초록 ▼

Medical devices having at least a portion thereof coated with a lubricious polymer are disclosed. The lubricious polymer can be, for instance, a hydrogel polymer, such as a quaternary amine acrylate polymer. To bond the lubricious polymer to the surface of the medical device, the medical device is f

Medical devices having at least a portion thereof coated with a lubricious polymer are disclosed. The lubricious polymer can be, for instance, a hydrogel polymer, such as a quaternary amine acrylate polymer. To bond the lubricious polymer to the surface of the medical device, the medical device is first subjected to a solvent and a multi-functional monomer. The solvent causes the multi-functional monomer to become imbibed into the surface of the medical device. Thereafter, a polymer having lubricious properties is polymerized on the surface of the device. The multi-functional monomer reacts with the polymer coating securely affixing the polymer coating to the device.

대표청구항 ▼

What is claimed: 1. A medical device comprising: a surface configured to move in relation to an adjacent surface; and a lubricious coating applied to the surface, the lubricious coating comprising a quaternary amine acrylate hydrogel polymer that has been cross-linked to a multi-functional monomer,

What is claimed: 1. A medical device comprising: a surface configured to move in relation to an adjacent surface; and a lubricious coating applied to the surface, the lubricious coating comprising a quaternary amine acrylate hydrogel polymer that has been cross-linked to a multi-functional monomer, the multi-functional monomer having been imbibed into the surface of the medical device, the multi-functional monomer comprising an acrylate or an ammonium compound. 2. A medical device as defined in claim 1, wherein the surface of the device is made from a thermoplastic or a thermoset. 3. A medical device as defined in claim 1, wherein the surface of the device is made from polyvinyl chloride. 4. A medical device as defined in claim 1, wherein the quaternary amine acrylate hydrogel polymer is formed from a monomer having the structure: wherein n is an integer of 2 to 3; R', R" and R'" are independently selected from the group consisting of H,C1 to C16 alkyl, aryl, arylamine, alkylamine, alkaryl and aralkyl; X is selected from the group consisting of O and NH; and Y- is an acceptable anionic counterion to the N+ of the quaternary amine. 5. A medical device as defined in claim 1, wherein the medical device comprises tracheal suction device, a catheter, a guidewire, a stylet, an enteral feeding device, an introducer, or an endotracheal tube. 6. A medical device as defined in claim 1, wherein the surface of the device is made from a silicone or a urethane. 7. A medical device as defined in claim 1, wherein the quaternary amine acrylate hydrogel polymer comprises acryloyloxyalkyl-trialkyl-substituted ammonium salt, an acryloyloxyalkyl-aryl-substituted ammonium salt, an acrylamidoalkyl-trialkyl-substituted ammonium salt, or an acrylamidoalkyl-aryl-substituted ammonium salt. 8. A medical device as defined in claim 1, wherein the quaternary amine acrylate hydrogel polymer comprises acryloyloxyethyltrimethyl ammonium chloride, or acryloyloxyethyltrimethyl ammonium methyl sulfate. 9. A medical device as defined in claim 1 wherein the multi-functional monomer comprises an alkoxylated acrylate. 10. A medical device as defined in claim 1 wherein the multi-functional monomer comprises a triacrylate. 11. A medical device as defined in claim 1, wherein the multi-functional monomer comprises a tetraacrylate, a pentaacrylate, a hexaacrylate, or a diacrylate. 12. A medical device as defined in claim 1, wherein the multi-functional monomer comprises an ethoxylated trimethylolpropane triacrylate, a propoxylated glyceryl triacrylate, trimethylolpropane triacrylate, pentaerythritol triacrylate, a propoxylated glyceryl triacrylate, a propoxylated trimethylolpropane triacrylate, trimethylol propane trimethacrylate, tris (2-hydroxy ethyl) isocyanurate triacrylate, di-trimethylolpropane tetraacrylate, dipentaerythritol pentaacrylate, an ethoxylated pentaerythritol tetraacrylate, a dipentaerythritol pentaacrylate, a pentaacrylate ester, pentaerythritol tetraacrylate, or a caprolactone modified dipentaerythritol hexaacrylate. 13. A medical device as defined in claim 1, wherein the multi-functional monomer comprises N,N-Dimethylaminoethyl acrylate dimethylsulfate, N,N-Dimethylaminoethyl acrylate methylchloride, N,N-Dimethylaminoethyl methacrylate dimethylsulfate, N,N-Dimethylaminoethyl methacrylate methylchloride, Diallyldimethylammonium chloride, acryloxyethyldimethyl benzyl ammonium chloride, acryloxyethyltrimethyl ammonium chloride, methacryloxyethyldimethyl benzyl ammonium chloride, or methacryloxyethyltrimethyl ammonium chloride. 14. A medical device as defined in claim 1, wherein the multi-functional monomer comprises an ethoxylated trimethylolpropane triacrylate.