene-phosphonic acid, 2-phosphonobutane-1,2,4-tricarboxylic acid, sodium pyrophosphate, and 1-hydroxyethylidene-1,1-phosphonic acid, said first component being colorless; and a second component in the form of an aqueous gel or paste, said second component having a pH above 8.0 and comprising a colored dye indicator which gradually discolors or loses color when reacted with a radical oxygen, and one or more alkali materials selected from the group consisting of sodium, potassium, magnesium, and calcium salts of weak acids, oxides of sodium, potassium, magnesium, and calcium, and hydroxides of sodium, potassium, magnesium, and calcium; wherein admixing of said first and second components prior to applying the compositon to teeth provides the composition for whitening teeth having a pH of about 8.0 to 12. 32. The composition of claim 31, wherein said one or more alkali materials include one or more alkali materials selected from the group consisting of bicarbonate, acetate, carbonate, benzoate, acrylate, methacrylate, gluconate, phosphate, and silicate salts. 33. The composition of claim 31, wherein the first component comprises more than 5% water. 34. The composition of claim 31, wherein the first component, the second component, or both the first and second components further comprise one or more thickening agents. 35. The composition of claim 31, wherein the one or more thickening agents are independently selected from the group consisting of polyacrylic acid, polyacrylic acid salts, amine crosslinked polyacrylic acid, natural gums, gelatin, starch, cellulose derivativs, and polyalkylene oxides. 36. The composition of claim 31, wherein the composition further comprises sodium fluoride, stannous fluoride, or sodium monofluorophosphate. 37. The composition of claim 31, wherein a ratio of mixing of the first component to the second component is 1:1. 38. The composition of claim 31, wherein said alkali materials are selected from the group consisting of calcium oxide, sodium hydroxide, potassium hydroxide, potassium bicarbonate, sodium acetate, sodium carbonate, sodium bicarbonate, sodium benzoate, sodium acrylate, sodium methacrylate, sodium gluconate, calcium carbonate, magnesium carbonate, calcium phosphates, calcium bicarbonate, calcium gluconate, and calcium silicate.
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이 특허에 인용된 특허 (76)
Prencipe Michael (East Windsor NJ) Drago Vincent (Staten Island NY), Abrasive tooth whitening dentifrice of improved stability.
Haynie Michel B. (1259 E. 8320 South Sandy UT 84094), Dental bleach system having separately compartmented fumed silica and hydrogen peroxide and method of using.
Prencipe Michael (West Windsor NJ) Masters James G. (Flemington NJ) Drago Vincent O. (Sayreville NJ), Dentifrice composition containing calcium peroxide having heightened tooth whitening effect.
Prencipe Michael ; Wong Mike ; Drago Vincent O. ; Bentley Marcus ; Hassan Mahmoud ; Dixit Nagaraj S., Dual component antiplaque and tooth whitening composition.
Hsu Donald P. (Monmouth Junction NJ) Kohli Rajnish (Belle Meade NJ) Crawford Richard J. (Asbury NJ) Dixit Nagarj S. (Plainsboro NJ) Collins Michael A. (Hazlet NJ) Viscio David B. (Monmouth Junction N, Multilayer bicarbonate/peroxide dentifrice.
Rudy Jerome B. (Livingston NJ) Denholtz Melvin (Livingston NJ) Denholtz Jeffrey R. (Stanhope NJ) Bohm Peter D. (Freehold NJ), Periodontal composition and method.
Jan A. Orlowski ; David V. Butler, Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals.
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