Compositions and medical devices utilizing bioabsorbable liquid polymers
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-031/74
A61K-047/30
출원번호
US-0112201
(2002-03-29)
등록번호
US-7326426
(2008-02-05)
발명자
/ 주소
Nathan,Aruna
Rosenblatt,Joel
Arnold,Steven C.
출원인 / 주소
Ethicon, Inc.
대리인 / 주소
Skula,Emil Richard
인용정보
피인용 횟수 :
15인용 특허 :
52
초록▼
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less t
The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40�� C., as determined by differential scanning calorimetry.
대표청구항▼
We claim: 1. A composition comprising: an effective amount of a bioactive agent, and a polymer comprising the reaction product of at least one polybasic acid selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid and diglycol
We claim: 1. A composition comprising: an effective amount of a bioactive agent, and a polymer comprising the reaction product of at least one polybasic acid selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid and diglycolic anhydride and at least one monoglyceride selected from the group consisting of monostearyl glycerol, monopalmitoyl glycerol, monomyrisitol glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauryl glycerol, monolinoleoyl glycerol and monooleoyl glycerol, said polymer comprising an aliphatic polyester backbone having pendant fatty acid ester groups and said polymer having a melting point less than about 25�� C., as determined by differential scanning calorimetry. 2. The composition of claim 1 wherein said polymer comprises a copolymer. 3. The composition of claim 2 wherein said copolymer comprises the reaction product of said monoglyceride and at least two of said polybasic acids. 4. The composition of claim 2 wherein said copolymer comprises the reaction product of said polybasic acid, and at least two of said monoglycerides. 5. The composition of claim 2 wherein said copolymer comprises the reaction product of a) said polybasic acid, b) said monoglyceride and c) at least one polyol selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,3-propanediol, bis-2-hydroxyethyl ether, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1,12-dodecanediol, other diols, linear poly(ethylene glycol), branched poly(ethylene glycol), linear poly(propylene glycol), branched poly(propylene glycol), linear poly(ethylene-co-propylene glycol)s and branched poly(ethylene-co-propylene glycol)s. 6. The composition of claim 1 wherein said bioactive agent is selected from the group consisting of antiinfectives, analgesics, anorexics, antihelmintics, antiarthritics, antiasthmatics, anticonvulsants, antidepressants, antidiuretics, antidiarrheals, antihistamines, antiinflammatory agents, antimigraine preparations, antinauseants, antineoplastics, antiparkinsonism drugs, antipruritics, antipsychotics, antipyretics, antispasmodics, anticholinergics, sympathomimetics, xanthine derivatives, calcium channel blockers, beta-blockers, antiarrhythmics, antihypertensives, diuretics, vasodilators, central nervous system stimulants, decongestants, hormones, steroids, hypnotics, immunosuppressives, muscle relaxants, parasympatholytics, psychostimulants, sedatives, tranquilizers, naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins, oligonucleotides, antibodies, antigens, cholinergics, chemotherapeutics, hemostatics, clot dissolving agents, radioactive agents and cystostatics. 7. The composition of claim 1 wherein said bioactive agent is risperidone. 8. The composition of claim 1 wherein said bioactive agent is erythropoietin. 9. The composition of claim 1 wherein said bioactive agent is rapamycin. 10. A composition comprising: an effective amount of a bioactive agent, and a polymer comprising the reaction product of succinic anhydride or succinic acid and at least one monoglyceride selected from the group consisting of monostearyl glycerol, monopalmitoyl glycerol, monomyrisitol glycerol, monocaproyl glycerol, monodecanoyl glycerol, monolauryl glycerol, monolinoleoyl glycerol and monooleoyl glycerol, said polymer comprising an aliphatic polyester backbone having pendant fatty acid ester groups and said polymer having a melting point less than about 25�� C., as determined by differential scanning calorimetry.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (52)
Bezwada Rao S. (Whitehouse Station NJ) Jamiolkowski Dennis D. (Long Valley NJ), Absorbable polyoxaesters.
Lundgren Dan (Askims Kyrkvag 5 S-436 51 Hovas SEX) Gottlow Jan (Klintasgatan 5 S-422 44 Hisings Backa SEX) Mathisen Torbjorn (Bandhagsplan 9 S-132 24 Bandhagen SEX), Bioresorbable material and an article of manufacture made of such material for medical use.
Casey ; Donald J. ; Gleckler ; George C., High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical compositio.
Jamiolkowski Dennis D. (Long Valley NJ) Bezwada Rao S. (Whitehouse Station NJ), Hydrogels of absorbable polyoxaesters containing amines or amido groups.
Scopelianos Angelo G. ; Arnold Steven C. ; Bezwada Rao S. ; Roller Mark B. ; Huxel Shawn T., Injectable microdipersions for soft tissue repair and augmentation.
Scopelianos Angelo G. (Whitehouse Station NJ) Arnold Steven C. (Sparta NJ) Bezwada Rao S. (Whitehouse Station NJ) Roller Mark B. (North Brunswick NJ) Huxel Shawn T. (Lakehurst NJ), Injectable microdispersions for soft tissue repair and augmentation.
Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Shalaby Shalaby W. (Anderson SC) Williams Bernard L. (Martinsville NJ), Liquid absorbable copolymers for parenteral applications.
Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Shalaby Shalaby W. (Anderson SC) Williams Bernard L. (Martinsville NJ), Liquid absorbable copolymers for parenteral applications.
Scopelianos Angelo G. (Whitehouse Station NJ) Bezwada Rao S. (Whitehouse Station NJ) Arnold Stephen C. (Franklin NJ) Gooding Richard D. (Easton PA), Liquid polymer filled envelopes for use as surgical implants.
Angelo G. Scopelianos ; Steven C. Arnold ; Rao S. Bezwada ; Mark B. Roller ; Shawn T. Huxel ; Robert J. Tannhauser, Microdispersions for coating surgical devices.
Gooch Jan W. (Gladstone MO) Bufkin B. George (Tipp City OH) Wildman Gary C. (Hattiesburg MS), Process for preparing coating binders from vegetable oil material.
Yamagata Yutaka,JPX ; Iga Katsumi,JPX ; Okada Hiroaki,JPX, Sustained releasable parenteral pharmaceutical preparations and method of producing the same.
Gruber Patrick Richard ; Kolstad Jeffrey John ; Witzke David Roy ; Hartmann Mark Henry ; Brosch Andrea Lee, Viscosity-modified lactide polymer composition and process for manufacture thereof.
Kelly, Brian M.; Jamiolkowski, Dennis D.; DeFelice, Christopher, Bioabsorbable polymeric compositions, processing methods, and medical devices therefrom.
Kelly, Brian M.; Jamiolkowski, Dennis D.; DeFelice, Christopher, Bioabsorbable polymeric compositions, processing methods, and medical devices therefrom.
Kelly, Brian M.; Jamiolkowski, Dennis D.; DeFelice, Christopher, Bioabsorbable polymeric compositions, processing methods, and medical devices therefrom.
Lu, Helen H.; Moffat, Kristen L.; Levine, William N., Biomimmetic nanofiber scaffold for soft tissue and soft tissue-to-bone repair, augmentation and replacement.
Lu, Helen H.; Spalazzi, Jeffrey; Dionisio, Kathie, Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of bone.
O'Mahony, Donal; Garigapati, Venkat R.; Sun Wai, Adrian; Hess, Brian; Murphy, Matthew E., Post irradiation shelf-stable dual paste direct injectable bone cement precursor systems and methods of making same.
O'Mahony, Donal; Garigapati, Venkat R.; Sun Wai, Adrian; Hess, Brian; Murphy, Matthew E., Post irradiation shelf-stable dual paste direct injectable bone cement precursor systems and methods of making same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.