Synergistic antioxidant combination of delta tocols and polyphenols
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-047/00
C11B-005/00
출원번호
US-0399339
(2001-10-22)
등록번호
US-7452549
(2008-11-18)
국제출원번호
PCT/EP01/012188
(2001-10-22)
§371/§102 date
20030724
(20030724)
국제공개번호
WO02/034072
(2002-05-02)
발명자
/ 주소
Hasler Nguyen,Nathalie
Zijlstra,Jacob
Troup,John P.
출원인 / 주소
Nestec S.A.
대리인 / 주소
Lobel,Gary M.
인용정보
피인용 횟수 :
7인용 특허 :
7
초록▼
A source of δ-tocotrienol and/or-tocopherol acts synergistically with an antioxidant source comprising polyphenols, to effect suppression of LDL oxidation in serum. The combination of these two antioxidant sources has wide-ranging applications in treatment of medical conditions arising from fre
A source of δ-tocotrienol and/or-tocopherol acts synergistically with an antioxidant source comprising polyphenols, to effect suppression of LDL oxidation in serum. The combination of these two antioxidant sources has wide-ranging applications in treatment of medical conditions arising from free radical generation, including arteriosclerosis and cancer.
대표청구항▼
The invention claimed is: 1. A composition comprising: (a) a source of δ-tocol comprising greater than 2% by weight said δ-tocol; and (b) polyphenols, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ
The invention claimed is: 1. A composition comprising: (a) a source of δ-tocol comprising greater than 2% by weight said δ-tocol; and (b) polyphenols, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ-tocopherol when said polyphenols comprises citrus flavonoids, and wherein said composition is substantially free of α-tocopherol. 2. A composition according to claim 1, which in a unit dosage comprises 0.5 to 50 mg δ-tocol. 3. A composition comprising in a daily dosage: (a) at least 5 mg δ-tocol selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof; and (b) polyphenols, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1 , and wherein said composition is substantially free of α-tocopherol. 4. A composition comprising in a daily dosage: (a) at least 5 mg of δ-tocol selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof; and (b) polyphenols other than citrus flavonoids, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and wherein said composition is substantially free of α-tocopherol. 5. The composition according to claim 1, further comprising a catechin. 6. The composition according to claim 1, further comprising α-tocopherol, wherein a weight ratio of δ-tocol to α-tocopherol is greater than 0.65. 7. The composition according to claim 1, wherein δ-tocol is a Tocotrienol Rich Fraction (TRF) source selected from the group consisting of palm oil or rice bran oil and a blend of tocopherols, and said polyphenols is selected from the group consisting of green tea, Pu Erh tea, extracts thereof and mixtures thereof. 8. The composition according to claim 1, which is substantially free of tocols other than δ-tocols. 9. The composition according to claim 1, wherein an antioxidant property of the composition is greater in the case that said polyphenols consist of a single polyphenolic antioxidant source than in the case that said polyphenols include more than one polyphenolic antioxidant source. 10. The composition according to claim 1, further comprising a nutritionally quantity of a carbohydrate, a fat, a fiber or a protein. 11. The composition according to claim 1, further a pharmaceutically acceptable carrier. 12. The composition according to claim 11, further comprising antioxidants consisting essentially of said δ-tocol and said polyphenols. 13. A kit comprising: (a) a source of δ-tocol preferably comprising greater than 2% by weight δ-tocol; and (b) an antioxidant source comprising polyphenols, for separate, sequential or simultaneous administration, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, wherein said δ-tocol is selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof, and wherein said kit is substantially free of α-tocopherol. 14. The composition according to claim 1, further a cosmetically acceptable carrier. 15. A method of treating a medical condition caused by the generation of free radicals comprising the step of administering to a person in need of such treatment an effective amount of a source of δ-tocol comprising greater than 2% by weight said δ-tocol and polyphenols, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ-tocopherol when said polyphenols comprises citrus flavonoids, and wherein administration is substantially free of α-tocopherol. 16. The method of claim 15, wherein said medical condition is selected from the group consisting of arteriosclerosis, rheumatism and cancer. 17. The method of claim 15, wherein said medical condition is caused by physical activity, sun exposure or smoking. 18. A method of preventing spoilage in a food or beverage product comprising the step of using a composition comprising a source of δ-tocol preferably comprising greater than 2% by weight δ-tocol and an antioxidant source comprising polyphenols as a preservative wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, wherein said δ-tocol is selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof, and wherein said composition is substantially free of α-tocopherol.
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