System of components for preparing oligonucleotides
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12P-019/34
C12P-019/00
G06F-019/00
C12Q-001/68
출원번호
US-0067638
(1998-04-28)
등록번호
US-7321828
(2008-01-22)
발명자
/ 주소
Cowsert,Lex M.
Baker,Brenda F.
McNeil,John
Freier,Susan M.
Sasmor,Henri M.
Brooks,Douglas G.
Ohashi,Cara
Wyatt,Jacqueline R.
Borchers,Alexander H.
Vickers,Timothy A.
출원인 / 주소
Isis Pharmaceuticals, Inc.
인용정보
피인용 횟수 :
147인용 특허 :
200
초록▼
Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of
Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A "virtual" oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.
대표청구항▼
What is claimed is: 1. A system of associated components for preparing a set of oligonucleotides that modulates expression of a selected nucleic acid comprising: a computer system that i) generates a list of oligonucleotide sequences according to a desired oligonucleotide length, thereby generating
What is claimed is: 1. A system of associated components for preparing a set of oligonucleotides that modulates expression of a selected nucleic acid comprising: a computer system that i) generates a list of oligonucleotide sequences according to a desired oligonucleotide length, thereby generating a series of oligonucleotide sequences; ii) applies a virtual oligonucleotide chemistry to the oligonucleotide sequences generated in step i) to yield a set of virtual oligonucleotides; iii) generates a subset of said set of virtual oligonucleotides, said subset being the result of a decision to target a functional region of said selected nucleic acid; and iv) generates synthesis instructions in computer manipulable form for said oligonucleotide sequences in said subset of said set of virtual oligonucleotides; an automated synthesizer that receives said synthesis instructions from said computer system and synthesizes only said oligonucleotide sequences in said subset of said set of virtual oligonucleotides, wherein the product of said synthesis is a set of synthesized oligonucleotides; and an apparatus that accepts said set of synthesized oligonucleotides and performs at least one procedure for each of said synthesized oligonucleotides wherein said procedure identifies particular members of said set that modulate expression of said selected nucleic acid. 2. The system of claim 1 wherein said functional region is the transcription start site, 5' cap, start codon, 5' untranslated region, 3' untranslated region, stop codon, 5' splice site or polyadenylation site. 3. A system of associated components for preparing a set of oligonucleotides that modulates expression of a selected nucleic acid comprising: a computer system that i) generates a list of oligonucleotide sequences according to a desired oligonucleotide length, thereby generating a series of oligonucleotide sequences; ii) applies a virtual oligonucleotide chemistry to the oligonucleotide sequences generated in step i) to yield a set of virtual oligonucleotides; iii) generates a subset of said set of virtual oligonucleotides, said subset being the result of a decision to: a) target a functional region of said selected nucleic acid, b) target an accessible site on said selected nucleic acid, and/or c) uniformly distribute oligonucleotide compounds across said selected nucleic acid; and iv) generates synthesis instructions in computer manipulable form for said oligonucleotide sequences in said subset of said set of virtual oligonucleotides; an automated synthesizer that receives said synthesis instructions from said computer system and synthesizes only said oligonucleotide sequences in said subset of said set of virtual oligonucleotides, wherein the product of said synthesis is a set of synthesized oligonucleotides; a first apparatus that accepts said set of synthesized oligonucleotides and performs at least one procedure for each of said synthesized oligonucleotides wherein said procedure identifies particular members of said set that modulate expression of said selected nucleic acid; and a second apparatus for analyzing said set of synthesized oligonucleotides by a method or technique, selected from the group consisting of liquid chromatography, optical densiometry, mass speetroscopy, gel fluorescence and scintillation imaging, and capillary gel electrophoresis. 4. A system of associated components for preparing a set of oligonucleotides that modulates expression of a selected nucleic acid comprising: a computer system that i) generates a list of oligonucleotide sequences according to a desired oligonucleotide length, thereby generating a series of oligonucleotide sequences; ii) applies a virtual oligonucleotide chemistry to the oligonucleotide sequences generated in step i) to yield a set of virtual oligonucleotides; iii) generates a subset of said set of virtual oligonucleotides, said subset being the result of a decision to: a) target a functional region of said selected nucleic acid, b) target an accessible site on said selected nucleic acid, and/or c) uniformly distribute oligonucleotide compounds across said selected nucleic acid; and iv) generates synthesis instructions in computer manipulable form for said oligonucleotide sequences in said subset of said set of virtual oligonucleotides; an automated synthesizer that receives said synthesis instructions from said computer system and synthesizes only said oligonucleotide sequences in said subset of said set of virtual oligonucleotides, wherein the product of said synthesis is a set of synthesized oligonucleotides; and an apparatus that accepts said set of synthesized oligonucleotides and performs at least one procedure for each of said synthesized oligonucleotides wherein said procedure identifies particular members of said set that modulate expression of said selected nucleic acid.
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이 특허에 인용된 특허 (200)
Tkachuk Zenovy (Kiev SUX) Kvasyuk Eugeny (Kiev SUX) Matsuka Gennady (Kiev SUX) Mikhailopulo Igor (Kiev SUX), (2′-5′) oligoadenylate analogues useful as inhibitors of host-v5.-graft response.
Dhanoa, Daljit S.; Doller, Dario; Meegalla, Sanath; Soll, Richard M.; Wisnewski, Nancy; Silver, Gary; Stinchcomb, Dan T.; Seward, R. Lee; Agrafiotis, Dimitris; Sha, Deyou, 1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides.
Huynh Dinh Tam (Croissy/Seine FRX) Gouyette Catherine (Vanves FRX) Igolen Jean (Le Mesnil St. Denis FRX), 2,N6-disubstituted and 2,N6-trisubstituted adenosine-3′-phosphoramidites.
Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 2′,5′-phosphorothioate oligoadenylates and their covalent conjugates with polylysine.
Albertsen Hans (Salt Lake City UT) Anand Rakesh (Cheshire UT GB2) Carlson Mary (Salt Lake City UT) Groden Joanna (Salt Lake City UT) Hedge Philip J. (Cheshire UT GB2) Joslyn Geoff (Salt Lake City UT), APC gene and nucleic acid probes derived therefrom.
Cook Philip D. (Carlsbad CA) Delecki Daniel J. (Radnor PA) Guinosso Charles (Vista CA), Acyclic nucleoside analogs and oligonucleotide sequences containing them.
Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.
Harris Paul C. (Edmonds WA) Genstler Curtis C. (Redmond WA), Automated patient sample analysis instrument having tubes and reaction wells washing apparatus.
Sanghvi Yogesh S. (Carlsbad CA) Cook Phillip D. (Carlsbad CA), Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling.
Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Vasseur Jean J. (San Marcos CA) Debart Francoise (Montpellier FRX), Backbone modified oligonucleotide analogues.
Sanghvi Yogesh S. (San Marcos CA) Cook Phillip D. (Vista CA), Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling.
Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Ramsay Shaw Barbara (Durham NC), Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same.
Altmann Karl-Heinz (Basel CHX) Imwinkelried Rene (Brig-Glis CHX) Eschenmoser Albert (Kusnacht CHX), Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use.
Altmann Karl-Heinz (Basel CHX) Imwinkelried Rene (Brig-Glis CHX) Eschenmoser Albert (Kusnacht CHX), Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use.
Bertsch-Frank Birgit (Rheinfelden DEX) Klasen Claas-Juergen (Freigericht DEX) Lieser Thomas (Hapau DEX) Mueller Klaus (Hasselroth DEX) Bewersdorf Martin (Gelnhausen DEX), Coated sodium percarbonate particles, a process for their production and detergent, cleaning and bleaching compositions.
Ohtsuka Eiko (Sappro JPX) Inoue Hideo (Sappro JPX) Morisawa Hirokazu (Kawasaki JPX) Shibahara Susumu (Kawasaki JPX) Mukai Sachiko (Kawasaki JPX) Nishihara Tohru (Kurashiki JPX), Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and st.
Hubbell Earl A. (Mt. View CA) Morris MacDonald S. (San Jose CA) Winkler James L. (Palo Alto CA), Computer-aided engineering system for design of sequence arrays and lithographic masks.
Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA) Kaiser ; Jr. Robert J. (Glendale CA), DNA-reporter conjugates linked via the 2′or 5′-primary amino group of the 5′-terminal nucleoside.
Blatter Harold ; Horlander Thomas Edward ; Bridgewater Kevin Elliott ; Deiss Michael Scott, Decoding system and data format for processing and storing encrypted broadcast, cable or satellite video data.
Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) De Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel C, Dinucleoside phosphinates and their pharmaceutical compositions.
Froehler Brian (Belmont CA) Matteucci Mark (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified purines.
Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Exonuclease resistant terminally substituted oligonucleotides.
Rogers Thomas E. (Manchester MO) Gray Steven H. (Ellisville MO) Devadas Balekudru (Chesterfield MO) Adams Steven P. (St. Charles MO), Improved probes using nucleosides containing 3-dezauracil analogs.
Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke Shee L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
Benner Steven A. (Hadlaubstrasse 151 CH-8006 Zurich CHX), Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases.
Magda Darren (Cupertino CA) Sessler Jonathan L. (Austin TX) Iverson Brent L. (Austin TX) Sansom Petra I. (Austin TX) Crofts Shaun P. (Campbell CA), Method of expanded porphyrin-oligonucleotide conjugate synthesis.
Edwards Cynthia A. (Menlo Park CA) Fry Kirk E. (Palo Alto CA) Cantor Charles R. (Boston MA) Andrews Beth M. (Maynard MA 4), Method of ordering sequence binding preferences of a DNA-binding molecule.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
Agrafiotis, Dimitris K.; Lobanov, Victor S.; Salemme, Francis R., Method, system and computer program product for non-linear mapping of multi-dimensional data.
Agrafiotis Dimitris K. ; Lobanov Victor S. ; Salemme Francis R., Method, system, and computer program product for representing similarity/dissimilarity between chemical compounds.
Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA) Eder Paul S. (Iowa City IA) Dagle John M. (Iowa City IA), Methods for blocking the expression of specifically targeted genes.
Thompson Katie A. ; Foster Lyndon M. ; Peterson Todd C. ; Nasby Nicole Marie ; Brian Paul, Methods for generating and screening novel metabolic pathways.
Matteucci Mark (Burlingame CA) Jones Robert J. (Daly City CA) Munger John (San Francisco CA), Modified internucleoside linkages having one nitrogen and two carbon atoms.
Lin Kuei-Ying (Fremont CA) Matteucci Mark (Burlingame CA), Non-nucleoside linkers for convenient attachment of labels to oligonucleotides using standard synthetic methods.
Shizuya Hiroaki (1632 Indiana Ave. South Pasadena CA 91030) Millar Sharon L. (1825 Lanai St. West Covina CA 91792), Non-radioisotope tagging of fragments.
Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
Nguyen Thanh T. (Tigy FRX) Helene Claude (Saint Cyr en Val FRX) Asseline Ulysse (La Source FRX), Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis a.
Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Nuclease resistant compounds.
Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA), Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression.
Haff Lawrence A. ; Picozza Enrico ; Bloch Will ; Ragusa Robert ; DiCesare Joseph ; Tracy David ; Saviano Paul ; Woudenberg Timothy M., Nucleic acid amplification reaction apparatus.
Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA), Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled.
Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel CHX), Nucleoside phosphinate compounds and compositions.
Klevan Leonard (Washington DC) Gebeyehu Gulilat (Silver Spring MD) Rao Prasad Y. (Damascus MD), Nucleotide analogs for nucleic acid labeling and detection.
Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa
상세보기
Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
Bischofberger Norbert (San Carlos CA) Kent Ken (Mountain View CA) Wagner Rick (Burlingame CA) Buhr Chris (Daly City CA) Lin Kuei-Ying (Fremont CA), Oligonucleotide analogs capable of passive cell membrane permeation.
Weis Alexander Ludvik (Berwyn PA) Hausheer Frederick Herman (San Antonio TX) Chaturvedula Prasad Venkata Chala (Exton PA) Delecki Daniel Joseph (Radnor PA) Cavanaugh ; Jr. Paul Francis (West Chester , Oligonucleotide analogues containing phosphate diester linkage substitutes, compositions thereof, and precursor dinucleo.
Warren ; III Harold C. (Rush NY) Oakes Fred T. (Rochester NY), Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction proce.
Haralambidis Jim (Box Hill South AUX) Tregear Geoffrey W. (Hawthorn AUX), Oligonucleotide-polyamide conjugates and methods of production and applications of the same.
Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA) Kaiser ; Jr. Robert J. (Glendale CA), Oligonucleotides possessing a primary amino group in the terminal nucleotide.
Lebleu Bernard (Montpellier FRX) Bayard Bernard (Castelnau Le Lez FRX), Oligonucleotides with modified phosphate and modified carbohydrate moieties at the respective chain termini.
Imbach Jean-Louis (Montpellier FRX) Gosselin Gilles J. M. (Montpellier FRX), Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Shaw Barbara R. (Durham NC), Oligoribonucleoside and oligodeoxyribonucleoside boranophosphates.
Meyer ; Jr. Rich B. (Woodinville WA) Gall Alexander A. (Bothell WA) Reed Michael W. (Seattle WA), Peptide linkers for improved oligonucleotide delivery.
Misiura Konrad (Lodz PLX) Gait Michael (Cambridge GB3), Phosphoramidite derivatives, their preparation and the use thereof in the incorporation of reporter groups on synthetic.
Maddry Joseph A. (Birmingham AL) Reynolds Robert C. (Birmingham AL) Secrist John A. (Birmingham AL) Montgomery John A. (Birmingham AL) Crooks Peter A. (Lexington KY), Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages.
Caruthers Marvin H. (Boulder CO) Marshall William S. (Boulder CO) Brill Wolfgang (Freiburg DEX) Nielsen John (Horsholm DKX), Polynucleotide phosphorodithioate.
Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use.
Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences.
Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Ramsay Shaw Barbara (Durham NC), Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates.
Hawkins Mary E. (Potomac MD) Pfleiderer Wolfgang (Konstanz MD DEX) Davis Michael D. (Rockville MD) Balis Frank (Bethesda MD), Pteridine nucleotide analogs as fluorescent DNA probes.
Van Ness Jeffrey (Bothell WA) Petrie Charles R. (Woodinville WA) Tabone John C. (Bothell WA) Vermeulen Nicolaas M. J. (Woodinville WA), Solid supports for nucleic acid hybridization assays.
Gordon Julian (307 E. Sheridan Rd. Lake Bluft IL 60044) Minks Michael A. (Biochemistry Dept. ; University of the Witwatersrand ; 1 Jan Smuts Ave Johannesburg 2001 ZAX), Specific antibody to the native form of 2′5′-oligonucleotides, the method of preparation and the use as reagents in im.
Cook Phillip Dan (Carlsbad CA) Manoharan Muthiah (Carlsbad CA) Ramasamy Kanda S. (Laguna Hills CA), Substituted purines and oligonucleotide cross-linking.
Dower William J. (Menlo Park CA) Barrett Ronald W. (Sunnyvale CA) Gallop Mark A. (Palo Alto CA) Needels Michael C. (Oakland CA), Synthesizing and screening molecular diversity.
Agrafiotis Dimitris K. (Exton PA) Bone Roger F. (Bridgewater NJ) Salemme Francis R. (Kennett Square PA) Soll Richard M. (Lawrenceville NJ), System and method of automatically generating chemical compounds with desired properties.
Agrafiotis Dimitris K. (Exton PA) Bone Roger F. (Bridgewater NJ) Salemme Francis R. (Kennett Square PA) Soll Richard M. (Lawrenceville NJ), System and method of automatically generating chemical compounds with desired properties.
Dimitris K. Agrafiotis ; Roger F. Bone ; Francis R. Salemme ; Richard M. Soll, System, method and computer program product for identifying chemical compounds having desired properties.
Agrafiotis Dimitris K. (Exton PA) Bone Roger F. (Bridgewater NJ) Salemme Francis R. (Kennett Square PA) Soll Richard M. (Lawrenceville NJ), System, method, and computer program for at least partially automatically generating chemical compounds having desired p.
Agrafiotis Dimitris K. ; Bone Roger F. ; Salemme Francis R. ; Soll Richard M., System, method, and computer program product for at least partially automatically generating chemical compounds with des.
Dimitris K. Agrafiotis ; Victor S. Labanov ; Francis R. Salemme, System, method, and computer program product for representing proximity data in a multi-dimensional space.
Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA), Texaphyrin metal complexes having improved functionalization.
Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA) Kral Vladimir A. (Austin TX) Magda Darren (Cupertino CA), Texaphyrin-oligonucleotide conjugates.
Peterson Michael G. (So. San Francisco CA) Baichwal Vijay R. (So. San Francisco CA) Strulovici Berta (So. San Francisco CA), Transcription factor-DNA binding assay.
Reed Michael W. (3575 NE. 180th Seattle WA 98105) Meyer ; Jr. Rich B. (15411 NE. 176th Pl. Woodinville WA 98072), Trifunctional intermediates for preparing 3′-tailed oligonucleotides.
Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages.
Dhanoa, Daljit S.; Doller, Dario; Meegalla, Sanath; Soll, Richard M.; Agrafiotis, Dimitris; Wisnewski, Nancy; Silver, Gary M.; Stinchcomb, Dan T.; Seward, R. Lee, Use of 1,3-substituted pyrazol-5-yl sulfonates as pesticides.
Hofstadler, Steven A.; Gutierrez, Jose R.; Hannis, James C.; Drader, Jared J.; Bare, Rex O.; Smith, Jeffrey C.; Gleason, Paul J.; Nathanson, Jared, Ionization probe assemblies.
Hofstadler, Steven A.; Gutierrez, Jose R.; Hannis, James C.; Drader, Jared J.; Bare, Rex O.; Smith, Jeffrey C.; Gleason, Paul J.; Nathanson, Jared, Ionization probe assemblies.
Hofstadler, Steven A.; Gutierrez, Jose R.; Hannis, James C.; Drader, Jared J.; Bare, Rex O.; Smith, Jeffrey C.; Gleason, Paul J.; Nathanson, Jared, Ionization probe assemblies.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John, Method for rapid detection and identification of bioagents.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John, Method for rapid detection and identification of bioagents.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John, Method for rapid detection and identification of bioagents.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven; McNeil, John, Method for rapid detection and identification of bioagents.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven; McNeil, John, Method for rapid detection and identification of bioagents.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Hannis, James C., Method for rapid detection and identification of bioagents in epidemiological and forensic investigations.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Sofianos, Dino J.; Rudnick, Karl H.; Knize, Duane J.; Stoughton, Roland B.; Basham, Jr., Cecil L.; Lewis, Clifford T.; Larson, Brons M.; Bar-on, Jonathan R.; Murray, Dennis P.; Robbins, David W.; Penhune, John P., Methods and apparatus for genetic evaluation.
Ecker, David J.; Sampath, Rangarajan; Blyn, Lawrence B.; Hofstadler, Steven A.; Hall, Thomas A., Methods for concurrent identification and quantification of an unknown bioagent.
Ecker, David J.; Sampath, Rangarajan; Blyn, Lawrence B.; Hofstadler, Steven A.; Hall, Thomas A., Methods for concurrent identification and quantification of an unknown bioagent.
Ecker, David J.; Sampath, Rangarajan; Blyn, Lawrence B.; Hofstadler, Steven A.; Hall, Thomas A., Methods for concurrent identification and quantification of an unknown bioagent.
Ecker, David J.; Hofstadler, Steven A.; Sampath, Rangarajan; Blyn, Lawrence B.; Hall, Thomas A.; Massire, Christian, Methods for identification of coronaviruses.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Stephen A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Hall, Thomas A.; Jiang, Yun; Hannis, James C.; White, Neill; Samant, Vivek; Eshoo, Mark W.; Drader, Jared J., Methods for identifying bioagents.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven; McNeil, John; Crooke, Stanley T.; Hannis, James C., Methods for identifying bioagents.
Hofstadler, Steven A.; Hall, Thomas A.; Ecker, David J.; Blyn, Lawrence B.; Eshoo, Mark W.; Samant, Vivek; White, Neill, Methods for rapid forensic analysis of mitochondrial DNA.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Hall, Thomas A.; Jiang, Yun; Hannis, James C.; White, Neil; Samant, Vivek; Eshoo, Mark W.; Drader, Jared J., Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Hall, Thomas A.; Jiang, Yun; Hannis, James C.; White, Neill K.; Samant, Vivek; Eshoo, Mark W.; Drader, Jared J., Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence; Hall, Thomas A.; Jiang, Yun; Hannis, James C.; White, Neill; Samant, Vivek; Eshoo, Mark W.; Drader, Jared James, Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy.
Ecker, David J.; Hofstadler, Steven A.; Hall, Thomas A.; Lowery, Kristin Sannes, Methods for rapid identification and quantitation of nucleic acid variants.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Methods for rapid identification of pathogens in humans and animals.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Ranken, Raymond; Hall, Thomas A., Methods for rapid identification of pathogens in humans and animals.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Ranken, Raymond; Hall, Thomas A., Methods for rapid identification of pathogens in humans and animals.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence B.; Ranken, Raymond; Hall, Thomas A., Methods for rapid identification of pathogens in humans and animals.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T.; Blyn, Lawrence; Ranken, Ray; Hall, Thomas A., Methods for rapid identification of pathogens in humans and animals.
Hofstadler, Steven A.; Cummins, Lendell L., Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture.
Hofstadler, Steven A.; Cummins, Lendell L., Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C.; Oberkramer, Kevin S.; Bergold, Ronald K., Microplate handling systems and related computer program products and methods.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C.; Oberkramer, Kevin S.; Bergold, Ronald K., Microplate handling systems and related computer program products and methods.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C., Mixing cartridges, mixing stations, and related kits, systems, and methods.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C., Sample processing units, systems, and related methods.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C., Sample processing units, systems, and related methods.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C., Sample processing units, systems, and related methods.
Hofstadler, Steven A.; Drader, Jared J.; Gutierrez, Jose R.; Gleason, Paul J.; Bare, Rex O.; Miller, Robert D.; Smith, Jeffrey C., Sample processing units, systems, and related methods.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby.
Ecker, David J.; Hofstadler, Steven A.; Hall, Thomas A.; Sannes-Lowery, Kristin, Systems and methods for rapid identification of nucleic acid variants.
Hofstadler, Steven A.; Gutierrez, Jose R.; Hannis, James C.; Drader, Jared J.; Bare, Rex O.; Smith, Jeffrey C.; Gleason, Paul J.; Nathanson, Jared; Bergold, Ronald K.; Miller, Robert D.; Oberkramer, Kevin S., Systems for bioagent indentification.
Ecker, David J.; Griffey, Richard H.; Sampath, Rangarajan; Hofstadler, Steven A.; McNeil, John; Crooke, Stanley T., Systems for rapid identification of pathogens in humans and animals.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of Adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an Adiponectin (ADIPOQ).
Collard, Joseph; Khorkova Sherman, Olga, Treatment of Methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an adiponectin (ADIPOQ).
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos; Shen, Gang, Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos; Shen, Gang, Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF.
Faghihi, Mohammad Ali; Coito, Carlos, Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisene transcript to CSF3.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of hepatocyte growth factor (HGF) related diseases by inhibition of natural antisense transcript to HGF.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of hepatocyte growth factor (HGF) related diseases by inhibition of natural antisense transcript to HGF.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of insulin gene (INS) related diseases by inhibition of natural antisense transcript to an insulin gene (INS).
Collard, Joseph; Khorkova Sherman, Olga, Treatment of insulin receptor substrate 2 (IRS2) related diseases by inhibition of natural antisense transcript to IRS2 and transcription factor E3 (TFE3).
Collard, Joseph; Khorkova Sherman, Olga, Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8.
Collard, Joseph; Sherman, Olga Khorkova, Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related disease by inhibition of natural antisense transcript to PYCR1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos; De Leon, Belinda, Treatment of sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a sirtuin (SIRT).
Collard, Joseph; Khorkova Sherman, Olga; De Leon, Belinda; Coito, Carlos; Hsiao, Jane H., Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2 (IRS2) related diseases by inhibition of natural antisense transcript to TFE3.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2(IRS2) related diseases by inhibition of natural antisense transcript to TFE3.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2.
Collard, Joseph; Khorkova Sherman, Olga, Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF.
Collard, Joseph; Sherman, Olga Khorkova, Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP.
Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of ‘C terminus of HSP7O-interacting protein’ (CHIP) related diseases by inhibition of natural antisense transcript to CHIP.
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