[특허]Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof

[미국특허] Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07H-021/04 C07H-021/00
출원번호	US-0126798 (2005-05-10)
등록번호	US-7399849 (2008-07-15)
발명자 / 주소	Chatterjee,Malaya Foon,Kenneth A. Chatterjee,Sunil K.
출원인 / 주소	University of Kentucky Research Foundation
대리인 / 주소	Sitites & Harbison PLLC
인용정보	피인용 횟수 : 0 인용 특허 : 27

초록 ▼

The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG--associated tumors.

대표청구항 ▼

What is claimed is: 1. An isolated polynucleotide comprising a sequence encoding a polypeptide having immunological activity of monoclonal anti-idiotype antibody having ATCC No. 12020, wherein the polypeptide comprises the entire variable regions of the antibody. 2. The isolated polynucleotide of claim 1, wherein a portion of the encoding sequence comprises the sequence of SEQ ID NO:1. 3. The isolated polynucleotide of claim 1, wherein a portion of the encoding sequence comprises the sequence of SEQ ID NO:3.

이 특허에 인용된 특허 (27) 인용/피인용 타임라인 분석

Raychaudhuri Syamal (3716 Carmel View Rd. San Diego CA 92130), Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen.
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Shimada Shizuo (Mobara JPX) Sudo Tadashi (Mobara JPX) Inoue Hitoshi (Mobara JPX) Furutani Yoshio (Yokohama JPX) Fujisawa Yoshikazu (Kamakura JPX), Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation cont.
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Gourlie Brian B. ; Rixon Mark W. ; Mezes Peter S., Family of anti-carcinoembryonic antigen chimeric antibodies.
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Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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Houghton Alan N. (New York CT) Brooks Hannah (New York CT) Cote Richard J. (New York CT) Oettgen Herbert F. (New Canaan CT) Old Lloyd J. (New York NY), Human monoclonal antibodies from lymphocytes of patients with malignant melanoma.
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Bendig Mary M.,GBX ; Leger Olivier J.,GBX ; Saldanha Jose,GBX ; Jones S. Tarran,GBX ; Yednock Ted A., Humanized antibodies against leukocyte adhesion molecule VLA-4.
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Valenzuela Pablo D. T. (San Francisco CA) Kuo George (San Francisco CA) Barr Philip J. (Orinda CA), Hybrid particle immunogens.
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Hakomori Sen-itiroh (Mercer Island WA), Hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside.
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Koprowski Hilary (Wynnewood PA) Herlyn Dorothee (Wynnewood PA) DeFreitas Elaine C. (Villanova PA), Induction of antibody response to solid tumors with anti-idiotype antibodies.
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Nudelman Edward (Seattle WA) Singhal Anil (Seattle WA) Clausen Henrik (Seattle WA) Hakomori Sen-itiroh (Seattle WA), Method for the production of monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides.
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Chatterjee Malaya ; Foon Kenneth A., Methods of delaying development of HMFG-associated tumors using anti-idiotype antibody 11D10.
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Hellstrm Ingegerd (Seattle WA) Brown Joseph P. (Seattle WA) Hellstrm Karl E. (Seattle WA) Horn Diane (Seattle WA) Linsley Peter (Seattle WA), Monoclonal antibodies for treatment of human non-small cell lung carcinomas.
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Albino Anthony (New York NY) Lloyd Kenneth (Bronx NY) Ikeda Hisami (Asahikawa NY JPX) Old Lloyd (New York NY), Monoclonal antibodies to melanoma cells.
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Reisfeld Ralph A. (La Jolla CA) Schulz Gregor (San Diego CA), Monoclonal antibody directed to human ganglioside GD₂.
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Hellstrom Ingegerd (Seattle WA) Hellstrom Karl E. (Seattle WA), Monoclonal antibody to human carcinomas.
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Hellstrom Karl E. (Seattle WA) Hellstrom Ingegerd (Seattle WA) Marquardt Hans (Mercer Island WA) Yoneyama Yoshitaka (Bellevue WA), Monoclonal antibody to novel antigen associated with human tumors.
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Irie Reiko F. (Los Angeles CA), Murine monoclonal anti-idiotype antibodies.
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Levenson Corey H. (Oakland CA) Mullis Kary B. (Kensington CA), Precursor to nucleic acid probe.
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Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
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Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences.
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Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
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Burke Rae L. (San Francisco CA) Pachl Carol (Oakland CA) Valenzuela Pablo D. T. (San Francisco CA), Recombinant herpes simplex gb-gd vaccine.
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Ribi Edgar E. (Hamilton MT) Schwartzman Steven M. (Stevensville MT) Cantrell John L. (Hamilton MT), Refined detoxified endotoxin product.
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Kensil Charlotte A. (Milford MA) Marciani Dante J. (Hopkinton MA), Saponin adjuvant.
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Hellstrom Ingegerd (Seattle WA) Hellstrom Karl E. (Seattle WA) Kahn Maria S. (Seattle WA), Tumor immunotherapy using anti-idiotypic antibodies.
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Loria Roger M. (Richmond VA) Regelson William (Richmond VA), Use of DHEA as a medicinal.
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Loria Roger M. (P.O. Box 678 Richmond VA 23298) Regelson William (P.O. Box 678 Richmond VA 23298), Use of dehydroepiandrosterone to improve immune response.
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A	생활필수품
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[미국특허] Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof 원문보기