IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0807295
(2004-03-24)
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발명자
/ 주소 |
- Henley,Julian L.
- Chang,Kuo Wei
- Potter,Joseph
- Goldberg,Dennis I.
- Porter,Christopher H.
- Porcelli,V. Lorenzo
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출원인 / 주소 |
- BioPhoretic Therapeutic Systems, LLC
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
49 인용 특허 :
162 |
초록
▼
An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medi
An electrokinetic delivery or diagnostic device for personal use and self-administration of a medicament to a treatment site is provided. The device includes a housing containing a power supply, a first active electrode and a ground tactile electrode. An applicator includes a pad for containing medicament for overlying the first electrode of the device. The medicament may be applied by the user to the pad, contained within the pad or contained in rupturable capsules within the pad, together with a hydrogel if necessary for imparting electrical conductivity whereby, upon application of the applicator to the treatment site, the medicament is electrokinetically transported into the treatment site. In another form, the applicator is self-contained, having a power supply, a first electrode overlying a pad and a ground electrode from the opposite side from the pad whereby the individual presses the pad against the treatment site to complete the electrical circuit and electrokinetically drive the medicament into the treatment site.
대표청구항
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What is claimed is: 1. A method of treatment by electrokinetic self-administration of a medicament into a treatment site for an individual, comprising: providing a device shaped in part to conform to at least a portion of an individual's finger and having a self-contained power source, first and se
What is claimed is: 1. A method of treatment by electrokinetic self-administration of a medicament into a treatment site for an individual, comprising: providing a device shaped in part to conform to at least a portion of an individual's finger and having a self-contained power source, first and second electrodes, and a substrate in electrical contact with said first electrode and having an exposed contact surface; providing at least one of an electrokinetically transportable medicament or a medicament with an electrically conductive carrier therefor; releasably retaining the device on the individual's finger, with the second electrode in electrical contact with the individual's finger; providing said at least one medicament in contact with said substrate or the treatment site; while the device remains retained on the individual's finger, placing the contact surface of said substrate into contact with the individual's treatment site and causing electrical current to flow through said first electrode, the electrically transportable medicament or the conductive carrier, the treatment site, the individual's body, said second electrode and said power source to electrokinetically drive the medicament into the treatment site. 2. A delivery device for self-administration of a substance to a treatment site on an individual, comprising: a self-contained disposable applicator including a pad for applying the substance, to the treatment site, a power supply, a first electrode overlying said pad and electrically connected to said power supply and a second electrode having a tactile surface in electrical contact with said power supply and lying on a side of said applicator remote from said pad, said second electrode having an electrically conductive material overlying the tactile surface, whereby, upon the individual's hand or a portion thereof in contact with said tactile surface of said second electrode holding the applicator pad against the treatment site, an electrical circuit is completed between the first electrode through the treatment site and the second electrode via the tactile surface, the electrically conductive material and the individual's hand and body for electrokinetically driving the substance into the treatment site. 3. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein delivery of the at least one medicament to the treatment site at least aids in treatment or prevention of diseases or other abnormal or cosmetic conditions of skin or mucocutaneous membrane. 4. The device according to claim 2 in combination with the substance said substance including at least one medicament, and wherein delivery of the at least one medicament to the treatment site at least aids in treatment or prevention of infection. 5. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat or prevent bacterial infection of skin. 6. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat or prevent viral infection of skin. 7. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat or prevent microbial infection of skin. 8. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to stimulate hair growth. 9. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat a wound. 10. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat acne. 11. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat psoriasis. 12. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat eczema or contact or atopic dermatitis. 13. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat pruritis, dry skin, or keratosis. 14. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat actinic keratoses. 15. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat spider veins. 16. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein delivery of the at least one medicament is at least intended to treat skin cancer. 17. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein delivery of the at least one medicament to the treatment site at least relieves pain. 18. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat a herpetic symptom. 19. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat post-herpetic neuralgia. 20. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is an antiviral. 21. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is an anesthetic. 22. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat an inflammatory condition. 23. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is dexamethasone. 24. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one anesthetic selected from the group consisting of lidocaine, xylocaine, prontocaine, prilocaine, fetanyl, remifentanil, sufentanil, alfentanil, novocaine, procaine, morphine HCI and EMLA. 25. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises an anti-proliferative agent or an anti-angiogenic agent. 26. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical selected from the group consisting of 5-fluorouracil, cisplatin, Efudex, soviudine and thalidomide. 27. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat a varicella zoster symptom. 28. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises acyclovir. 29. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises a chemical selected from the group consisting of analogs and derivatives of acyclovir. 30. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least penciclovir or famciclovir. 31. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises a behenyl alcohol. 32. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises n-docosanol. 33. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical selected from the group consisting of analogs and derivatives of n-docosanol. 34. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises 5-iodo-2 deoxyuridine (IUDR). 35. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical selected from the group consisting of cytosine arabinoside (Ara-C), adenine arabinoside (Ara-A), adenine arabinoside monophosphate (Ara-AMP), arabinofuranosyl hypoxanthine (Ara-Hx), phosphonoacetic acid (PAA), thymine arabinoside (Ara-T), 5'-amino-2',5'-dideoxy-5-iodouridine (AIU), 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U), 1-beta-D-arabinofuranosyl-E-5(2-chlorovinyl)uracil (CV-ara-U), halogenated deoxytidines BrCdR and ICdR, and bromovinyldeoxyuridine (BVDU). 36. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises an antiviral and an anesthetic. 37. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament is at least intended to treat an infection by a human papilloma virus. 38. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical selected from the group consisting of Imiquimod, sodium salicylate, tretinion, benzoyl peroxide, bleomycin, interferons, Podocon-25, Wart Off and Compound W. 39. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises an antibiotic. 40. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical selected from the group consisting of finasteride, minoxidil antidihydrotestosterones and antidihydroestrogens. 41. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least a steroidal or non-steroidal anti-inflammatory drug (NSAID). 42. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical or biologic selected from the group consisting of benzamycin, benzoyl peroxide, cleocin, T-Stat, Clearasil, Benzac, Accutane, tazarotene, adapalene, azelaic acid and erythromycin. 43. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical or biologic selected from the group consisting of anesthetics, analgesics, and other desensitizing agents. 44. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical or biologic selected from the group consisting of vasodilators, antihistamines, antimetabolites, immunosuppressives, and antineoplastic agents. 45. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said at least one medicament comprises at least one chemical or biologic selected from the group consisting of antiandrogens, beta blockers, beta-adrenergic antagonists, catecholamines, modulators of collagen deposition, and sympathomimetics. 46. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein said first electrode includes a multi-channel electrode, each electrode channel being electrically driven in a current isolated fashion through a corresponding plurality of individual current loops with each channel receiving substantially the same current level. 47. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and including a current driver, said first electrode including a plurality of current distributive channels and a plurality of current limiters coupled between said driver and said channels to provide substantially the same current level in each said channel. 48. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and wherein the device is disposable after one-time usage. 49. The device according to claim 2 in combination with the substance, said substance including at least one medicament, and including a vibratory element carried by said device and electrically coupled to said power source for inducing ultrasonic vibration into the treatment site. 50. The device according to claim 2 in combination with the substance, said substance being contained within said pad. 51. The device according to claim 2 in combination with the substance, said substance being applied to said pad on a side thereof opposite said first electrode. 52. The device according to claim 2 wherein said second electrode overlies said first electrode on a side of the applicator remote from said pad. 53. The device according to claim 2 in combination with the substance, said substance comprising an anti-fungal. 54. The device according to claim 2 in combination with the substance, said substance at least aiding in the treatment or prevention of a disease condition caused by suspected to be caused by a fungus.
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