The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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We claim: 1. A compound of formula (2) or a pharmaceutically acceptable salt thereof, wherein Cy2 is aryl or heteroaryl, each of which is optionally substituted and wherein each of aryl and heteroaryl is optionally fused to one or more aryl or heteroaryl rings, or to one or more saturated or par
We claim: 1. A compound of formula (2) or a pharmaceutically acceptable salt thereof, wherein Cy2 is aryl or heteroaryl, each of which is optionally substituted and wherein each of aryl and heteroaryl is optionally fused to one or more aryl or heteroaryl rings, or to one or more saturated or partially unsaturated cycloalkyl or heterocyclic rings, each of which rings is optionally substituted; X is selected from the group consisting of: a covalent bond, C0-C4-hydrocarbyl, C0-C4-hydrocarbyl-(CO)--C0-C4-hydrocarbyl, C0-C4-hydrocarbyl-(NR7)--C0-C4 -hydrocarbyl, C0-C4-hydrocarbyl-(S)--C0-C4-hydrocarbyl, C0-C4-hydrocarbyl-(O)--C0-C4-hydrocarbyl, C0-C4-hydrocarbyl-(SO)--C0-C4-hydrocarbyl, C0-C4-hydrocarbyl-(SO2)--C0-C4 -hydrocarbyl, C0-C4-hydrocarbyl-(NH)--(CO)--C0-C4-hydrocarbyl, C0-C4-hydrocarbyl-(CO)--(NH)--C0-C4-hydrocarbyl,--NH--CO--NH--,--NH--CS--NH--,--O--CO--O--,--O--CS--O--,--NH--C(NH)--NH--,--S(O)2--N(R7)--,--N(R7)--S(O)2--,--NH--C(O)--O--, and--O--C(O)--NH--, wherein R7 is selected from the group consisting of hydrogen, C1-C5-alkyl, aryl, aralkyl, acyl, heterocyclyl, heteroaryl, SO2-alkyl, SO2-aryl, CO-alkyl, CO-aryl, CO--NH-alkyl, CO--NH-aryl, CO--O-alkyl and CO--O-aryl, each of which is optionally substituted, n is 0 to 4, Y is N or CH, and T is NH2 or OH. 2. A compound according to claim 1 having S stereochemistry at C-3 position of the ring 3. A compound according to claim 1 having R stereochemistry at C-3 position of the ring 4. A compound according to claim 1, selected from the group consisting of: N-(2-Amino-phenyl)-4-[3-(pyridin-3-ylamino)-pyrrolidin-1-yl]-benzamide; (S)-N-(2-Aminophenyl)-4-(3-(pyridin-3-ylamino)pyrrolidin-1-yl) benzamide; (R)-N-(2-aminophenyl)-4-(3-(pyridin-3-ylamino)pyrrolidin-1-yl) benzamide; (S)-N-(2-Aminophenyl)-4-(3-(pyridin-3-yloxy)pyrrolidin-1-yl) benzamide (R)-N-(2-Aminophenyl)-4-(3-(pyridin-3-yloxy)pyrrolidin-1-yl) benzamide; (S)-N-(1-(4-(2-Aminophenyl carbamoyl)phenyl)pyrrolidin-3-yl)nicotinamide; (S)-N-(2-Aminophenyl)-4-(3-(pyridin-2-ylthio)pyrrolidin-1-yl) benzamide; and N-(2-Aminophenyl)-4-((S)-3-((S)-pyridin-2-ylsulfinyl) pyrrolidin-1-yl)benzamide. 5. A composition comprising a mixture of enantiomers of compounds of claim 1. 6. The composition of claim 5 wherein the mixture is racemic. 7. The composition of claim 5 wherein the mixture is enantiomerically enriched. 8. A composition comprising one or more compounds according to any one of claims 1-4 and a pharmaceutically acceptable carrier.
Saunders, Jeffrey O.; Elbaum, Daniel; Novak, Perry M.; Naegele, Douglas; Bethiel, Randy S.; Ronkin, Steven M.; Badia, Michael C.; Frank, Catharine; Stamos, Dean P.; Walters, William; Pearlman, David, Inhibitors of IMPDH enzyme technical field of the invention.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Melvin, Jr., Lawrence S.; Graupe, Michael; Venkataramani, Chandrasekar; Guerrero, Juan A., Cycloalkylidene and heterocycloalkylidene inhibitor compounds.
Ajamian, Alain; Chantigny, Yves Andre; Vaisburg, Arkadii; Raeppel, Franck; Raeppel, Stephane; Deziel, Robert, Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs.
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