A device for delivery of medicament includes a main housing, a container having at least two compartments, each containing a component of the medicament to be injected, and arranged to be connected to a patient delivery element, a longitudinally movable piston and a spring arrangement acting on the
A device for delivery of medicament includes a main housing, a container having at least two compartments, each containing a component of the medicament to be injected, and arranged to be connected to a patient delivery element, a longitudinally movable piston and a spring arrangement acting on the piston to exert a force on the components, a first holding element for holding the piston in a force-loaded state, and at least one activator for releasing the piston, a second holding element for stopping the piston when it has moved a certain first distance after one activation of the at least one activator and holding the piston in that position, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix.
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The invention claimed is: 1. Device for delivery of medicament comprising a main housing, a container including at least two compartments, wherein each compartment contains a component of the medicament to be injected, and arranged to be connected to a patient delivery means, a longitudinally movab
The invention claimed is: 1. Device for delivery of medicament comprising a main housing, a container including at least two compartments, wherein each compartment contains a component of the medicament to be injected, and arranged to be connected to a patient delivery means, a longitudinally movable piston and a spring arrangement acting on the piston and capable of exerting a force on the components, a first holding means arranged and capable of holding the piston in a force-loaded state, first activator means capable of acting on the first holding means for releasing the piston a certain first distance, wherein the force from the spring arrangement causes the piston to move the first distance, allowing the compartments to communicate with each other and the components to mix, a second holding means capable of stopping the movement of the piston when it has moved the first distance after one activation of the first activator means and holding the piston and the spring arrangement in that position, and dose adjusting means arranged and capable of interacting with the second holding means for adjusting a predetermined dose which corresponds to a second distance to be moved by the piston, wherein a second activator means is capable of acting on the second holding means for further releasing the piston, and wherein, upon a subsequent activation of the first activator means, the force from the spring arrangement causes the piston to move the second distance and eject the predetermined dose through the patient delivery means. 2. Device according to claim 1, wherein the first and second holding means comprise protrusions arranged on said piston and flexible holding members cooperating with said protrusions. 3. Device according to claim 1, wherein the first activator means comprises an activator button which upon being depressed, is capable of releasing the first and second holding means. 4. Device according to claim 2, wherein the dose adjusting means comprises a plurality of protrusions arranged adjacent said piston, where each protrusion is arranged at different axial distance, the piston comprises a ledge capable of cooperating with said plurality of protrusions, and means for aligning a selected one of said plurality of protrusions in the travel path of said piston, thereby defining said second distance. 5. Device according to claim 1, further comprising a needle shield arranged and capable of extending around the needle upon withdrawal of the injector from the injection site, and capable of locking in that extended position. 6. Device for delivery of medicament comprising: a main housing; a container including at least two compartments, wherein each compartment contains a component of the medicament to be injected, and arranged to be connected to a patient delivery means; a longitudinally movable piston and a spring arrangement acting on the piston and capable of exerting a force on said components; a first holding means arranged and capable of holding the piston in a force-loaded state; first activator means capable of acting on the first holding means for releasing the piston, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix; a second holding means capable of stopping the movement of the piston when it has moved a certain first distance after one activation of the first activator means and holding the piston in that position; and dose adjusting means arranged and capable of adjusting a second distance of the piston/spring arrangement in order to set a predetermined dose; wherein a second activator means is capable of acting on the second holding means for releasing the piston; upon a subsequent activation of the first activator means, the piston moves the second distance; the force from the piston/spring arrangement and the movement causes the mixed components to be ejected through the patient delivery means; and the second holding means comprises threads arranged on said piston, a first and a second nut threaded on said piston, and an abutment wall arranged adjacent said piston, against which the nuts abut when the piston has moved the first distance, means for displacing the second of said nuts in relation to the first nut axially along said piston, wherein said second holding means is capable of holding said first nut, and wherein the second activator means comprises a front end of said device capable of being movable axially upon penetration of said device into a patient, which axial movement causes said second holding means to release said first nut and hold said second nut, where the force of the piston/spring arrangement causes the first nut to rotate and the piston to move. 7. Device according to claim 6, wherein the means for displacing said second nut constitutes a dose adjusting means and the axial displacement of said second nut corresponds to said second distance. 8. Device according to claim 6, wherein the dose adjusting means comprises a plurality of protrusions arranged adjacent the piston, where each protrusion is arranged at different axial distance, the piston comprises a ledge capable of cooperating with the plurality of protrusions, and means for aligning a selected one of the plurality of protrusions in the travel path of the piston, thereby defining the second distance. 9. Device according to claim 6, further comprising a needle shield arranged and capable of extending around the needle upon withdrawal of the injector from the injection site, and capable of locking in that extended position.
Sarnoff Stanley J. (Bethesda MD) Tarello William R. (Bethesda MD) Lopez Claudio (Silver Spring MD) Karcher Daniel W. (Great Falls VA), Automatic medicament ingredient mixing and injecting apparatus.
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