IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0845761
(2004-05-14)
|
| 등록번호 |
US-7292893
(2007-11-06)
|
|
발명자
/ 주소 |
- Hoenig,Peter A.
- Trembly,B. Stuart
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
Lowrie, Lando & Anastasi, LLP
|
| 인용정보 |
피인용 횟수 :
4 인용 특허 :
39 |
초록
The invention provides methods for the treatment of keratinized tissue infected with a pathogen. The invention utilizes electromagnetic energy, particularly microwave energy, as a treatment means to reduce the amount of or eliminate the pathogen from the keratinized tissue.
대표청구항
▼
What is claimed is: 1. A method for treating keratinized tissue infected with a fungus comprising exposing the tissue to an effective amount of microwave energy to kill the fungus infecting the keratinized tissue. 2. The method of claim 1, wherein the microwave energy has a wave frequency from ab
What is claimed is: 1. A method for treating keratinized tissue infected with a fungus comprising exposing the tissue to an effective amount of microwave energy to kill the fungus infecting the keratinized tissue. 2. The method of claim 1, wherein the microwave energy has a wave frequency from about 10 MHz to about 30 GHz. 3. The method of claim 1, wherein the infected keratinized tissue is nail tissue. 4. The method of claim 3, wherein the nail tissue is human nail tissue. 5. The method of claim 1, wherein the keratinized tissue is the stratum corneum of epidermis tissue. 6. The method of claim 1, wherein the keratinized tissue is hair. 7. The method of claim 1, wherein the keratinized tissue is horny tissue. 8. The method of claim 1, wherein the method further includes a step to promote cooling of underlying tissue by way of reactive hyperemia. 9. The method of claim 1, wherein the method further includes a step to measure tissue temperature by way of microwave radiometry. 10. The method of claim 1, wherein the exposing step comprises exposing the keratinized tissue with an effective amount of microwave energy to heat the fungus. 11. The method of claim 1, wherein the exposing step comprises providing the microwave energy at a power to superheat the fungus. 12. The method of claim 1, wherein the exposing step comprises exposing the keratinized tissue to a plane wave of microwave energy. 13. The method of claim 1, wherein the exposing step comprises providing the microwave energy for at least about 1 minute. 14. The method of claim 1, wherein the exposing step comprises providing the electromagnetic energy at a frequency of about 10 MHz to about 10 GHz. 15. A method for treating keratinized tissue infected with a fungus comprising exposing the tissue to an effective amount of millimeter wave energy to kill the fungus infecting the keratinized tissue. 16. The method of claim 15, wherein the infected keratinized tissue is nail tissue. 17. The method of claim 16, wherein the nail tissue is human nail tissue. 18. The method of claim 15, wherein the keratinized tissue is the stratum corneum of epidermis tissue. 19. The method of claim 15, wherein the keratinized tissue is hair. 20. The method of claim 15, wherein the keratinized tissue is horny tissue. 21. The method of claim 15, wherein the method further includes a step to promote cooling of underlying tissue by way of reactive hyperemia. 22. The method of claim 15, wherein the method further includes a step to measure tissue temperature by way of microwave radiometry. 23. The method of claim 15, wherein the exposing step comprises exposing the keratinized tissue with an effective amount of millimeter energy to heat the fungus. 24. The method of claim 15, wherein the exposing step comprises providing the millimeter wave energy at a power to superheat the fungus. 25. The method of claim 15, wherein the exposing step comprises exposing the keratinized tissue to a plane wave of millimeter wave energy. 26. The method of claim 15, wherein the exposing step comprises providing the millimeter wave energy for at least about 1 minute. 27. An applicator adapted for external delivery of electromagnetic energy to a keratinized tissue infected with a pathogen comprising: a coaxial cable with only a portion of an outer conductor removed and, comprising a single aperture for delivery of the electromagnetic energy to the keratinized tissue; and an adaptor coupled to the coaxial cable that is configured to provide the electromagnetic energy from the coaxial cable to the keratinized tissue. 28. The applicator of claim 27, further comprising a waveguide. 29. The applicator of claim 27, further comprising an electromagnetic energy source coupled to the applicator. 30. The applicator of claim 29, wherein the electromagnetic energy source is selected from the group consisting of a magnetron and a solid state oscillator. 31. The applicator of claim 29, further comprising a cable coupled to the applicator and the electromagnetic energy source. 32. The applicator of claim 27, in which the adaptor is constructed and arranged to be placed externally in contact with the keratinized tissue. 33. The applicator of claim 27, in which the coaxial cable is rigid and configured for non-invasive treatment of the keratinized tissue. 34. The applicator of claim 27, in which the adaptor is flexible to allow conformance to a curved or irregular surface. 35. The applicator of claim 27, in which the adaptor is constructed and arranged to direct the electromagnetic energy to the keratinized tissue. 36. The applicator of claim 27, in which the adaptor is constructed and arranged to reduce electromagnetic energy to tissue surrounding the keratinized tissue. 37. The applicator of claim 27, in which the adaptor comprises an adhesive to permit adherence to a surface. 38. The applicator of claim 27, in which a part of the adaptor is constructed and arranged to permit trimming to an arbitrary shape. 39. An applicator adapted for external delivery of electromagnetic energy to a keratinized tissue infected with a pathogen comprising: a coaxial cable with only a portion of an outer conductor removed; and an adaptor coupled to the coaxial cable that is configured to provide the electromagnetic energy from the coaxial cable to the keratinized tissue, in which the adaptor is constructed and arranged to smooth the distribution of the electromagnetic energy provided to the keratinized tissue. 40. The applicator of claim 39, further comprising a waveguide. 41. The applicator of claim 39, further comprising an electromagnetic energy source coupled to the applicator. 42. The applicator of claim 41, wherein the electromagnetic energy source is selected from the group consisting of a magnetron and a solid state oscillator. 43. The applicator of claim 41, further comprising a cable coupled to the applicator and the electromagnetic energy source. 44. The applicator of claim 39, in which the adaptor is constructed and arranged to be placed externally in contact with the keratinized tissue. 45. The applicator of claim 39, in which the coaxial cable is rigid and configured for non-invasive treatment of the keratinized tissue. 46. The applicator of claim 39, in which the adaptor is flexible to allow conformance to a curved or irregular surface. 47. The applicator of claim 39, in which the adaptor is constructed and arranged to direct the electromagnetic energy to the keratinized tissue. 48. The applicator of claim 39, in which the adaptor is constructed and arranged to reduce electromagnetic energy to tissue surrounding the keratinized tissue. 49. The applicator of claim 39, in which the adaptor comprises an adhesive to permit adherence to a surface. 50. The applicator of claim 39, in which a part of the adaptor is constructed and arranged to permit trimming to an arbitrary shape.
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