초록 ▼

A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having

A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.

대표청구항 ▼

What is claimed is: 1. A local renal infusion system for treating a renal system in a patient from a location within the abdominal aorta associated with first and second flow paths within an outer region of abdominal aortic blood flow generally along the abdominal aorta wall and into first and seco

What is claimed is: 1. A local renal infusion system for treating a renal system in a patient from a location within the abdominal aorta associated with first and second flow paths within an outer region of abdominal aortic blood flow generally along the abdominal aorta wall and into first and second renal arteries, respectively, via their corresponding first and second renal ostia along an abdominal aorta wall in the patient, comprising: a local injection assembly comprising a first infusion tube having a distal end, a proximal end, and a first injection port disposed between the distal end and the proximal end, a second infusion tube having a distal end, a proximal end, and a second injection port disposed between the distal end and the proximal end, and a central catheter tube with first and second injection ports; wherein the distal end of the first infusion tube and the distal end of the second infusion tube are attached to the central catheter tube, such that when the first infusion tube and the second infusion tube are in an expanded configuration the first infusion tube and the second infusion tube bow outward away from the central catheter tube, and when the first infusion tube and the second infusion tube are in a retracted configuration the first infusion tube and the second infusion tube straighten inward toward the central catheter tube; wherein the local injection assembly is adapted to be positioned at the location with the first and second injection ports at first and second respective positions, respectively, corresponding with the first and second flow paths; wherein the local injection assembly is adapted to be fluidly coupled to a source of fluid agent externally of the patient when the local injection assembly is positioned at the location; and wherein the local injection assembly is adapted to inject a volume of fluid agent from the source, through the first and second injection ports at the first and second positions, respectively, and bi-laterally into the first and second renal arteries, also respectively, via the respective corresponding first and second renal ostia without substantially altering abdominal aorta flow along the location. 2. The system of claim 1, wherein the local injection assembly is adapted to inject the volume of fluid agent into the first and second flow paths such that the injected volume flows substantially only into the first and second renal arteries without substantially diverting one region of aortic blood flow into another region of aortic blood flow. 3. The system of claim 1, wherein the local injection assembly is adapted to inject the volume of fluid agent into the first and second flow paths such that the injected volume flows substantially only into the first and second renal arteries without substantially occluding abdominal aortic blood flow. 4. The system of claim 1, wherein the local injection assembly is adapted to inject the volume of fluid agent into the first and second flow paths such that the injected volume flows substantially only into the first and second renal arteries without substantially isolating the first or second flow paths from adjacent flow paths at the location. 5. The system of claim 1, further comprising: a delivery member with a proximal end portion and a distal end portion with a longitudinal axis; wherein the local injection assembly comprises first and second injection members with first and second injection ports, respectively; wherein the local injection assembly is adapted to extend from the distal end portion of the delivery member and is adjustable between a first configuration and a second configuration; wherein the local injection assembly in the first configuration is adapted to be delivered by the delivery member to the location; and wherein the local injection assembly at the location is adjustable from the first configuration to the second configuration such that the first and second first injection members are radially extended from the longitudinal axis with the first and second injection ports located at the first and second positions, respectively, at the first and second flow paths. 6. The system of claim 1, wherein: the local injection assembly further comprises an elongate body with a longitudinal axis and that is adapted to be positioned at the location; the first and second injection members in the first configuration have first radial positions relative to the longitudinal axis; and the first and second injection members in the second configuration have second radial positions that are radially extended from the longitudinal axis relative to the first radial position. 7. The system of claim 6, wherein: the first and second injection members are located on opposite respective sides of the elongate body around a circumference of the elongate body. 8. The system of claim 7, wherein: each of the first and second injection members extends between proximal and distal respective locations on each of the opposite respective sides of the elongate body; and in the second configuration the first and second injection members are biased outward from the elongate body between the respective proximal and distal respective locations. 9. The system of claim 8, wherein: each of the first and second injection members has a length that is longer than a distance between the respective proximal and distal locations; each respective proximal location comprises a port; each of the first and second injection members in the first configuration has a proximal section that extends proximally within the respective port at the respective proximal location and into the elongate body; and the proximal section of each of the first and second injection members in the second configuration is advanced distally through the port to extend from the elongate body. 10. The system of claim 5, further comprising: first and second markers located along the first and second injection members, respectively, at locations generally corresponding with the first and second injection ports; and wherein each of the first and second markers is adapted to indicate to an operator externally of the patient the locations of the first and second injection ports to assist their delivery to the first and second positions, respectively. 11. The system of claim 10, wherein the first and second markers comprise radiopaque markers.