초록 ▼

An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular port

An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular portion terminating in a free distal end. The distal end of the catheter bears a rounded tip, a portion of which is slidably disposed within the lumen of the tubular portion. The tip is porous for discharging an agent or drug to a selected site. The tip has a microporosity of less than or equal to 0.22 microns. The tubular portion is composed from a material that will expand from its nominal size when exposed to a stimulus such as heat or a solvent and return to its nominal size when the stimulus is withdrawn. By expanding the tubular portion, a physician can select the amount of the tip that is exposed to the organism, thereby customizing the catheter to the structural size of the selected site within the body.

대표청구항 ▼

What is claimed is: 1. A method of manufacturing a catheter comprising the steps of: a) forming a first tubular portion of a relatively impermeable material, the first tubular portion formed having a lumen; b) forming a second tubular portion of a porous material; c) partially disposing the secon

What is claimed is: 1. A method of manufacturing a catheter comprising the steps of: a) forming a first tubular portion of a relatively impermeable material, the first tubular portion formed having a lumen; b) forming a second tubular portion of a porous material; c) partially disposing the second tubular portion within the lumen so that a portion of the first tubular portion overlaps the second tubular portion; d) adjusting the length of the second tubular portion to conform to the dimensions of a selected site in an organism, comprising the steps of: i) heating the first tubular portion until the diameter of the lumen increases in diameter a sufficient amount to enable relative sliding movement between the first tubular portion and the second tubular portion; ii) sliding the second tubular portion in the lumen relative to the first tubular portion to provide a preselected length of the second tubular portion that extends distally beyond the distal end of the first tubular portion; and iii) cooling the first tubular portion until the first tubular portion and the second tubular portion are no longer capable of relative sliding movement; and e) establishing a near zero tolerance fit between the second tubular portion and the portion of the first tubular portion that overlaps the second tubular portion.