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Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/00
  • A61K-045/00
  • A61K-039/00
  • A61K-039/395
출원번호 US-0016047 (2004-12-18)
발명자 / 주소
  • Tobinick,Edward L.
출원인 / 주소
  • Tact IP, LLC
인용정보 피인용 횟수 : 43  인용 특허 : 14

초록

초록이 없습니다.

대표청구항

대표청구항이 없습니다.

이 특허에 인용된 특허 (14)

  1. Le Junming ; Vilcek Jan ; Daddona Peter ; Ghrayeb John ; Knight David ; Siegel Scott, Anti-TNF antibodies and peptides of human tumor necrosis factor.
  2. Collins David S. ; Bevilacqua Michael P., Composition and method for treating inflammatory diseases.
  3. Young Peter Ronald, DNA encoding interleukin-1 receptor antagonist (IL-1ra.beta.).
  4. Hannum Charles H. (Boulder CO) Eisenburg Stephen P. (Boulder CO) Thompson Robert C. (Boulder CO) Arend William P. (Denver CO) Joslin Fenneke G. (Denver CO), Interleukin-1 inhibitors.
  5. Thompson Robert C. ; Carmichael David F., Method for treating interleukin-1 mediated diseases.
  6. Roberts Eugene (Monrovia CA) Guth Lloyd (Ford\s Colony VA), Method of attenuating physical damage to the spinal cord.
  7. Roberts Eugene ; Guth Lloyd, Method of attenuation of nervous system damage.
  8. Jacobs Cindy A. (Seattle WA) Smith Craig A. (Seattle WA), Methods of lowering active TNF-a 상세보기
  • Carlino Joseph A. (San Leandro CA) Benveniste Etty N. (Birmingham AL), Methods of modulating inflammatory cytokines in the CNS using TGF-b 상세보기
  • Le Junming (Jackson Heights NY) Vilcek Jan (New York NY) Dadonna Peter (Palo Alto CA) Ghrayeb John (Thorndale PA) Knight David (Berwyn PA) Siegel Scott A. (Westborough MA), Methods of treating TNF-a 상세보기
  • Martin David ; Fischer Norman L., Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist.
  • Tobinick Edward L. ; Tobinick Arthur Jerome, Tumor necrosis factor antagonists for the treatment of neurological disorders.
  • Olmarker, Kjell; Rydevik, Bjorn, Use of certain drugs for treating nerve root injury.
  • Olmarker, Kjell; Rydevik, Bjorn, Use of certain metalloproteinase inhibitors for treating nerve disorders mediated by nucleus pulpsus.
  • 이 특허를 인용한 특허 (43)

    1. Gutman, Daniella; Levitt, Barrie; Moros, Daniel A.; Yacobi, Avraham; Rutman, Howard, Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid.
    2. Pardridge, William M.; Boado, Ruben J., Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins.
    3. Tobinick, Edward L, Cytokine antagonists for neurological and neuropsychiatric disorders.
    4. Tobinick, Edward L., Cytokine antagonists for neurological and neuropsychiatric disorders.
    5. DiPerna, Paul M, Flow regulating stopcocks and related methods.
    6. Vitalis, Timothy Z.; Gabathuler, Reinhard, Fragments of P97 and uses thereof.
    7. Vitalis, Timothy Z.; Gabathuler, Reinhard, Fragments of p97 and uses thereof.
    8. Pardridge, William M.; Boado, Ruben J., Fusion proteins for delivery of GDNF to the CNS.
    9. Pardridge, William M.; Boado, Ruben J., Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns.
    10. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    11. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    12. Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    13. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    14. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    15. Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    16. Pardridge, William M.; Boado, Ruben J., Macromolecular compositions that cross the blood-brain barrier and methods of use thereof.
    17. Moros, Daniel A., Method of treating movement disorders using barbituric acid derivatives.
    18. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing arylsulfatase A activity in the CNS.
    19. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing arylsulfatase A activity in the CNS.
    20. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing arylsulfatase A activity in the CNS.
    21. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS.
    22. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS.
    23. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing α-L-iduronidase activity in the CNS.
    24. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing α-L-iduronidase activity in the CNS.
    25. Pardridge, William M.; Boado, Ruben J., Methods and compositions for increasing α-L-iduronidase activity in the CNS.
    26. Pardridge, William M.; Boado, Ruben J., Methods for diagnosing CNS disorders with fusion antibodies that cross the blood-brain barrier in both directions.
    27. Tobinick, Edward L., Methods of inhibiting the action of TNF for neurological conditions by administering etanercept intrathecally.
    28. Tobinick, Edward Lewis, Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers.
    29. Moros, Daniel A.; Levitt, Barrie; Yacobi, Avraham, Non-sedating barbiturate compounds as neuroprotective agents.
    30. Jefferies, Wilfred; Tian, Mei Mei; Vitalis, Timothy, P97 fragments with transfer activity.
    31. Jefferies, Wilfred; Tian, Mei Mei; Vitalis, Timothy, P97 fragments with transfer activity.
    32. Jefferies, Wilfred; Vitalis, Timothy Z.; Gabathuler, Reinhard, P97-antibody conjugates and methods of use.
    33. Vitalis, Timothy Z.; Gabathuler, Reinhard, P97-antibody conjugates and methods of use.
    34. Jefferies, Wilfred; Gabathuler, Reinhard, P97-polynucleotide conjugates.
    35. DiPerna, Paul M., Slideable flow metering devices and related methods.
    36. Olmarker, Kjell; Rydevik, Bjorn, Soluble cytokine receptors TNF-α blocking antibodies for treating spinal disorders mediated by nucleus pulposus.
    37. Brown, David, Solute concentration measurement device and related methods.
    38. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
    39. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
    40. Olmarker, Kjell; Rydevik, Bjorn, Thalidomide and thalidomide derivatives for treating spinal disorders mediated by nucleus pulposus.
    41. DiPerna, Paul M., Two chamber pumps and related methods.
    42. Olmarker, Kjell; Rydevik, Bjorn, Use of TNF-alpha inhibitors for treating a nerve disorder mediated by nucleus pulposus.
    43. Olmarker, Kjell; Rydevik, Bjorn, Use of an antibody that blocks TNF-alpha activity for treating a nerve disorder mediated by nucleus pulposus.

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