Active agent delivery systems and methods for protecting and administering active agents
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/135
A61K-038/05
C07C-229/60
C07C-229/00
C07K-005/06
C07K-005/00
출원번호
US-0923088
(2004-08-23)
등록번호
US-7427600
(2008-09-23)
발명자
/ 주소
Mickle,Travis
Krishnan,Suma
Moncrief,James Scott
Lauderback,Christopher
Piccariello,Thomas
Kirk,Randal
출원인 / 주소
Shire LLC
대리인 / 주소
Darby & Darby, P.C.
인용정보
피인용 횟수 :
21인용 특허 :
60
초록
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.
대표청구항▼
What is claimed is: 1. A method of treating inflammatory bowel disease comprising administering to a patient in need thereof an effective amount of a compound consisting of mesalamine covalently attached to a single amino acid selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine,
What is claimed is: 1. A method of treating inflammatory bowel disease comprising administering to a patient in need thereof an effective amount of a compound consisting of mesalamine covalently attached to a single amino acid selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine, Cysteine, Glutamine, Histidine, Methionine, Phenylalanine, Serine, Threonine, Tryptophan and Tyrosine or a pharmaceutically acceptable salt thereof. 2. A compound consisting of mesalamine covalently attached to a single amino acid wherein said single amino acid is selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine, Cysteine, Glutamine, Histidine, Methionine, Phenylalanine, Serine, Threonine, Tryptophan and Tyrosine or a pharmaceutically acceptable salt thereof. 3. The compound of claim 2, wherein the amino acid is Valine. 4. A pharmaceutical composition comprising: a compound consisting of mesalamine covalently attached to a single amino acid selected from Valine, Alanine, Asparagine, Isoleucine, Proline, Lysine, Cysteine, Glutamine, Histidine, Methionine, Phenylalanine, Serine, Threonine, Tryptophan and Tyrosine or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient. 5. The pharmaceutical composition of claim 4, wherein said composition is an oral dosage form. 6. The pharmaceutical composition of claim 4, wherein the compound is mesalamine covalently attached to Valine. 7. The method of claim 1, wherein the compound is mesalamine covalently attached to Valine.
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