[특허]Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis

Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07K-016/28 C07K-016/18 A61K-039/40 A61K-039/395 C07H-021/04 C07H-021/00
출원번호	US-0724274 (2003-11-26)
등록번호	US-7276589 (2007-10-02)
발명자 / 주소	Ramakrishnan,Vanitha Powers,David Johnson,Dale E. Jeffry,Ursula Bhaskar,Vinay
출원인 / 주소	PDL Biopharma, Inc.
대리인 / 주소	Howrey LLP
인용정보	피인용 횟수 : 13 인용 특허 : 17

초록 ▼

The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies

대표청구항 ▼

What is claimed is: 1. A chimeric anti-α5β1 integrin antibody comprising: a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO: 1; a light chain variable region consisting of the amino acid sequence of SEQ ID NO: 7; and a constant region, wherein the source of the constant region is a human IgG. 2. The antibody of claim 1, where the source of the constant region is human IgG4. 3. A pharmaceutical composition comprising the antibody of claim 1, and a physiologically acceptable carrier. 4. A chimeric anti-α5β1 integrin antibody comprising: a heavy chain consisting of the amino acid sequence of SEQ ID NO: 25; and a light chain consisting of the amino acid sequence of SEQ ID NO: 26. 5. A pharmaceutical composition comprising the antibody of claim 4, and a physiologically acceptable carrier. 6. A chimeric anti-α5β1 integrin antibody comprising: a heavy chain consisting of the amino acid sequence of SEQ ID NO: 28; and a light chain consisting of the amino acid sequence of SEQ ID NO: 26. 7. A pharmaceutical composition comprising the antibody of claim 6, and a physiologically acceptable carrier. 8. A humanized anti-α5β1 integrin antibody comprising: a heavy chain consisting of the amino acid sequence SEQ ID NO: 31; and a light chain consisting of the amino acid sequence of SEQ ID NO: 32. 9. A pharmaceutical composition comprising the antibody of claim 8, and a physiologically acceptable carder.

이 특허에 인용된 특허 (17)

Parish Christopher Richard (Campbell AUX), Angiogenesis inhibitory antibodies.
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Waldmann Herman (University of Cambridge ; Department of Pathology ; Immunology Div. ; Tennis Court Road Cambridge ; CB2 1QP GB3) Walsh Louise (The University of Cambridge ; Department of Pathology ;, CDR grafted humanised chimeric T-cell antibodies.
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Dalie Barbara ; Le Hung V. ; Miller Kenneth ; Murgolo Nicholas J. ; Nguyen Hanh ; Tindall Stephen ; Zavodny Paul J., Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4.
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Bendig Mary M. (London GBX) Kettleborough Catherine A. (Herts GBX) Saldanha Jose (Middlesex GBX), Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies.
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Dalie Barbara ; Miller Kenneth ; Murgolo Nicholas ; Tindall Stephen, Humanized monoclonal antibodies against human interleukin-4.
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Ruoslahti Erkki (Rancho Sante Fe CA) Koivunen Erkki (San Diego CA), Integrin-binding peptides.
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Bissell Mina J. ; Weaver Valerie M., Method for restoration of normal phenotype in cancer cells.
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Varner, Judith A., Methods for detecting and inhibiting angiogenesis.
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Pasqualini Renata ; Ruoslahti Erkki, Methods of inhibiting cancer by using superfibronectin.
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Robinson Randy R. (Los Angeles CA) Liu Alvin Y. (Oceanside CA) Horwitz Arnold H. (Los Angeles CA) Better Marc (Los Angeles CA) Wall Randolph (Sherman Oaks CA) Lei Shau-Ping (Los Angeles CA) Wilcox Ga, Modular assembly of antibody genes, antibodies prepared thereby and use.
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Robinson Randy R. (Los Angeles CA) Liu Alvin Y. (Oceanside CA) Horwitz Arnold H. (Los Angeles CA) Better Marc (Los Angeles CA) Wall Randolph (Sherman Oaks CA) Lei Shau-Ping (Los Angeles CA) Wilcox Ga, Modular assembly of antibody genes, antibodies prepared thereby and use.
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Kudo Akira (Fukuoka JPX) Nishimura Yushi (Fukuoka JPX) Ichikawa Yataro (Tokorozawa JPX) Watanabe Takeshi (Saga JPX), Mouse-human chimaeric immunoglobulin heavy chain specific for the call antigen.
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Juarez-Salinas Hector (Larkspur CA) Ott Gary S. (Livermore CA), Process for binding IgG to protein A.
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Shitara Kenya,JPX ; Hanai Nobuo,JPX ; Hasegawa Mamoru,JPX ; Miyaji Hiromasa,JPX ; Kuwana Yoshihisa,DEX, Process for producing humanized chimera antibody.
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Pedersen Jan T. (Bath GBX) Searle Stephen M. J. (Bath GBX) Rees Anthony R. (Bath GBX) Roguska Michael A. (Ashland MA) Guild Braydon C. (Concord MA), Resurfacing of rodent antibodies.
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Ladner Robert C. (Ijamsville MD) Bird Robert E. (Rockville MD) Hardman Karl (Chevy Chase MD), Single polypeptide chain binding molecules.
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Parish Christopher Richard,AUX, Therapeutic compositions and methods for inhibition and treatment of tumor associated angiogenesis.
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이 특허를 인용한 특허 (13)

Bender, Steven Lee; Casperson, Gerald Fries; Hu-Lowe, Dana Dan; Jiang, Xin; Li, Gang; North, Michael Aidan; Wang, Jianying; Wickman, Grant; Brams, Peter; Huang, Haichun; Devaux, Brigitte; Chen, Haibin; Tanamachi, Dawn M.; Toy, Kristopher; Yang, Lan; Sproul, Tim W.; Yamanaka, Mark, Alpha 5-beta 1 antibodies and their uses.
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Bender, Steven L.; Casperson, Gerald F.; Hu-Lowe, Dana D.; Jiang, Xin; Li, Gang; North, Michael A.; Wang, Jianying; Wickman, Grant; Brams, Peter; Huang, Haichun; Devaux, Brigitte; Chen, Haibin; Tanamachi, Dawn M.; Toy, Kristopher; Yang, Lan; Sproul, Tim W.; Yamanaka, Mark, Alpha5-beta1 antibodies and their uses.
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Liang, Wei-Ching; Plowman, Gregory D.; Wu, Yan; Ye, Weilan, Anti- α5 β1 antibodies and uses thereof.
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Chuntharapai, Anan; Plowman, Gregory D.; Tessier-Lavigne, Marc; Wu, Yan; Ye, Weilan, Anti-alpha5/beta1 antibody.
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Liang, Wei-Ching; Plowman, Gregory D.; Wu, Yan; Ye, Weilan, Anti-α5β1 antibodies and uses thereof.
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Liang, Wei-Ching; Plowman, Gregory D.; Wu, Yan; Ye, Weilan, Antibodies.
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Liang, Wei-Ching; Plowman, Gregory D.; Wu, Yan; Ye, Weilan, Antibodies.
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Liang, Wei-Ching; Plowman, Gregory D.; Wu, Yan; Ye, Weilan, Antibodies.
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Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
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Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis 원문보기