[특허]Beads for capturing target cells from bodily fluid

Beads for capturing target cells from bodily fluid 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-005/00 C12N-011/02 C12N-011/00 C12N-011/08 C12N-011/06 C12Q-001/02
출원번호	US-0021304 (2004-12-23)
등록번호	US-7439062 (2008-10-21)
발명자 / 주소	Bhatt,Ram S. Tsinberg,Pavel
출원인 / 주소	Biocept, Inc.
대리인 / 주소	Cooley Godward Kronish LLP
인용정보	피인용 횟수 : 19 인용 특허 : 16

초록 ▼

Spheroidal beads present an exterior surface of a hydrophilic hydrogel, which is an isocyanate-functional polymer that is polymerized by urethane bonds and cross-linked by urethane and urea bonds. Sequestering agents present at the surface are covalently bound to isocyanate groups or to intermediate linkers that are so bound. These beads allow sequestering agents to retain their native three-dimensional configuration, and as a result of such surface characteristics and hydrophilicity, they achieve highly effective capture of very small subpopulations of rare cells from bodily fluids or the like and very effectively deter nonspecific binding of other biomaterials present in such bodily fluid. They may be all-hydrogel spheroids or hydrogel-coated substrates.

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이 특허에 인용된 특허 (16)

Hammen Richard F. (Missoula MT), Chromatographic material.
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Asgari Morteza ; Blick Mark ; Bresser Joel ; Cubbage Michael Lee ; Prashad Nagindra, Enriching and identifying fetal cells in maternal blood for in situ hybridization on a solid surface.
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Simons Malcolm J. (Glenluce AUX), Fetal cell recovery method.
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Calenoff Emanuel (San Francisco CA), Fetal cell separation and testing.
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Hartdegen ; Frank Joseph ; Swann ; Wayne Elliott, Immobilization of proteins with polyurethane polymers.
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Mueller Utz W. (Torens Park AUX) Hawes Catherine S. (Fullarton AUX), Isolation of fetal cells from maternal blood to enable prenatal diagnosis.
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Matthews Virgil Edison (Charleston WV) Knopf Robert John (Saint Albans WV), Lightly cross-linked polyurethane hydrogels based on poly(alkylene ether) polyols.
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Biebricher Christof (Adelebsen DEX) Luce Rudiger (Herzberg DEX), Method for the production of a vehicle substance which is capable of covalent bonding with biologically active matter.
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Guire Patrick (Eden Prarie MN) Dunkirk Shawn G. (Eden Prarie MN), Method of biomolecule attachment to hydrophobic surfaces.
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Berenson Ronald J. (Mercer Island WA) Peterson Dale R. (Bothell WA), Methods for removing ligands from a particle surface.
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Bianchi Diana W. (Brookline MA), Non-invasive method for isolation and detection of fetal DNA.
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Bianchi Diana W., Prenatal diagnosis by isolation of fetal granulocytes from maternal blood.
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Burchell Ann,GBX ; Hume Robert,GBX, Prenatal diagnostic methods.
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Datar Rajiv V., Procedures for efficient separation of cells, cellular materials and proteins.
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Stipanovic, Bozidar; Griffin, Martin; Scarpa, Ioannis, Simulated activity of Protein A displayed by ligands attached to a cellulose bead surface.
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Vandegaer ; Jan E. ; Calentine ; John W., Stable polyurethane latices, emulsifiable prepolymers therefor and methods of making the same.
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이 특허를 인용한 특허 (19)

Wilson, Jeffrey A.; Milbocker, Michael, Apparatus and method for limiting surgical adhesions.
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Handique, Kalyan; Gogoi, Priyadarshini; Siemer, Christopher; Javdani, Saedeh Sepehri, Cell capture system and method of use.
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Handique, Kalyan; Gogoi, Priyadarshini; Siemer, Christopher; Javdani, Saedeh Sepehri, Cell capture system and method of use.
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Handique, Kalyan; Gogoi, Priyadarshini; Siemer, Christopher; Javdani, Saedeh Sepehri, Cell capture system and method of use.
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Parikh, Bhairavi; Brody, Michael D.; Stone, James; Halderman, Jonathan D., Method and device for identification of nucleated red blood cells from a maternal blood sample.
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Parikh, Bhairavi; Brody, Michael D.; Stone, James; Halderman, Jonathan D., Method and device for identification of nucleated red blood cells from a maternal blood sample.
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Allman, Richard; Mantzaris, Debbie; Vom, Eduardo; Lewis, Craig Matthew, Methods for obtaining fetal genetic material.
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Smiecinski, Theodore M., Single layer flexible foam including polyurethane gel.
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Handique, Kalyan; Gleason, Kyle; Payne, Austin; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Siemer, Christopher; Zhou, Yi, System and method for capturing and analyzing cells.
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Handique, Kalyan; Gleason, Kyle; Payne, Austin; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Siemer, Christopher; Zhou, Yi, System and method for capturing and analyzing cells.
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Handique, Kalyan; Gleason, Kyle; Payne, Austin; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Siemer, Christopher; Zhou, Yi, System and method for capturing and analyzing cells.
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Handique, Kalyan; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Zhou, Yi, System and method for capturing and analyzing cells.
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Handique, Kalyan; Gogoi, Priyadarshini; Zhou, Yi; Javdani, Saedeh Sepehri, System and method for capturing and analyzing cells.
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Handique, Kalyan; Gleason, Kyle; Payne, Austin; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Siemer, Christopher; Zhou, Yi, System for capturing and analyzing cells.
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Handique, Kalyan; Gleason, Kyle; Payne, Austin; Gogoi, Priyadarshini; Siemer, Christopher; Zhou, Yi; Sepehri, Saedeh Javdani, System for capturing and analyzing cells.
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Handique, Kalyan; Gleason, Kyle; Payne, Austin; Gogoi, Priyadarshini; Siemer, Christopher; Zhou, Yi; Sepehri, Saedeh Javdani, System for capturing and analyzing cells.
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Handique, Kalyan; Gleason, Kyle; Siemer, Christopher; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Parunak, Gene; Kehrer, Aaron; Meines, Jon, System for imaging captured cells.
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Handique, Kalyan; Gleason, Kyle; Siemer, Christopher; Gogoi, Priyadarshini; Javdani, Saedeh Sepehri; Parunak, Gene; Kehrer, Aaron; Meines, Jon, System for imaging captured cells.
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Handique, Kalyan; Gogoi, Priyadarshini; Zhou, Yi; Sepehri, Saedeh; Siemer, Christopher, System for isolating cells.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Beads for capturing target cells from bodily fluid 원문보기