Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/19
A61K-009/22
출원번호
US-0205954
(2002-07-26)
등록번호
US-7276251
(2007-10-02)
우선권정보
KR-1997/12046(1997-04-01)
발명자
/ 주소
Kim,Myung Jin
Kim,Sun Jin
Kwon,Oh Ryong
출원인 / 주소
LG Life Sciences, Ltd., Inc.
대리인 / 주소
Sughrue Mion, PLLC
인용정보
피인용 횟수 :
2인용 특허 :
7
초록
A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles ranges from 0.1 to 40 μm.
대표청구항▼
What is claimed is: 1. A sustained-release drug composition comprising solid micorparticles consisting essentially of water-soluble hyaluronic acid having a weight greater than 2,000,000 Da or an inorganic salt thereof, and a protein or peptide drug and a stabilizer, wherein the average size of the
What is claimed is: 1. A sustained-release drug composition comprising solid micorparticles consisting essentially of water-soluble hyaluronic acid having a weight greater than 2,000,000 Da or an inorganic salt thereof, and a protein or peptide drug and a stabilizer, wherein the average size of the micorparticles range from 0.1 to 40 μm and the protein or peptide drug and the stabilizer are encased in the micorparticle of hyluronic acid or an inorganic salt thereof. 2. The composition of claim 1, wherein the molecular weight of hyaluronic acid ranges from greater than 2,000,000 Da to 3,200,000 Da. 3. The composition of claim 1, wherein the average size of microparticle ranges from 1 to 10 μm. 4. The composition of claim 1, wherein the drug is selected from the group consisting of human growth hormone, bovine somatotropin, porcine somatotropin, growth hormone releasing hormone, growth hormone releasing peptide, granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor, macrophage-colony stimulating factor, erythropoietin, bone morphogenetic protein, interferon, insulin, atriopeptin-III, monoclonal antibody, TNF, macrophage activating factor, interleukin, tumor denaturing factor, insulin-like growth factor, epidermal growth factor, tissue plasminogen activator, urokinase and a mixture thereof. 5. The composition of claim 1, wherein the inorganic salt is selected from the group consisting of sodium, potassium, lithium, calcium, ammonium, magnesium, zinc, copper and cobalt salts of hyaluronic acid. 6. The composition of claim 1, wherein the stabilizer is selected from the group consisting of a polysaccharide, protein, amino acid, lipid, fatty acid, inorganic salt, surfactant and a mixture thereof. 7. An injection formulation comprising the sustained-release composition of claim 1 dispersed in an injection medium. 8. The injection formulation of claim 7 further comprising a dispersant or preservative. 9. The injection formulation of claim 7, wherein the injection medium is selected from the group consisting of a buffered aqueous solution, ethanol, propyleneglycol, polyethyleneglycol, vegetable oil, mineral oil, squalene, cod liver oil, mono-, di-and tri-glycerid and a mixture thereof. 10. The injection formulation of claim 9, wherein the vegetable oil is selected from the group consisting of corn oil, olive oil, soy bean oil, safflower oil, cottonseed oil, sesame oil, coconut oil, castor oil and mixture thereof. 11. An aerosol formulation comprising the sustained-release composition of claim 1.
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이 특허에 인용된 특허 (7)
Makoto Suzuki JP; Kenji Ishigaki JP; Minoru Okada JP; Kenji Ono JP; Shuichi Kasai JP; Katsumi Imamori JP, Drug composition with controlled drug release rate.
Callegaro Lanfranco,ITX ; Romeo Aurelio,ITX ; Benedetti Luca,ITX, Process for the preparation of microspheres containing biologically active components.
Takada Shigeyuki (Salt Lake City UT) Uda Yoshiaki (Takarazuka JPX) Ogawa Yasuaki (Ohyamazaki-cho JPX), Prolonged release microparticle preparation and production of the same.
Houchin, Mary L.; Lee, Robin H.; Qi, Hong; Oehrtman, Greg; Jennings, Robert N.; Coleman, Scott H., Sustained release formulations using non-aqueous carriers.
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