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[미국특허] Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-016/30
  • C07K-016/18
출원번호 US-0405123 (2003-04-02)
등록번호 US-7294701 (2007-11-13)
발명자 / 주소
  • Reiter,Yoram
  • Haus Cohen,Maya
출원인 / 주소
  • Technion Research & Development Foundation Ltd.
인용정보 피인용 횟수 : 0  인용 특허 : 37

초록

An antibody fragment and methods of utilizing same are provided. The antibody fragment includes an antigen binding region capable of binding an extracellular portion of a P-glycoprotein thereby at least partially inhibiting drug efflux activity in multidrug resistant cells.

대표청구항

What is claimed is: 1. A single chain Fv antibody comprising an antigen binding region capable of binding an extracellular portion of a P-glycoprotein, wherein said antigen binding region is encoded by a nucleic acid sequence as set forth by SEQ ID NO:2.

이 특허에 인용된 특허 (37) 인용/피인용 타임라인 분석

  1. Zelle Robert E. (Stow MA) Harding Matthew W. (Acton MA), Amino acid derivatives with improved multi-drug resistance activity.
  2. Rubenstein Kenneth Edward (Palo Alto CA) Leute Richard K. (Sunnyvale CA), Antibody steric hindrance immunoassay with two antibodies.
  3. Frossard Philippe M. (Palo Alto CA), Apo AI/CIII genomic polymorphisms predictive of atherosclerosis.
  4. Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and.
  5. Siegall Clay B., Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica.
  6. Ladner Robert C. (Ijamsville MD) Guterman Sonia K. (Belmont MA) Roberts Bruce L. (Milford MA) Markland William (Milford MA) Ley Arthur C. (Newton MA) Kent Rachel B. (Boxborough MA), Directed evolution of novel binding proteins.
  7. Ladner Robert C. (Ijamsville MD) Guterman Sonia K. (Belmont MA) Roberts Bruce L. (Milford MA) Markland William (Milford MA) Ley Arthur C. (Newton MA) Kent Rachel B. (Boxborough MA), Directed evolution of novel binding proteins.
  8. Uzgiris Egidijus E. (Schenectady NY), Electrophoretic method of detecting antigen-antibody reaction.
  9. Piwnica-Worms David R. (Wellesley MA), Evaluation and treatment of the multidrug resistance phenotype.
  10. Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
  11. Barbas Carlos (La Jolla CA) Kang Angray (Carlsbad CA) Lerner Richard A. (La Jolla CA), Heterodimeric receptor libraries using phagemids.
  12. Wands Jack R. (Waban MA) Zurawski ; Jr. Vincent R. (West Chester PA) Schoemaker ; Hubert J. P. (Newton MA), Immunoassay utilizing monoclonal high affinity IgM antibodies.
  13. Simons Malcolm J. (Fryerstown AUX), Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes.
  14. Wigler Michael H. ; Sorge Joseph A., Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using.
  15. Kimae Yoichi,JPX ; Yoshimatsu Shunji,JPX ; Itoda Norio,JPX ; Matsuo Takashi,JPX ; Noda Naoki,JPX, Method for manufacturing acryloxypropysilane.
  16. Ling Victor (Toronto CAX) Kartner Norbert (Ajax CAX), Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone.
  17. Neuwelt Edward A. (4246 SW. McDonnell Ter. Portland OR 97201), Method for the delivery of genetic material across the blood brain barrier.
  18. Huang Grace P. (Miami FL) Rhode Peter R. (Miami FL) Stinson Jeffrey R. (Davie FL) Wong Hing C. (Ft. Lauderdale FL), Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage.
  19. Smulson Mark E. (Washington DC) Bhatia Kishor (Arbutus MD) Huppi Konrad (Reston VA), Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for hu.
  20. Johnson Kevin Stuart,GBX ; Winter Gregory Paul,GBX ; Griffiths Andrew David,GBX ; Smith Andrew John Hammond,GBX ; Waterhouse Peter Michael,AUX, Methods for producing members of specific binding pairs.
  21. McCafferty John,GBX ; Pope Anthony Richard,GBX ; Johnson Kevin Stuart,GBX ; Hoogenboom Henricus Renerus Jacobus Mattheus,GBX ; Griffiths Andrew David,GBX ; Jackson Ronald Henry,GBX ; Holliger Kaspar , Methods for producing members of specific binding pairs.
  22. Trojanowski John Q. (Philadelphia PA) Lee Virginia M-Y. (Philadelphia PA), Modified avidin-biotin technique.
  23. Cianfriglia Maurizio,ITX, Monoclonal antibodies to glycoprotein P.
  24. Eugene Metchetner ; Igor B. Roninson, Monoclonal antibody to a human MDR1 multidrug resistance gene product and uses.
  25. Mechetner Eugene (Chicago IL) Roninson Igor B. (Wilmette IL), Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses.
  26. Garrard Lisa J. ; Henner Dennis J. ; Bass Steven ; Greene Ronald ; Lowman Henry B. ; Wells James A. ; Matthews David J., Monovalent phage display.
  27. Bellet Dominique (Paris MA FRX) Wands Jack R. (Waban MA), Multiepitopic immunometric assay.
  28. Engel Jurgen (Alzenau DEX) Kutscher Bernhard (Maintal DEX) Fleischhauer Ilona (Offenbach DEX) Szelenyi Stefan (Schwalg DEX) Metzenauer Peter (Grundau DEX) Werner Ulrich (Miehlen DEX), Phthalazinone derivatives that modulate multi-drug resistance.
  29. Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Positive-negative selection methods and vectors.
  30. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
  31. Dower William J. (Menlo Park CA) Cwirla Steven E. (Palo Alto CA), Recombinant library screening methods.
  32. Dower William J. (Menlo Park CA) Cwirla Steven E. (Palo Alto CA), Recombinant library screening methods.
  33. Piasio ; Roger N. ; Ryan ; James W. ; Woiszwillo ; James E., Reverse sandwich immunoassay.
  34. Huse William D. (Del Mar CA), Surface expression libraries of heteromeric receptors.
  35. Gusella James F. (Framingham MA), Test for Huntington\s disease.
  36. Miles Laughton E. M. (Stanford CA), Universal reagent 2-site immunoradiometric assay using labelled anti (IgG).
  37. Ladner, Robert C.; Guterman, Sonia K.; Roberts, Bruce L.; Markland, William; Ley, Arthur C.; Kent, Rachel B., Viruses expressing chimeric binding proteins.

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