[특허]Method for determining an effective peclet number for a membrane adsorber device

[미국특허] Method for determining an effective peclet number for a membrane adsorber device 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-015/08 B01D-061/00
출원번호	US-0503791 (2006-08-14)
등록번호	US-7281410 (2007-10-16)
발명자 / 주소	Phillips,Michael W.
출원인 / 주소	Millipore Corporation
대리인 / 주소	Nields & Lemack
인용정보	피인용 횟수 : 1 인용 특허 : 32

초록 ▼

The method for determining an effective Peclet number for a membrane adsorber device includes the steps of (a) equilibrating the membrane adsorber device with an equilibration buffer at a known pH and conductivity; (b) challenging the membrane with a known concentration of a specific solute in said equilibration buffer; (c) monitoring the breakthrough of the solute downstream of the membrane as a function of a value selected from the group consisting of time, challenge volume and other suitable variable related to total quantity of material challenged to membrane adsorber device; (d) analyzing the solute breakthrough curve to determine pertinent flow characteristics of said membrane adsorber device by calculating the sharpness of the breakthrough curve of the membrane adsorber device and (e) comparing the results calculated in step (d) to results from known integral devices to determine the effective Peclet number.

대표청구항 ▼

What is claimed: 1. A method for determining an effective Peclet number for a membrane adsorber device comprising the steps of: (a) equilibrating the membrane adsorber device with an equilibration buffer at a known pH and conductivity; (b) challenging the membrane with a known concentration of a specific solute in said equilibration buffer; (c) monitoring the breakthrough of the solute downstream of the membrane as a function of a value selected from the group consisting of time, challenge volume and other suitable variable related to total quantity of material challenged to membrane adsorber device; (d) analyzing the solute breakthrough curve to determine pertinent flow characteristics of said membrane adsorber device by calculating the sharpness of the breakthrough curve of said membrane adsorber device; and (e) comparing the results calculated in step (d) to results from known integral devices to determine the effective Peclet number. 2. The method of claim 1 wherein step (c) is performed by a detector. 3. The method of claim 1 wherein step (d) is performed by monitoring the time of solute breakthrough. 4. The method of claim 1 wherein step (d) is performed by monitoring a variable related to the total quantity of material challenged to said membrane adsorber device at a point in time selected from the group consisting of the initial onset of solute breakthrough and a fraction of said solute breakthrough. 5. The method of claim 1 wherein step (d) is performed by monitoring a variable related to the total quantity of material challenged to said membrane adsorber device at a specific fraction of solute breakthrough. 6. The method of claim 5 wherein said fraction is from about 5% to about 50%. 7. The method of claim 5 wherein said fraction is from about 5% to about 20%. 8. The method of claim 5 wherein said fraction is from about 5% to about 10%. 9. The method of claim 1 wherein step (d) is performed by calculating a breakthrough curve sharpness and an initial onset of solute breakthrough. 10. A method for calculating an effective Peclet number for a membrane adsorber device comprising the steps of: (a) equilibrating the membrane adsorber device with an equilibration buffer at a known pH and conductivity; (b) challenging the membrane with a known concentration of a specific solute in said equilibration buffer; (c) monitoring the breakthrough of the solute downstream of the membrane as a function of a value selected from the group consisting of time, challenge volume and other suitable variable related to total quantity of material challenged to membrane adsorber device; (d) fitting the equation: description="In-line Formulae" end="lead"CA/C0=쩍*{1+erf[[(Pe )1/2*(V-Vbar)]/[2*[V*Vbar] 1/2]]}description="In-line Formulae" end="tail" where CA is the effluent solute concentration C0 is the inlet solute concentration V is the challenge volume Vbar is the challenge volume at 50% breakthrough (CA/C0=0.5) Pe is the effective Peclet number to said experimentally determined breakthrough curve to determine the effective Peclet number. 11. The method of claim 10 wherein step (d) is performed using a least-squares fit. 12. The method of claim 10 wherein step (d) is performed using a multipoint method. 13. The method of claim 12 further comprising the steps of: (e) using said equation to develop a generic plot of Pe versus (V90-V10)/V50; (f) determine V10, V50 and V90 from said experimentally determined breakthrough curve, and (g) finding Pe from said generic plot using said experimentally determined values of V10, V50 and V90 wherein V10, V50, and V90 are the breakthrough volumes corresponding to 10, 50, and 90% solute breakthrough, respectively.

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[미국특허] Method for determining an effective peclet number for a membrane adsorber device 원문보기