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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0688312 (2003-10-17) |
등록번호 | US-7390667 (2008-06-24) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 49 인용 특허 : 459 |
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
What is claimed is: 1. A method for determining a glucose concentration of a blood sample, comprising the steps of: a) applying a signal having an AC component to the blood sample; b) measuring an AC phase angle response to the signal; and c) determining the glucose concentration using the AC phase
What is claimed is: 1. A method for determining a glucose concentration of a blood sample, comprising the steps of: a) applying a signal having an AC component to the blood sample; b) measuring an AC phase angle response to the signal; and c) determining the glucose concentration using the AC phase angle response. 2. The method of claim 1, wherein step (c) comprises determining an effective phase angle, which is proportional to the glucose concentration, using the AC phase angle response. 3. The method of claim 2, wherein step (c) comprises determining the effective phase angle using description="In-line Formulae" end="lead"Peff=(Φ/Γ)-γ description="In-line Formulae" end="tail" Where: Peff is the effective phase angle, Φ is the AC phase angle response, and Γ and γ are constants. 4. The method of claim 3, wherein step (a) comprises applying a signal having a frequency of 2 kHz or below. 5. The method of claim 2, wherein step (c) further comprises determining the glucose concentration using description="In-line Formulae" end="lead"PRED=(a0+hct1Hest+hct2H est2+tau1dT+tau2dT2)+(a1 Peff)(1+hct3Hest+hct4Hest 2)(1+tau3dT+tau4dT2) description="In-line Formulae" end="tail" Where: PRED is the glucose concentration, Peff is the effective phase angle, a0, a1, hct, hct2, hct3, hct4, tau1, tau2, tau3 and tau4 are constants, Hest is a hematocrit value of the blood sample, and dT is the temperature. 6. The method of claim 1, wherein step (a) comprises applying a signal having a frequency of 2 kHz or below. 7. The method of claim 1, wherein step (a) comprises applying a signal having a frequency of 1 kHz or below. 8. The method of claim 1, wherein step (a) comprises applying a signal having a frequency of 200 Hz or below. 9. The method of claim 1, wherein the signal is an AC signal. 10. The method of claim 1, wherein the AC component of the signal has a frequency not less than 1 Hz and not greater than 20 kHz. 11. A method of determining a glucose concentration of a biological fluid sample, comprising: (a) applying a signal having an AC component to the sample; (b) measuring an AC phase angle response to the signal; and (c) determining the glucose concentration based upon the AC phase angle response and a predetermined correlation between the AC phase angle response and the glucose concentration. 12. The method of claim 11, wherein the biological fluid is blood. 13. The method of claim 12, wherein step (c) comprises determining an effective phase angle, which is proportional to the glucose concentration, using the AC phase angle response. 14. The method of claim 13, wherein step (c) comprises determining the effective phase angle using description="In-line Formulae" end="lead"Peff=(Φ/Γ)-γ description="In-line Formulae" end="tail" Where: Peff is the effective phase angle, Φ is the AC phase angle response, and Γ and γ are constants. 15. The method of claim 14, wherein step (a) comprises applying a signal having a frequency of 2 kHz or below. 16. The method of claim 13, wherein step (c) further comprises determining the glucose concentration using description="In-line Formulae" end="lead"PRED=(a0+hct1Hest+hct2H est2+tau1dT+tau2dT2)+(a1 Peff)(1+hct3Hest+hct4Hest 2)(1+tau3dT+tau4dT2) description="In-line Formulae" end="tail" Where: PRED is the glucose concentration, Peff is the effective phase angle, a0, a1, hct, hct2, hct3, hct4, tau1, tau2, tau3 and tau4 are constants, Hest is a hematocrit value of the blood sample, and dT is the temperature. 17. The method of claim 11, wherein step (a) comprises applying a signal having a frequency of 2 kHz or below. 18. The method of claim 11, wherein step (a) comprises applying a signal having a frequency of 1 kHz or below. 19. The method of claim 11, wherein step (a) comprises applying a signal having a frequency of 200 Hz or below. 20. The method of claim 11, wherein the signal is an AC signal. 21. The method of claim 11, wherein the AC component of the signal has a frequency not less than 1 Hz and not greater than 20 kHz. 22. A method of determining a glucose concentration of a test sample comprising: (a) applying a signal having an AC component to the sample; (b) measuring an AC phase angle response to the signal; and (c) determining the glucose concentration using the first AC phase angle response and a predetermined compensation factor. 23. The method of claim 22, wherein the predetermined compensation factor accounts for a test sample temperature. 24. The method of claim 22, wherein the test sample is blood. 25. The method of claim 24, wherein the predetermined compensation factor accounts for a test sample hematocrit value. 26. The method of claim 24, wherein the predetermined compensation factor accounts for a test sample temperature and a test sample hematocrit value. 27. The method of claim 24, wherein step (c) comprises determining an effective phase angle, which is proportional to the glucose concentration, using the AC phase angle response. 28. The method of claim 27, wherein step (c) comprises determining the effective phase angle using description="In-line Formulae" end="lead"Peff=(Φ/Γ)-γ description="In-line Formulae" end="tail" Where: Peff is the effective phase angle, Φ is the AC phase angle response, and Γ and γ are constants. 29. The method of claim 28, wherein step (a) comprises applying a signal having a frequency of 2 kHz or below. 30. The method of claim 27, wherein step (c) further comprises determining the glucose concentration using description="In-line Formulae" end="lead"PRED=(a0+hct1Hest+hct2H est2+tau1dT+tau2dT2)+(a1 Peff)(1+hct3Hest+hct4Hest 2)(1+tau3dT+tau4dT2) description="In-line Formulae" end="tail" Where: PRED is the glucose concentration, Peff is the effective phase angle, a0, a1, hct, hct2, hct3, hct4, tau1, tau2, tau3 and tau4 are constants, Hest is a hematocrit value of the blood sample, and dT is the temperature. 31. The method of claim 22, wherein step (a) comprises applying a signal having a frequency of 2 kHz or below. 32. The method of claim 22, wherein step (a) comprises applying a signal having a frequency of 1 kHz or below. 33. The method of claim 22, wherein step (a) comprises applying a signal having a frequency of 200 Hz or below. 34. The method of claim 22, wherein the signal is an AC signal. 35. The method of claim 22, wherein the AC component of the signal has a frequency not less than 1 Hz and not greater than 20 kHz. 36. A method for determining a hematocrit value of a blood sample, comprising the steps of: a) applying at least one signal having an AC component to the blood sample, wherein said at least one signal comprises at least two frequencies applied at least partially simultaneously; b) measuring at least one AC phase angle response to respective ones of the at least one signal; and c) determining the hematocrit value using the at least one AC phase angle response. 37. The method of claim 36, wherein said at least one signal comprises at least four frequencies. 38. The method of claim 37, wherein said at least four frequencies are applied at least partially simultaneously. 39. A method for determining a hematocrit value of a blood sample, comprising the steps of: a) applying at least one signal having an AC component to the blood sample; b) measuring at least one AC phase angle response to respective ones of the at least one signal; and c) determining the hematocrit value using the at least one AC phase angle response, wherein said at least one signal comprises n signals, and wherein step (c) comprises determining the hematocrit value using description="In-line Formulae" end="lead"Hest=c0+c1Φ1 . . . cnΦndescription="In-line Formulae" end="tail" Where: Hest is the hematocrit value, c0, c1 . . . cn are constants, and Φ1 . . . Φn are respective AC phase angle responses to each of the n signals. 40. A method for determining a hematocrit value of a blood sample, comprising the steps of: (a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; and (e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response using description="In-line Formulae" end="lead"Hest=c0+c1Φ1 +c2Φ2description="In-line Formulae" end="tail" Where: Hest is the hematocrit value, c0, c1 and c2 are constants, and Φ1 and Φ2 are respective AC phase angle responses to the first and second signals. 41. The method of claim 40 wherein the first frequency is about 10 kHz and the second frequency is about 20 kHz. 42. The method of claim 40, further comprising the steps of: (f) applying a third signal having an AC component to the blood sample, the third signal having a third frequency; (g) measuring a third AC phase angle response to the third signal; (h) applying a fourth signal having an AC component to the blood sample, the fourth signal having a fourth frequency; and (i) measuring a fourth AC phase angle response to the fourth signal; (j) wherein the determining the hematocrit value is based upon the third phase angle response and the fourth phase angle response, and wherein the third frequency is about 2 kHz and the fourth frequency is about 1 kHz. 43. The method of claim 42, wherein the first frequency, the second frequency, the third frequency and the fourth frequency are applied at least partially simultaneously. 44. A method for determining a hematocrit value of a blood sample, comprising the steps of: (a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; and (e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response, wherein the first frequency and the second frequency are applied at least partially simultaneously. 45. A method for determining a hematocrit value of a blood sample, comprising the steps of: (a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; (e) applying a third signal having an AC component to the blood sample, the third signal having a third frequency; (f) measuring a third AC phase angle response to the third signal; (g) applying a fourth signal having an AC component to the blood sample, the fourth signal having a fourth frequency; and (h) measuring a fourth AC phase angle response to the fourth signal; (i) wherein the determining the hematocrit value is further based upon the third phase angle response and the fourth phase angle response, using description="In-line Formulae" end="lead"Hest=c0+c1Φ1+c2 Φ2+c3Φ3+c4Φ4 description="In-line Formulae" end="tail" Where: Hest is the hematocrit value, c0, c1, c2, c3, c4 are constants, and Φ1, Φ2, Φ3, Φ4 are respective AC phase angle responses to the first, second, third and fourth signals. 46. A method for determining a hematocrit value of a blood sample, comprising the steps of: a) applying at least one signal having an AC component to the blood sample, wherein the AC component comprises a frequency between about 1 kHz and about 20 kHz; b) measuring at least one AC phase angle response to respective ones of the at least one signal; and c) determining the hematocrit value using the at least one AC phase angle response. 47. A method for determining a hematocrit value of a blood sample, comprising the steps of: (a) applying a first signal having an AC component to the blood sample, the first signal having a first frequency between about 1 kHz and about 20 kHz; (b) measuring a first AC phase angle response to the first signal; (c) applying a second signal having an AC component to the blood sample, the second signal having a second frequency; (d) measuring a second AC phase angle response to the second signal; and (e) determining the hematocrit value based at least in part upon the first phase angle response and the second phase angle response.
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