[특허]Rapid microbial detection and antimicrobial susceptibility testing

Rapid microbial detection and antimicrobial susceptibility testing 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/53
출원번호	US-0303803 (2005-12-16)
등록번호	US-7341841 (2008-03-11)
발명자 / 주소	Metzger,Steven W. Howson,David C. Goldberg,David A. Buttry,Daniel A.
출원인 / 주소	Accelr8 Technology Corporation
대리인 / 주소	Dorsey & Whitney LLP
인용정보	피인용 횟수 : 41 인용 특허 : 42

초록

A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.

대표청구항 ▼

We claim: 1. A method for measuring the growth of a plurality of individual microorganisms in a sample comprising: contacting said sample with a biosensor comprising: a concentration module; at least one detection surface; and concentrating said individual microorganisms onto said detection surface, wherein each said individual microorganism binds to said detection surface in spatially discrete sites; allowing said individual microorganisms to grow for a first period of time; and detecting growth of individual microorganisms as an indication of the presence of said microorganisms. 2. A method according to claim 1 further comprising adding at least one bioactive agent during said growth conditions. 3. A method according to claim 2 wherein a plurality of bioactive agents are added. 4. A method according to claim 2 or 3 wherein said agent(s) are added after a first growth period. 5. A method according to claim 4 further comprising measuring growth of said individual microorganisms prior to said addition of said agent(s); and measuring growth of said individual microorganisms after a second growth period in the presence of said agent(s). 6. A method according to claim 2 or 3 wherein said agent(s) are added prior to said first growth period. 7. A method for measuring the growth of a plurality of individual microorganisms in a sample comprising: contacting said sample with a biosensor comprising: a concentration module; and at least one detection surface; concentrating said individual microorganisms onto said detection surface, wherein each said individual microorganism binds to said detection surface in spatially discrete sites; allowing said individual microorganisms to a grow for a first period of time; adding at least one bioactive agent to said microorganisms; allowing said individual microorganisms to grow for a second period of time; detecting growth of individual microorganisms as an indication of the presence of said microorganisms. 8. A method according to claim 7 wherein a plurality of bioactive agents are added. 9. A method according to claim 1 or 7 wherein said concentration module utilizes a method selected from the group consisting of electrophoresis, centrifugation, filtration and dielectrophoresis. 10. A method according to claim 1 or 7 wherein said detection surface comprises a plurality of individual detection sites. 11. A method according to claim 1 or 7 wherein said detection surface comprises selective capture ligands. 12. A method according to claim 1 or 7 wherein said detection surface comprises a nonspecific surface. 13. A method according to claim 11 wherein said plurality of individual detection sites each comprise a different selective capture ligand. 14. A method according to claim 11 wherein said plurality of individual detection sites each comprise a non-specific surface. 15. A method according to claim 1 or 7 wherein the identity of at least one microorganism is established. 16. A method according to claim 1 or 7 wherein said detecting is done by monitoring alterations in the physical area on said surface associated with an individual microorganism as it grows. 17. A method according to claim 1 or 7 wherein said detecting is done by detecting the presence of daughter cells at said spatially discrete sites. 18. A method according to claim 1 or 7 wherein said detecting further comprises adding a label, and said detection is done by monitoring alterations in the binding of said label to said individual microorganism as it grows. 19. A method according to claim 17 wherein said label is a mortal stain. 20. A method according to claim 1 or 7 wherein said biosensor comprises a plurality of channels, each comprising a detection surface. 21. A method according to claim 1, 7 or 19 wherein said biosensor further comprises a plurality of storage modules. 22. A method according to claim 20 wherein said storage modules each comprise a different bioactive agent. 23. A method of diagnosing a microbial infection in a patient comprising: providing a matrix of time versus kill curves for a panel of antimicrobial agents against a panel of microorganisms; contacting a sample from said patient with a biosensor comprising: a concentration module; and at least one detection surface; concentrating patient individual microorganisms from said sample on said detection surface, wherein each said patient individual microorganism individually binds to said detection surface in spatially discrete sites; detecting the growth of said patient individual microorganisms in the presence of said panel of antimicrobial agents; identifying at least one of said patient individual microorganisms by comparing its growth to said matrix. 24. A method for the identification of individual microorganisms in a sample comprising: contacting said sample with a biosensor comprising: a concentration module; and at least one detection surface; concentrating said individual microorganisms onto said detection surface, wherein each said individual microorganism individually binds to said detection surface in spatially discrete sites; subjecting said individual microorganisms to a first growth period; adding at least one antimicrobial agent to said detection surface; subjecting said individual microorganisms to a second growth period; detecting alterations in growth of individual microorganisms after the addition of said agent; and identifying at least one of said individual microorganisms on the basis of susceptibility to said agent. 25. A method according to claim 1, wherein the detection of one or more divisions of individual microorganisms into two microorganisms is an indication of the presence of said microorganisms.

이 특허에 인용된 특허 (42)

Ackley Donald E. ; Swanson Paul D. ; Graham Scott O. ; Mather Elizabeth L. ; LeClair Timothy L. ; Butler William F., Advanced active electronic devices for molecular biological analysis and diagnostics.
상세보기
Southern Edwin,GBX, Analying polynucleotide sequences.
상세보기
Simpson John W. ; Rothberg Jonathan M. ; Went Gregory T., Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments.
상세보기
Wilding Peter ; Kricka Larry J. ; Zemel Jay N., Apparatus for the detection of an analyte utilizing mesoscale flow systems.
상세보기
Botsford James L., Assay for chemicals.
상세보기
Blackburn Gary ; Creager Stephen E. ; Fraser Scott ; Irvine Bruce D. ; Meade Thomas J. ; O'Connor Stephen D. ; Terbrueggen Robert H. ; Vielmetter Jost G. ; Welch Thomas W., Binding acceleration techniques for the detection of analytes.
상세보기
Bashir, Rashid; Gomez, Rafael; Ladisch, Michael R., Biosensor and related method.
상세보기
Guohong Wang ; Thomas Foley, Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples.
상세보기
Matson, Robert S., Conductive microplate.
상세보기
Wilding, Peter; Kricka, Larry J.; Zemel, Jay N., Device and method for the detection of an analyte utilizing mesoscale flow systems.
상세보기
Ericsson Magnus (Stockholm SEX) Bolmstrm Anne (Åkersberga SEX), Device for susceptibility testing of microorganisms.
상세보기
Haugland Richard P. (Eugene OR) MacCoubrey Ian C. (Blacksburg VA) Moore Patrick L. (West Roxbury MA), Dual-fluorescence cell viability assay using ethidium homodimer and calcein AM.
상세보기
Ozkan, Mihrimah; Esener, Sadik; Bhatia, Sangeeta, Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells.
상세보기
Caldwell Karin D. (Salt Lake City UT) Gao Yu-Shu (Salt Lake City UT), Electrical field-flow fractionation using redox couple added to carrier fluid.
상세보기
Mao, Guoqiano; Metzger, Steven W.; Lochhead, Michael J., Functional surface coating.
상세보기
Claverys Jean-Pierre (Toulouse FRX) Mabilat Claude (Villeurbanne FRX), Genomic DNA fragment of Streptococcus pneumoniae, hybridization probe, amplification primer, reagent and metho.
상세보기

Ohnishi Haruo (Funabashi JPX) Yamaguchi Kazuo (Koganei JPX) Suzuki Yasuo (Kawaguchi JPX) Mochida Ei (Tokyo JPX) Mochida Nobuo (Tokyo JPX), Glycoproteins and processes for their production.
상세보기

Yuan Yu-Kang,TWX, Immobilization of microbial cells and enzymes in calcium alginate-polyethylene glycol-polyethylene imide beads.
상세보기

Jing Cheng CN; Lei Wu ; Michael J. Heller ; Ed Sheldon ; Jonathan Diver ; James P. O'Connell ; Dan Smolko ; Shila Jalali ; David Willoughby, Integrated portable biological detection system.
상세보기

Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of an array of polymers.
상세보기

Sielaff Bruce H. (Gales Ferry CT) Praglin Julius (East Lyme CT) McKie ; Jr. James E. (Ledyard CT) Longhenry David K. (East Lyme CT) Curtiss Alan C. (Old Lyme CT) Bidwell Charles B. (Madison CT), Method and apparatus for identifying microorganisms.
상세보기

Malcus-Vocanson Carine,FRX ; Perron Herve,FRX ; Mandrand Bernard,FRX, Method for detecting and/or quantifying a gliotoxic factor.
상세보기

Waters John R. (Towson MD), Method for detecting bacteria.
상세보기

Kohne David E. (La Jolla CA), Method for detecting, identifying, and quantitating organisms and viruses.
상세보기

Stephen C. Wardlaw ; Robert A. Levine, Method for determining the effects of a growth-altering agent on a microbial colony.
상세보기

Heller Michael James ; Sosnowski Ronald George, Method for fingerprinting utilizing an electronically addressable array.
상세보기

Sosnowski Ronald G. ; Butler William F. ; Tu Eugene ; Nerenberg Michael I. ; Heller Michael J. ; Edman Carl F., Methods and procedures for molecular biological analysis and diagnostics.
상세보기

Heller Michael J., Methods for electronic stringency control for molecular biological analysis and diagnostics.
상세보기

Elaine M. Weidenhammer ; Ling Wang ; Xiao Xu ; Michael J. Heller ; Brenda F. Kahl, Methods for gene expression monitoring on electronic microarrays.
상세보기

Heller Michael James ; O'Connell James Patrick ; Juncosa Robert David ; Sosnowski Ronald George ; Jackson Thomas Ratcliffe, Methods for hybridization analysis utilizing electrically controlled hybridization.
상세보기

Martinsky Richard S, Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture.
상세보기

Wilkins Judd R. (Hampton VA) Stoner Glenn E. (Charlottesville VA), Microbial detection and enumeration apparatus.
상세보기

Frazier A. Bruno ; Caldwell Karin D.,SEX ; Gale Bruce K., Micromachined electrical field-flow fractionation system.
상세보기

Kapur, Ravi; Adams, Terri, Miniaturized cell array methods and apparatus for cell-based screening.
상세보기

Egen Ned B. (Tucson AZ) Twitty Garland E. (Tucson AZ) Sammons David W. (Tucson AZ) Sharnez Rizwan (Tucson AZ), Multi-modality electrical separator apparatus and method.
상세보기

Smithwick ; Jr. Edward L. (Indianapolis IN) Frederickson Robert C. A. (Indianapolis IN) Shuman Robert T. (Greenwood IN), Pharmacologically active peptides.
상세보기

Ookuma Shigeru (Hofu) Igarashi Kouei (Osaka) Hara Masami (Hofu) Aso Kazuhiro (Ibaraki) Yoshidome Hideo (Kishiwada) Nakayama Hiroshi (Hirakata) Suzuki Keizo (Osaka) Nakajima Kazuhiko (Osaka JPX), Porous ion-exchanged fine cellulose particles, method for production thereof, and affinity carrier.
상세보기

Gayral Jean-Pierre (Lagnieu FRX), Process of rapid identification of bacteria of the genus Streptococcus.
상세보기

Susan R. Mikkelsen CA; Peter Ertl CA, Rapid electrochemical assay for antibiotic and cytotoxic drug susceptibility in microorganisms.
상세보기

Johnston Judith ; Felland Tracy ; Bascomb Shoshana ; Godsey James H., Rapid inducible beta-lactamase screen test.
상세보기

Boeufgras, Jean-Marc; Lazzarini, Annie; Peyret, Michel, System for validation and interpreting results of antimicrobial susceptibility tests of micro-organisms.
상세보기

Kayyem Jon Faiz ; Blackburn Gary ; O'Connor Stephen D., Systems for electrophoretic transport and detection of analytes.
상세보기

이 특허를 인용한 특허 (41)

Kopelman, Raoul; Burns, Mark A.; Li, Yunzi, Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes.
상세보기

McNaughton, Brandon H.; Kinnunen, Paivo; Kopelman, Raoul; Hunt, Alan; Clarke, Roy; Sinn, Irene; Elbez, Remy; Albertson, Theodore, Asynchronous magnetic bead rotation sensing systems and methods.
상세보기

Schubert, Mathias M.; Hofmann, Tino; Hage, David S.; Pfaunmiller, Erika; Herzinger, Craig M.; Woollam, John A.; Schoeche, Stefan, Birefringence imaging chromatography based on highly ordered 3D nanostructures.
상세보기

Gordon, Julian; Gandhi, Prasanthi, Electrokinetic device for capturing assayable agents in a dielectric fluid.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, High reflectivity retro-reflective marker.
상세보기

Richards, William L.; Ashby, Austin; Ketterer, Matthew; Marshall, Kevin; Harrison, Josh; Mette, Matthew; Richards, Paul; Showalter, Wayne; Cote, Jasmin; Halbert, Phillip C.; Bourgeois, Solene; Metzger, Steven W.; Hance, Ken; Mensack, Meghan; Michel, Carlos; Allers, Elke; Gamage, Dulini; Prisbrey, Landon; Gusyatin, Oleg; Shamsheyeva, Alena; Turng, Ben; Ghusson, Andrew; Reinhardt, Kurt, Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing.
상세보기

Richards, William L.; Ashby, Austin; Ketterer, Matthew; Marshall, Kevin; Harrison, Josh; Mette, Matthew; Richards, Paul; Showalter, Wayne; Cote, Jasmin; Halbert, Phillip C.; Bourgeois, Solene; Metzger, Steven W.; Hance, Ken; Mensack, Meghan; Michel, Carlos; Allers, Elke; Gamage, Dulini; Prisbrey, Landon; Gusyatin, Oleg; Shamsheyeva, Alena; Turng, Ben; Ghusson, Andrew; Reinhardt, Kurt, Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing.
상세보기

Heil, James R.; Lochhead, Michael J.; Moll, Kevin D.; Myatt, Christopher J., Integrated sample preparation and analyte detection.
상세보기

Kopelman, Raoul; Elbez, Remy; Hecht, Ariel; McNaughton, Brandon H., Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Marker sphere including edged opening to aid in molding.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Material thickness control over retro-reflective marker.
상세보기

Prisbrey, Landon; Blackmore, Elise; Hance, Kenneth R.; Metzger, Steven W.; Marshall, Kevin, Membrane-assisted purification.
상세보기

Sauer-Budge, Alexis Fay; Sharon, Andre; Kalashnikov, Maxim; Wirz, Holger, Method and device for rapid detection of bacterial antibiotic resistance/susceptibility.
상세보기

Sauer-Budge, Alexis; Sharon, Andre; Kalashnikov, Maxim; Wirz, Holger, Method and device for rapid detection of bacterial antibiotic resistance/susceptibility.
상세보기

Zeng, Xiangqun; Shen, Zhihong, Method of microorganism detection using carbohydrate and lectin recognition.
상세보기

Stern, Eric; Vacic, Aleksandar; Spears, Benjamin; Flentie, Kelly; Flyer, Alec, Methods for rapid antibiotic susceptibility testing.
상세보기

Chou, Chia-Fu; Leonardo, Lesser-Rojas; Chu, Ming-Lee; Erbe, Andreas, Microfluidic systems and devices for molecular capture, manipulation, and analysis.
상세보기

Anker, Jeffrey; Behrend, Caleb; Kopelman, Raoul; McNaughton, Brandon, Modulated physical and chemical sensors.
상세보기

McNaughton, Brandon H.; Kinnunen, Paivo; Younger, John G., Multi-mode separation for target detection.
상세보기

McNaughton, Brandon H.; Kopelman, Raoul; Torres-Isea, Ramon; Clarke, Roy, Non-linear rotation rates of remotely driven particles and uses thereof.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Packaging for retro-reflective markers.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Packaging for retro-reflective markers.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas Abraham, Packaging for retro-reflective markers.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Protective cover for medical device having adhesive mechanism.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Radiopaque core.
상세보기

Kwon, Sunghoon; Jung, Yong-Gyun; Choi, Jung Il; Na, Hun Jong, Rapid antibiotic susceptibility testing system based on bacterial immobilization using gelling agent, antibiotic diffusion and tracking of single bacterial cells.
상세보기

Kwon, Sunghoon; Jung, Yong-Gyun; Choi, Jung Il; Na, Hun Jong, Rapid antibiotic susceptibility testing system based on bacterial immobilization using gelling agent, antibiotic diffusion and tracking of single bacterial cells.
상세보기

Kwon, Sunghoon; Jung, Yong-Gyun; Choi, Jung Il; Na, Hun Jong, Rapid antibiotic susceptibility testing system based on bacterial immobilization using gelling agent, antibiotic diffusion and tracking of single bacterial cells.
상세보기

Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
상세보기

Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
상세보기

Metzger, Steven W.; Hance, Kenneth Robert, Rapid cell purification systems.
상세보기

Shamsheyeva, Alena; Howson, David C.; Metzger, Steven W., Rapid determination of microbial growth and antimicrobial susceptibility.
상세보기

Metzger, Steven W.; Howson, David C.; Goldberg, David A.; Buttry, Daniel A., Rapid microbial detection and antimicrobial susceptibility testing.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Reflective marker being radio-opaque for MRI.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Reflective marker with alignment feature.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Retro-reflective marker including colored mounting portion.
상세보기

Shafer, Helen Zinreich; Zinreich, David Alan; Crumb, Douglas, Retro-reflective marker with snap on threaded post.
상세보기

Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
상세보기

Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
상세보기

Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
상세보기

Marcelpoil, Raphael R.; Orny, Cedrick; Morel, Didier, System and method for image acquisition using supervised high quality imaging.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Rapid microbial detection and antimicrobial susceptibility testing 원문보기

초록

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (42)

이 특허를 인용한 특허 (41)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Rapid microbial detection and antimicrobial susceptibility testing 원문보기

초록

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (42)

이 특허를 인용한 특허 (41)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트