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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0356868 (2003-02-03) |
등록번호 | US-7294143 (2007-11-13) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 38 인용 특허 : 312 |
Methods for delivering precise amounts of fluid into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid through a hollow needle. The injected fluid can be a highly conductive fluid injected in conjunction with radiofrequency ab
Methods for delivering precise amounts of fluid into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid through a hollow needle. The injected fluid can be a highly conductive fluid injected in conjunction with radiofrequency ablation to create an ablative virtual electrode. The injected conductive fluid can provide deeper and narrower conduction paths and resulting lesions. Radiofrequency ablation can be performed at the same time as the fluid injection, using the injection device as an electrode, or subsequent to the fluid injection, using a separate device. In some methods, the injected fluid is a protective fluid, injected to protect tissue adjacent to the desired lesion line. Fluid delivery can be endocardial, epicardial, and epicardial on a beating heart. The present methods find one use in performing maze procedures to treat atrial fibrillation.
The invention claimed is: 1. A method for ablation of myocardial tissue comprising: providing a hand-held instrument having a first hollow needle coupled to a first fluid delivery lumen for delivery of a first fluid and a second hollow needle coupled to a second fluid delivery lumen for delivery of
The invention claimed is: 1. A method for ablation of myocardial tissue comprising: providing a hand-held instrument having a first hollow needle coupled to a first fluid delivery lumen for delivery of a first fluid and a second hollow needle coupled to a second fluid delivery lumen for delivery of a second fluid; selecting a desired line of ablation on a surface of the tissue; applying the first needle to the tissue at a first portion of the desired line of ablation such that it penetrates the tissue; applying the second needle to the tissue at a second portion spaced apart from the desired line of ablation such that it penetrates the tissue; delivering a predetermined amount of the first fluid into the penetrated tissue to facilitate ablation of the first portion of tissue along the desired lesion line; and delivering a predetermined amount of the second fluid into the penetrated tissue to protect the second portion of tissue spaced apart from the desired lesion line. 2. A method according to claim 1 wherein the first needle reciprocates to repeatedly penetrate and deliver the first fluid to the myocardial tissue along the desired line of ablation. 3. A method according to claim 2 wherein the first fluid is introduced into the first needle by means of a first fluid reservoir and the second fluid is introduced into the second needle by means of a second fluid reservoir. 4. A method according to claim 1 wherein the first fluid applied to the myocardial tissue is a cytotoxic agent applied in amount effective to ablate the myocardial tissue. 5. A method according to claim 4 wherein the cytotoxic agent draws a lesion on the myocardium by the repeated introduction of the first needle and injection of cytotoxic fluid while moving the device along the desired lesion pattern. 6. A method according to claim 1 wherein delivery of the first or second fluid is actively injected into the tissue according to the first or second needle position in the myocardial tissue. 7. A method according to claim 1 wherein the first or second fluid is delivered to the myocardium in a predetermined, metered amount. 8. A method according to claim 1 wherein the first needle is withdrawn from the myocardial tissue and advanced to a second location along the desired line of ablation where the first needle is inserted into the myocardium and another amount of the first fluid is dispensed into the myocardial tissue. 9. A method according to claim 1 also comprising the step of applying radiofrequency ablation through the needle. 10. A method according to claim 9 wherein the needle delivers a conductive liquid. 11. A method according to claim 10 wherein the conductive liquid is a saline solution that creates an ablative virtual electrode when delivered in combination with the application of radiofrequency ablation. 12. A method according to claim 9 wherein the needle is moved along the desired lesion line on the tissue as the needle is advanced into and retracted from the tissue. 13. A method according to claim 12 wherein the liquid and the ablative radiofrequency energy are synchronized to form a virtual electrode and ablate the tissue along the desired lesion line. 14. A method according to claim 1 also comprising completing delivery of fluid along the desired lesion line and subsequently applying to the desired lesion line radiofrequency ablation. 15. A method according to claim 14 wherein the fluid is a hypertonic saline solution. 16. A method according to claim 1 wherein the fluid is a protective fluid which increases the electrical impedance of the myocardial tissue. 17. A method according to claim 16 wherein the protective fluid is delivered to tissue near a heart valve. 18. A method according to claim 16 wherein the protective fluid is delivered to tissue near a blood vessel. 19. A method according to claim 16 wherein the fluid is a hypotonic fluid. 20. A method according to claim 1 wherein the fluid comprises an ink or dye. 21. A method according to claim 1 wherein the fluid comprises a cytotoxic fluid. 22. A method according to claim 1 wherein the fluid comprises a conductive fluid. 23. A method according to claim 1 wherein the fluid comprises a hypotonic fluid. 24. A method according to claim 20 also comprising visually inspecting the ink or dye on the lesion line. 25. A method according to claim 20 wherein the ink or dye changes color at a predetermined temperature. 26. A method according to claim 1, wherein the fluid comprises a viscosity enhancing agent. 27. A method according to claim 1, wherein the delivering is performed epicardially. 28. A method according to claim 1, wherein the delivering is performed endocardially. 29. A method according to claim 1, wherein the provided hand-held instrument further comprises a needle array comprising a plurality of hollow needles in addition to the hollow needle, where in the applying includes applying the plurality of needles to penetrate the tissue, wherein the delivering includes delivering fluid into the penetrated tissue through the plurality of needles. 30. A method according to claim 1 wherein the second fluid comprises a thermally protective fluid. 31. A method for ablation of myocardial tissue comprising: providing a hand-held instrument having a first injection port for injecting a first fluid into myocardial tissue and a second injection port for injecting a second fluid into myocardial tissue; selecting a desired line of ablation on a surface of the tissue; applying the first injection port to the tissue at a portion of the desired line of ablation; applying the second injection port to the tissue at a second portion spaced apart from the desired line of ablation; delivering a predetermined amount of the first fluid into the myocardial tissue to facilitate ablation of the tissue along the desired lesion line; and delivering a predetermined amount of the second fluid into the myocardial tissue to protect tissue spaced apart from the desired lesion line. 32. A method according to claim 31 wherein the fluid applied to the myocardial tissue includes a cytotoxic agent applied in amount effective to ablate the myocardial tissue. 33. A method according to claim 31 wherein the first or second fluid is delivered to the myocardium in a predetermined, metered amount. 34. A method according to claim 31 wherein the injection device is advanced to a second location along the desired line of ablation and another amount of first fluid is dispensed into the myocardial tissue. 35. A method according to claim 31 also comprising the step of applying radiofrequency ablation through the injection device. 36. A method according to claim 35 wherein the injection device delivers a conductive liquid. 37. A method according to claim 36 wherein the conductive liquid is a saline solution that creates an ablative virtual electrode when delivered in combination with the application of radiofrequency ablation. 38. A method according to claim 35 wherein the injection port is moved along the desired lesion line on the tissue as the fluid is injected into the tissue. 39. A method according to claim 38 wherein the liquid and the ablative radiofrequency energy are synchronized to form a virtual electrode and ablate the tissue along the desired lesion line. 40. A method according to claim 31 also comprising completing delivery of fluid along the desired lesion line and subsequently applying to the desired lesion line radiofrequency ablation. 41. A method according to claim 40 wherein the fluid is a hypertonic saline solution. 42. A method according to claim 31 wherein the fluid is a protective fluid which increases the electrical impedance of the myocardial tissue. 43. A method according to claim 42 wherein the protective fluid is delivered to tissue near a heart valve. 44. A method according to claim 42 wherein the protective fluid is delivered to tissue near a blood vessel. 45. A method according to claim 42 wherein the fluid is a hypotonic fluid. 46. A method according to claim 31 wherein the fluid comprises an ink or dye. 47. A method according to claim 31 wherein the fluid comprises a cytotoxic fluid. 48. A method according to claim 46 wherein the fluid comprises a conductive fluid. 49. A method according to claim 46 wherein the fluid comprises a protective fluid. 50. A method according to claim 46 also comprising visually inspecting the ink or dye on the lesion line. 51. A method according to claim 31 wherein the ink or dye changes color at a predetermined temperature. 52. A method according to claim 31, wherein the fluid comprises a viscosity enhancing agent. 53. A method according to claim 31, wherein the delivering is performed epicardially. 54. A method according to claim 31, wherein the delivering is performed epicardially on a beating heart. 55. A method according to claim 31, wherein the delivering is performed endocardially. 56. A method according to claim 31 wherein the second fluid comprises a thermally protective fluid. 57. A method according to claim 31 wherein the second fluid comprises a hypotonic protective fluid.
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