초록 ▼

Chimeric polypeptides are disclosed that comprise a first polypeptide segment having histone acetyltransferase enzymatic activity and a second polypeptide segment that is similar to a subunit of a chromatin-associated histone deacetyltransferase protein complex. Also disclosed are nucleic acids enco

Chimeric polypeptides are disclosed that comprise a first polypeptide segment having histone acetyltransferase enzymatic activity and a second polypeptide segment that is similar to a subunit of a chromatin-associated histone deacetyltransferase protein complex. Also disclosed are nucleic acids encoding such chimeric polypeptides and eukaryotic organisms expressing such chimeric polypeptides.

대표청구항 ▼

What is claimed is: 1. An isolated nucleic acid construct encoding a chimeric polypeptide comprising the amino acid sequence set forth in SEQ ID NO:19. 2. An isolated nucleic acid construct encoding a chimeric polypeptide comprising the amino acid sequence set forth in SEQ ID NO:21. 3. The is

What is claimed is: 1. An isolated nucleic acid construct encoding a chimeric polypeptide comprising the amino acid sequence set forth in SEQ ID NO:19. 2. An isolated nucleic acid construct encoding a chimeric polypeptide comprising the amino acid sequence set forth in SEQ ID NO:21. 3. The isolated nucleic acid of claim 1 or claim 2, wherein said isolated nucleic acid construct further comprises a regulatory element to facilitate expression of said encoded chimeric polypeptide. 4. The isolated nucleic acid of claim 3, wherein said regulatory element is a cell type specific or tissue-specific promoter.