[특허]Method and apparatus for handling small volume fluid samples

Method and apparatus for handling small volume fluid samples 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B67D-005/42 B67D-005/40
출원번호	US-0641523 (2003-08-15)
발명자 / 주소	Massaro,Peter Geldhof,Benjamin F.
출원인 / 주소	Protedyne Corporation
대리인 / 주소	Wolf, Greenfield &
인용정보	피인용 횟수 : 0 인용 특허 : 119

초록 ▼

A small-volume sample handling system includes a chamber with first and second portions. A conduit having a flow control valve may be fluidly coupled to the first portion. A pressure in the second portion may be adjusted so that liquid samples can be aspirated and dispensed in a needle coupled to th

대표청구항 ▼

What is claimed is: 1. A system for handling fluid samples comprising: a fluid reservoir having a diaphragm separating a liquid portion of the reservoir from a gas portion of the reservoir; a variable pressure supply that includes a servo-controlled regulator to provide a controlled gas pressure in the gas portion of the reservoir; a solenoid valve having an input and an output, the solenoid valve adapted to open and close a passage between the input and the output; a conduit fluidly coupling the liquid portion of the reservoir to the input of the solenoid valve; and a sample handling channel in fluid communication with the output of the solenoid valve; wherein a pressure in the gas portion of the reservoir controls the sample handling channel to aspirate and dispense a fluid sample in response to opening of the passage in the solenoid valve. 2. The system of claim 1, wherein the variable pressure supply includes a vacuum source that provides a gas pressure below an ambient pressure and a gas supply that provides a gas pressure above an ambient pressure. 3. The system of claim 1, further comprising: a controller that controls operation of the solenoid valve to open and close the passage and controls the gas pressure in the gas portion of the reservoir. 4. The system of claim 3, wherein the solenoid valve is controlled to open and close at a high frequency. 5. The system of claim 1, wherein the sample handling channel and the solenoid valve are constructed and arranged to aspirate and dispense nanoliter-sized liquid samples. 6. The system of claim 1, wherein the sample handling channel includes a jeweled needle. 7. The system of claim 1, further comprising: a plurality of sample handling channels each associated with a corresponding solenoid valve in fluid communication with the liquid portion of the reservoir, the sample handling channels arranged in a pattern to cooperate with wells in a microtiter tray. 8. The system of claim 7, further comprising: a robotic device that moves the sample handling channels relative to a work surface so liquid samples are aspirated and dispensed in desired locations. 9. The system of claim 1, wherein the diaphragm includes a sheet of elastomeric material. 10. A liquid sample handling apparatus comprising: a fluid supply; a variable pressure supply constructed and arranged to provide a negative pressure and a positive pressure relative to an ambient pressure; a chamber having a flexible diaphragm separating first and second portions in the chamber, the first portion being in fluid communication with the fluid supply and the second portion being in communication with the variable pressure supply; a valve in fluid communication with the first portion of the chamber; and a needle in fluid communication with the valve; wherein the variable pressure supply includes a servo-controlled regulator that controls a gas pressure in the second portion of the chamber, and wherein a negative pressure in the second portion causes the needle to aspirate a fluid sample when the valve is open, and a positive pressure in the second portion causes the needle to dispense a fluid sample when the valve is open. 11. The apparatus of claim 10, wherein the variable pressure supply includes a vacuum source that provides a gas pressure below an ambient pressure and a gas supply that provides a gas pressure above an ambient pressure. 12. The apparatus of claim 10, further comprising: a controller that controls the operation of the valve to open and close and controls the pressure in the second portion of the chamber. 13. The apparatus of claim 10, wherein the valve is a solenoid valve. 14. The apparatus of claim 10, wherein the needle and the valve are constructed and arranged to aspirate and dispense nanoliter-sized liquid samples. 15. The apparatus of claim 10, further comprising: a plurality of needles each associated with a corresponding valve in fluid communication with the first portion of the chamber, the needles arranged in a pattern to cooperate with wells in a microtiter tray. 16. The apparatus of claim 15, further comprising: a robotic device that moves the needles relative to a work surface so liquid samples are aspirated and dispensed in desired locations. 17. The apparatus of claim 10, wherein the flexible diaphragm includes a sheet of elastomeric material. 18. A method of handling liquid samples using a robotically-manipulated tool, the method comprising: fluidly coupling a sample handling channel with a first end of a conduit having a valve controllable to open and close a fluid flow passage along the conduit; fluidly coupling a second end of the conduit opposite the first end to a liquid portion of a reservoir, the liquid portion of the reservoir being separated from a gas portion of the reservoir; adjusting a pressure in the gas portion of the reservoir so liquid in the liquid portion of the reservoir is urged to flow into the conduit and opening the valve so that a fluid sample is dispensed from the sample handling channel; and adjusting a pressure in the gas portion of the reservoir so liquid in the conduit is urged to flow into the liquid portion of the reservoir and opening the valve so that a fluid sample is aspirated by the sample handling channel; wherein the steps of adjusting a pressure include using a servo-controlled regulator to control pressure in the gas portion of the reservoir. 19. A method of handling liquid samples using a robotically-manipulated tool, the method comprising: raising a gas pressure in a reservoir using a servo-controlled regulator so that fluid contained in the reservoir is urged to move out of the reservoir and into a conduit connected to the reservoir; opening a valve that controls flow through the conduit; dispensing a fluid sample from a sample handling channel fluidly coupled to the conduit; lowering a gas pressure in the reservoir using a servo-controlled regulator so that fluid contained in the conduit connected to the reservoir is urged to move into the reservoir; opening a valve that controls flow through the conduit; and aspirating a fluid sample into the sample handling channel. 20. An apparatus for handling liquid samples using a robotically-manipulated tool, the apparatus comprising: means for fluidly coupling a sample handling channel with a first end of a conduit having a valve controllable to open and close a fluid flow passage along the conduit; means for fluidly coupling a second end of the conduit opposite the first end to a liquid portion of a reservoir, the liquid portion of the reservoir being separated from a gas portion of the reservoir; means for adjusting a pressure in the gas portion of the reservoir so liquid in the liquid portion of the reservoir is urged to flow into the conduit and opening the valve so that a fluid sample is dispensed from the sample handling channel; and means for adjusting a pressure in the gas portion of the reservoir so liquid in the conduit is urged to flow into the liquid portion of the reservoir and opening the valve so that a fluid sample is aspirated by the sample handling channel; wherein the means for adjusting includes a servo-controlled regulator to control pressure in the gas portion of the reservoir. 21. A system for handling fluid samples comprising: a fluid reservoir having a diaphragm separating a liquid portion of the reservoir from a gas portion of the reservoir; a solenoid valve having an input and an output, the solenoid valve adapted to open and close a passage between the input and the output; a conduit fluidly coupling the liquid portion of the reservoir to the input of the solenoid valve; and a sample handling channel having a jeweled needle in fluid communication with the output of the solenoid valve; wherein a pressure in the gas portion of the reservoir controls the sample handling channel to aspirate and dispense a fluid sample in response to opening of the passage in the solenoid valve.

이 특허에 인용된 특허 (119)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Method and apparatus for handling small volume fluid samples 원문보기

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Method and apparatus for handling small volume fluid samples 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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