A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria.
A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria. The release rate is adjusted by utilizing different salt forms of the additive and adjusting the concentration of a urethane pre-polymer.
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What is claimed is: 1. A lubricant composition comprising: a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride, cyclohexanone, and mixtures thereof, a hydrophilic polymer other than an isocyanate-terminated prepolymer, an isocyanate-terminated prep
What is claimed is: 1. A lubricant composition comprising: a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride, cyclohexanone, and mixtures thereof, a hydrophilic polymer other than an isocyanate-terminated prepolymer, an isocyanate-terminated prepolymer and an alkylester of a carboxylic acid selected from the group consisting of ethyl lactate and methylbenzoate. 2. The composition of claim 1 wherein said hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid and polyethylene oxide. 3. The composition of claim 1 wherein said hydrophilic polymer is polyvinylpyrrolidone. 4. The composition of claim 1 wherein said isocyanate-terminated prepolymer is selected from the group consisting of polyoxyethylene-based isocyanate prepolymers, toluene and isophorone diisocyanate-based prepolymers and hexamethylene isocyanate-terminated polyether prepolymer. 5. The composition of claim 1 wherein said solvent is a mixture comprising tetrahydrofuran and cyclohexanone. 6. The composition of claim 1 wherein the alkylester of carboxylic acid is ethyl lactate. 7. The composition of claim 1 wherein said solvent is a mixture comprising tetrahydrofuran and cyclohexanone, and said alkylester of carboxylic acid is ethyl lactate. 8. The composition of claim 7 wherein the hydrophilic polymer is polyvinylpyrrolidone. 9. The lubricant composition of claim 1 wherein the solvent is a mixture of tetrahydrofuran and cyclohexanone, the hydrophilic polymer is polyvinylpyrrolidone, the isocyanate-terminated prepolymer is a TDI--terminated polyether based (PTMEG) prepolymer which is the reaction product of a diisocyanate and a polyalkylene ether glycol, and the alkylester of a carboxylic acid is ethyl lactate. 10. A method for producing a lubricant composition comprising: blending a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride, cyclohexanone, and mixtures thereof, a hydrophilic polymer other than an isocyanate--terminated prepolymer, an isocyanate-terminated prepolymer, and an alkylester of a carboxylic acid selected from the group consisting of ethyl lactate and methylbenzoate. 11. The method of claim 10 wherein said hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid and polyethylene oxide. 12. The method of claim 11 wherein said hydrophilic polymer is polyvinylpyrrolidone. 13. The method of claim 10 wherein said isocyanate-terminated prepolymer is selected from the group consisting of polyoxyethylene-based isocyanate prepolymers, toluene and isophorone diisocyanate-based prepolymers and hexamethylene isocyanate-terminated polyether prepolymer. 14. The method of claim 10 wherein said solvent is a mixture comprising tetrahydrofuran and cyclohexanone. 15. The method of claim 10 wherein the alkylester of carboxylic acid is ethyl lactate. 16. The method of claim 10 wherein said solvent is a mixture comprising tetrahydrofuran and cyclohexanone, and said alkylester of carboxylic acid is ethyl lactate. 17. The method of claim 16 wherein the hydrophilic polymer is polyvinylpyrrolidone. 18. The method of claim 10 wherein the solvent is a mixture of tetrahydrofuran and cyclohexanone, the hydrophilic polymer is polyvinylpyrrolidone, the isocyanate-terminated prepolymer is a TDI--terminated polyether based (PTMEG) prepolymer which is the reaction product of a diisocyanate and a polyalkylene ether glycol, and the alkylester of a carboxylic acid is ethyl lactate. 19. A medical device at least partially coated with a lubricious composition comprising: a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride, cyclohexanone and mixtures thereof, a hydrophilic polymer other than an isocyanate-terminated prepolymer, an isocyanate-terminated prepolymer and an alkylester of a carboxylic acid selected from the group consisting of ethyl lactate and methyl benzoate. 20. The medical device of claim 19 wherein the lubricious composition is further cured. 21. The medical device of claim 19, wherein said medical device is selected from the group consisting of a catheter, an arterial venous shunt, a gastroenteric feed tube and an endotracheal tube. 22. The medical device of claim 19, wherein said medical device is an urological catheter formed of polyvinyl chloride. 23. The medical device of claim 19, wherein said solvent is a mixture of tetrahydrofuran and cyclohexanone, the hydrophilic polymer is polyvinylpyrrolidone, the isocyanate-terminated prepolymer is TDI--terminated polyether based (PTMEG) prepolymer which is the reaction product of a diisocyanate and a polyalkylene ether glycol and the alkylester of a carboxylic acid is ethyl lactate.
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이 특허에 인용된 특허 (10)
Lorenz Donald H. (Basking Ridge NJ) Creasy Walter S. (Bridgewater NJ), Bio-effecting medical material and device.
Hudgin Donald Edward (Princeton Junction NJ) Blair Edgar Allan (Cranbury NJ), Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles.
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