IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0643631
(2003-08-18)
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발명자
/ 주소 |
- Tamada,Janet A.
- Tierney,Michael J.
- Williams,Stephen C.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
253 인용 특허 :
60 |
초록
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The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. T
The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
대표청구항
▼
What is claimed is: 1. A hydrogel composition for measuring glucose flux, said hydrogel composition comprising: a hydrophilic compound which forms a gel in the presence of water, an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and a pH of betw
What is claimed is: 1. A hydrogel composition for measuring glucose flux, said hydrogel composition comprising: a hydrophilic compound which forms a gel in the presence of water, an electrolyte, a phosphate buffer present at a concentration of between about 125 mM and about 500 mM, and a pH of between about pH 6.5 to about pH 8.5, wherein the glucose flux into the hydrogel is at least 0. 65 nmol/cm2쨌hr. 2. The hydrogel of claim 1, wherein the hydrophilic compound is selected from the group consisting of polyethylene oxide, polyvinyl alcohol, polyacrylic acid, and polyvinyl pyrrolidone, and co-polymers thereof. 3. The hydrogel composition of claim 1, wherein said hydrophilic compound comprises polyethylene oxide. 4. The hydrogel composition of claim 1, wherein said hydrophilic compound is a polymer, and said polymer is present at a weight percent of between about 0.5% to about 40%. 5. The hydrogel composition of claim 1, wherein said pH is between about pH 7 to about pH 8. 6. The hydrogel composition of claim 1, wherein the hydrogel further comprises a cross-linking agent. 7. The hydrogel composition of claim 6, wherein said cross-linking agent is present at a weight percent of from about 0.001% to about 2%. 8. The hydrogel composition of claim 7, wherein said cross-linking agent is N,N'-methylenebisacrylamide. 9. The hydrogel composition of claim 1, wherein said hydrogel is treated with Electron-beam radiation to promote cross-linking within the hydrogel. 10. The hydrogel composition of claim 1, wherein said phosphate buffer comprises monobasic and dibasic phosphate. 11. The hydrogel composition of claim 10, wherein said monobasic and dibasic phosphate comprise counter ions and said counter ions are selected from the group consisting of sodium counter ions, potassium counter ions, and mixtures thereof. 12. The hydrogel composition of claim 11, wherein for said monobasic and dibasic phosphate the counter ion is potassium. 13. The hydrogel composition of claim 1, wherein said electrolyte is a chloride salt. 14. The hydrogel composition of claim 13, wherein said chloride salt is present at a weight percent of between about 0.25% to about 2%. 15. The hydrogel composition of claim 13, wherein said chloride salt is selected from the group consisting of sodium chloride, potassium chloride, and mixtures thereof. 16. The hydrogel composition of claim 15, wherein said chloride salt is potassium chloride. 17. The hydrogel composition of claim 1, wherein said hydrogel further comprises an enzyme. 18. The hydrogel composition of claim 17, wherein said analyte is glucose and said enzyme comprises glucose oxidase. 19. The hydrogel composition of claim 1, wherein the hydrogel further comprises a biocide. 20. The hydrogel composition of claim 19, wherein said biocide is selected from the group consisting of chlorinated hydrocarbons, organometallics, metallic salts, organic sulfur compounds, phenolic compounds, quaternary ammonium compounds, surfactants, membrane-disrupting agents, and combinations thereof. 21. The hydrogel composition of claim 19, wherein said biocide is undecylenic acid or a salt thereof.
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