Method for fabricating microneedle array and method for fabricating embossing mold of microneedle array
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B44C-001/22
C25F-003/00
출원번호
US-0691573
(2007-03-27)
등록번호
US-7429333
(2008-09-30)
우선권정보
TW-96100248 A(2007-01-03)
발명자
/ 주소
Chiou,Jin Chern
Hung,Chen Chun
Chang,Chih Wei
출원인 / 주소
National Chiao Tung University
대리인 / 주소
Chow,Ming
인용정보
피인용 횟수 :
16인용 특허 :
5
초록▼
The present invention discloses a method for fast fabricating microneedle arrays with an embossing process and a method for fabricating an embossing mold of a microneedle array, wherein a master pattern of a high aspect ratio silicon microneedle array is fabricated with a microelectromechanical tech
The present invention discloses a method for fast fabricating microneedle arrays with an embossing process and a method for fabricating an embossing mold of a microneedle array, wherein a master pattern of a high aspect ratio silicon microneedle array is fabricated with a microelectromechanical technology, and the master pattern is used to fabricate an embossing mold; a thermosetting material is filled into the embossing mold; then, baking, pressing and mold-stripping are undertaken; thereby, disposable solid polymer microneedle arrays can be batch-fabricated.
대표청구항▼
What is claimed is: 1. A method for fabricating a microneedle array, comprising the following steps: providing a high aspect ratio microneedle array as a master pattern; spin-coating a first plastic material over said master pattern to form an embossing mold; and filling a second plastic material i
What is claimed is: 1. A method for fabricating a microneedle array, comprising the following steps: providing a high aspect ratio microneedle array as a master pattern; spin-coating a first plastic material over said master pattern to form an embossing mold; and filling a second plastic material into said embossing mold, and undertaking baking, pressing, mold-stripping and curing procedures of said second plastic material to obtain a polymer microneedle array; and said second plastic material is PDMS (poly dimethylsiloxane) or PMMA (polymethylmethacrylate). 2. The method for fabricating a microneedle array according to claim 1, wherein the fabrication of said master pattern comprises the following steps: providing a substrate; forming a blocking layer over said substrate; performing an isotropic etching step and an anisotropic etching step sequentially with said blocking layer being mask to obtain a master pattern of a high aspect ratio microneedle array; and removing said blocking layer. 3. The method for fabricating a microneedle array according to claim 1, wherein said microneedle has a height of between 100 and 800 μm and a width of between 10 and 50 μm. 4. The method for fabricating a microneedle array according to claim 1, wherein when said second plastic material is identical to said first plastic material, a parting agent is previously applied to mold cavity of said embossing mold before said second plastic material is filled into said embossing mold. 5. The method for fabricating a microneedle array according to claim 1, wherein said first plastic material is PDMS (poly dimethylsiloxane). 6. The method for fabricating a microneedle array according to claim 2, wherein the material of said substrate is silicon. 7. The method for fabricating a microneedle array according to claim 1, further comprising a step of forming an electrically-conductive layer over said polymer microneedle array. 8. The method for fabricating a microneedle array according to claim 7, wherein said polymer microneedle array with said electrically-conductive layer apply to biomedical field for physiological measurement. 9. The method for fabricating a microneedle array according to claim 1, wherein said polymer microneedle array apply to field of invasive medical processes. 10. The method for fabricating a microneedle array according to claim 1, wherein said polymer microneedle array apply to field of invasive hi-tech personal identification. 11. The method for fabricating a microneedle array according to claim 1, wherein time of said mold-stripping procedure is controlled with temperature. 12. The method for fabricating a microneedle array according to claim 7, wherein material of said electrically-conductive layer is titanium or platinum. 13. The method for fabricating a microneedle array according to claim 2, wherein said blocking layer is removed with a dry etching method or a wet etching method. 14. The method for fabricating a microneedle array according to claim 1, wherein after said first plastic material is spin-coated over said master pattern, a step of removing gas bubbles inside said first plastic material and a step of baking, pressing, mold-stripping and curing said first plastic material in a vacuum state follows. 15. The method for fabricating a microneedle array according to claim 14, wherein said first plastic material is previously heated at a temperature of between 75 and 105�� C. for from 120 to 180 seconds before said first plastic material is spin-coated over said master pattern. 16. The method for fabricating a microneedle array according to claim 1, wherein said baking procedure is undertaken at a temperature of between 230 and 270�� C. for 1 hour. 17. A method for fabricating an embossing mold of a microneedle array, comprising the following steps: providing a high aspect ratio microneedle array as a master pattern; spin-coating a first plastic material over said master pattern to form a first polymer layer; removing gas bubbles inside said first polymer layer; undertaking baking, pressing, mold-stripping and curing procedures of said first polymer layer to obtain an embossing mold of said microneedle array; and filling a second plastic material into said embossing mold and a step of baking, pressing, mold-stripping and curing said second plastic material to obtain a polymer microneedle array, wherein said second plastic material is PDMS (poly dimethylsiloxane) or PMMA (polymethylmethacrylate). 18. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein the fabrication of said master pattern comprises the following steps: providing a substrate; forming a blocking layer over said substrate; performing an isotropic etching step and an anisotropic etching step sequentially with said blocking layer being mask to obtain a master pattern of a high aspect ratio microneedle array; and removing said blocking layer. 19. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein said microneedle has a height of between 100 and 800 μm and a width of between 10 and 50 μm. 20. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein when said second plastic material is identical to said first plastic material, a parting agent is previously applied to mold cavity of said embossing mold before said second plastic material is filled into said embossing mold. 21. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein said first plastic material is PDMS (poly dimethylsiloxane). 22. The method for fabricating an embossing mold of a microneedle array according to claim 17, further comprising a step of forming an electrically-conductive layer over said polymer microneedle array. 23. The method for fabricating an embossing mold of a microneedle array according to claim 22, wherein said polymer microneedle array with said electrically-conductive layer apply to biomedical field for physiological measurement. 24. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein said polymer microneedle array apply to field of invasive medical processes. 25. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein said polymer microneedle array apply to field of invasive hi-tech personal identification. 26. The method for fabricating an embossing mold of a microneedle array according to claim 22, wherein material of said electrically-conductive layer is titanium or platinum. 27. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein said first plastic material is previously heated at a temperature of between 75 and 105�� C. for from 120 to 180 seconds before said first plastic material is spin-coated over said master pattern. 28. The method for fabricating an embossing mold of a microneedle array according to claim 17, wherein said baking procedure is undertaken at a temperature of between 230 and 270�� C. for 1 hour.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (5)
Schmidt, Robert N.; Lisy, Frederick J.; Skebe, Gerard G.; Prince, Troy S., Dry penetrating recording device.
Windmiller, Joshua, Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.