The invention provides compoods and methods for treating cell proliferative-diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, excipient, or diluent, and methods
The invention provides compoods and methods for treating cell proliferative-diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, excipient, or diluent, and methods of using the compounds to inhibit cellular proliferation in vitro and therapeutically.
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We claim: 1. A compound of formula: or a pharmaceutically acceptable salt thereof, wherein Y is--N(R4)--,--O--,--S--,--N(R4)SO2--,--SO2--N(R4)--,--SO2--,--N(R4)--C(O)--,--C(O)--N(R4)--,--NHC(O)NH--,--N(R4)C(O)O--,--OC(O)N(R4)--, or a covalent bond, and R1, R2, and R3 independently are--H or Ra--C
We claim: 1. A compound of formula: or a pharmaceutically acceptable salt thereof, wherein Y is--N(R4)--,--O--,--S--,--N(R4)SO2--,--SO2--N(R4)--,--SO2--,--N(R4)--C(O)--,--C(O)--N(R4)--,--NHC(O)NH--,--N(R4)C(O)O--,--OC(O)N(R4)--, or a covalent bond, and R1, R2, and R3 independently are--H or Ra--C0-C6-hydrocarbyl wherein Ra is--H or Ra is aryl or heteroaryl, each of which is optionally substituted with from 1 to 3 substituents, R4 is--H,--C(O)--Rb,--C(O)O--Rb,--C(O)NH--Rb, or Rc-C0-C6-hydrocarbyl wherein Rb is--H or--C1-C6-hydrocarbyl, and Rc is--H, or aryl or heteroaryl each of which is optionally substituted with from 1 to 3 substituents. 2. The compound according to claim 1 wherein R2 and R3 are both--H. 3. The compound according to claim 1 wherein Y is--NH--,--SO2--NH--, or--N(R4)--wherein R4 is--C(O)O--C1-C6-hydrocarbyl. 4. The compound according to claim 1 wherein R1 is aryl, benzothiazolyl, pyrimidinyl, triazolyl, benzodioxolenyl, or pyridinyl, each of which is optionally substituted with from 1 to 3 substituents. 5. The compound according to claim 4 wherein R1 is substituted with from 1-3 substituents independently selected from C1-C6-hydrocarbyl, C1-C6-hydrocarbyloxy, halo, methylthio, and acetyl. 6. The compound according to claim 1 wherein R1--Y is selected from:
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Ajamian, Alain; Chantigny, Yves Andre; Vaisburg, Arkadii; Raeppel, Franck; Raeppel, Stephane; Deziel, Robert, Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs.
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