초록

A formulation, for example an oil-in-water emulsion, comprising an amphoteric surfactant, alkoxylated cetyl alcohol and a polar drug. The drug may be sodium cromoglycate or nedocromil sodium. The formulation may be useful in the treatment of skin disease such as atopic dermatitis.

대표청구항 ▼

The invention claimed is: 1. A method for treating a skin condition selected from a group consisting of atopic dermatitis and eczema of a human patient, comprising: (a) providing an aqueous and oil phase composition comprising about 1-5% w/v of an amphoteric surfactant, about 0.5-4% w/v of an alkox

The invention claimed is: 1. A method for treating a skin condition selected from a group consisting of atopic dermatitis and eczema of a human patient, comprising: (a) providing an aqueous and oil phase composition comprising about 1-5% w/v of an amphoteric surfactant, about 0.5-4% w/v of an alkoxylated cetyl alcohol, and about 1-10% w/v of a polar drug selected from the group consisting of sodium cromoglycate and nedocromil sodium; and (b) applying said composition to the patient's skin. 2. A method as in claim 1 wherein said alkoxylated cetyl alcohol is selected from the group consisting of polypropoxylated cetyl alcohol and ethoxylated cetyl alcohol. 3. A method according to claim 1 wherein the amphoteric surfactant is a balanced amphoteric surfactant. 4. A method according to claim 1 wherein the amphoteric surfactant comprises disodium cocoamphodiacetate. 5. A method according to claim 1 wherein the composition further comprises a corticosteroid. 6. A method according to claim 1 wherein the composition is an oil-in-water emulsion. 7. A method according to claim 1 wherein the composition is a foam. 8. A composition consisting essentially of: sorbitan tristearate or non-ionic emulsifying wax 0.5 to 5% w/v glycerol monostearate 0.5 to 5% w/v light liquid paraffin 1 to 20% w/v white soft paraffin 1 to 10% w/v iso propyl myristate 0.5 to 5% w/v polar drug 0.1 to 20% w/v disodium edetate 0.01 to 1% w/v amphoteric surfactant 0.1 to 10% w/v alkoxylated cetyl alcohol 0.1 to 10% w/v triclosan 0.01 to 1% w/v benzyl alcohol 0.01 to 1% w/v purified water to 100% of the emulsion. 9. A method as in claim 1 wherein said composition is packaged in a tube, tub, bottle or pressurised aerosol container.