An apparatus and method acquires and stores multiple resolution images from a specimen on a support and provides to the user a low magnification, reconstructed macro image of the entire specimen, or a large portion thereof, to aid the person in selecting points of interest to be viewed or analyzed a
An apparatus and method acquires and stores multiple resolution images from a specimen on a support and provides to the user a low magnification, reconstructed macro image of the entire specimen, or a large portion thereof, to aid the person in selecting points of interest to be viewed or analyzed at higher magnifications and resolution. The reconstructed image is formed of a large number of tiled, stored images which are coordinated and assembled to form the macro image of the specimen which is displayed on a monitor. Preferably, the stored, reconstructed image is reduced further in size by a software system before it is displayed to the user. The display may be on a local monitor over a local area network or sent over the Internet to the user who is typically a pathologist. The user selects by a marker such as a cursor the defined area of interest or region and then views higher magnification images or has them analyzed. Preferably, the pathologist can scroll to shift digitized, adjacent image tiles into view on the monitor. A fully computer-controlled microscope is used to acquire and store the digitized images and the illustrated microscope can be remotely controlled to change objective lenses, focus, light intensity, filters, field diaphragm, and to shift the microscope stage by a controller.
대표청구항▼
What is claimed is: 1. A method using a computer-controlled microscope imaging system for acquiring and viewing magnified images of a specimen, comprising: capturing and digitizing image data from a plurality of adjacent, magnified, tiled images of a specimen and providing information to assemble a
What is claimed is: 1. A method using a computer-controlled microscope imaging system for acquiring and viewing magnified images of a specimen, comprising: capturing and digitizing image data from a plurality of adjacent, magnified, tiled images of a specimen and providing information to assemble and coordinate these adjacent tiled magnified images useable in formation of an overall, magnified image of a specimen at a first magnification using the computer controlled microscope; displaying a magnified overall image of the assembled and coordinated tiled images of all or a substantial portion of the specimen to a viewer; using a selector to select a point of the displayed magnified overall image for view at a higher magnification; capturing and digitizing image data for a magnified image of the selected point at a second magnification higher than the first magnification; storing the digitized image data for the overall magnified image of the specimen and for the higher magnification image of the selected point; and retrieving stored image data for the respective stored images and displaying the magnified, overall image of the specimen and the higher magnification image of the selected point at a later time. 2. A method in accordance with claim 1 wherein the displaying of a tiled overall image of the specimen comprises a using registered image tiles stored ona storage medium; and indicating on the displayed tiled, overall image at the first magnification the selected point so that the observer can recognize the point being enlarged in the displayed higher magnification, tiled overall image. 3. A method in accordance with claim 1 comprising: viewing the retrieved first magnified image and the second magnified image at the same time on computer monitors at different locations. 4. A method in accordance with claim 1 comprising: operating the microscope imaging system from a remote location. 5. A method in accordance with claim 1 comprising: providing a plurality of viewing devices for viewing the displayed images at the first and second magnification; and simultaneously sharing the same image on the plurality of viewing devices. 6. A method using a computer-controlled microscope imaging system for acquiring and viewing magnified images, comprising: capturing and digitizing image data from a plurality of adjacent, magnified, image tiles of a specimen and providing information to assemble and coordinate these magnified, image tiles into a magnified, overall image from a specimen at a first magnification using the computer controlled microscope; displaying a magnified overall image of all or a substantial portion of the specimen to a viewer; using a selector to select a point of the displayed magnified overall image for view at a higher magnification; capturing and digitizing image data for a magnified image of the selected point at a second magnification higher than the first magnification; displaying to the viewer the first magnified overall image and the second higher magnification image of the selected point; storing the image data for the overall image and the point magnified image for being displayed for later viewing; providing a plurality of viewing devices for viewing the displayed images at the first and second magnifications; and simultaneously sharing the same views on the plurality of viewing devices. 7. A method of using a computer controlled microscope imaging system having a movable stage movable relative to an objective for acquiring and viewing magnified images of a specimen, comprising: using the stage and microscope imaging system to capture image data from a plurality of adjacent, magnified images of a specimen and to provide information related to the X and Y stage coordinate system useable for assembling and coordinating these magnified images into a magnified overall image of the specimen at a first magnification with accurately marked locations for image points on this image at this first magnification; retrieving data from storage and displaying magnified overall image of all or a substantial portion the image at the first magnification to an observer; selecting one of the image points on the displayed image and using accurately marked location for the image point on the first overall image to acquire image data for a higher magnification image at the selected point; storing the higher magnification image data for the selected point; using the related X and Y stage coordinate information for retrieving from storage the higher magnification image; and displaying to the observer the higher magnification image of the selected image point and the magnified, overall image. 8. A method for displaying stored magnified images of a specimen obtained using an objective lens system, this method comprising: storing image data from a plurality of magnified image tiles of an entire specimen to provide a magnified, overall, image at a first magnification and for at least one point of interest for viewing at higher magnification; displaying a magnified, overall image of the entire specimen to a viewer which tiles are captured using the lens system; interactively selecting a point of interest on the displayed magnified, overall image of the entire specimen for viewing at a higher magnification; and transmitting the stored image data for the magnified, digitized, overall and selected point images at the lower and higher magnifications over the Internet and displaying the respective magnified, overall image and the higher magnified image of the selected point at a remote location. 9. A method in accordance with claim 8 comprising: storing the magnified, digitized images on a storage medium. 10. A method in accordance with claim 9 comprising: disseminating the stored images from the storage medium through a server for remote viewing of the stored images; and wherein the displaying of a tiled, overall image of the specimen comprises a using of registered image tiles stored on the storage medium. 11. A method in accordance with claim 10 comprising: doing a measurement analysis at a remote station using a display of the images sent by the server to a remote viewing station. 12. A method in accordance with claim 8 comprising: displaying a digitized image of the selected point at an intermediate magnification between the respective low and high magnifications. 13. A method in accordance with claim 8 comprising: remotely operating a computer-controled microscope imaging system over the Internet for scanning the specimen at the selected point to obtain the higher magnification image of the selected point on the specimen. 14. A method for displaying stored magnified images of a specimen, this method comprising: storing image data from a plurality of magnified image tiles to provide an overall image of substantially the entire specimen; displaying an overall magnified digital image of substantially the entire specimen at a first magnification; interactively selecting a point of interest on the displayed magnified overall image of the specimen by marking the point of interest for viewing at a higher magnification; retrieving from storage digitized data for a higher magnification image of the selected point of interest on the specimen; using the stored data for the higher magnification digitized image to display to the viewer the selected point and a marked location thereof on the lower magnification, displayed overall image; and interactively selecting another point of interest on the displayed overall image and retrieving stored data for another point of interest image and displaying the image of the another point of interest at a third magnification to the viewer.
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이 특허에 인용된 특허 (70)
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