[특허]Controlled release device and method using electrothermal ablation

MicroCHIPS, Inc.

검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
검색연산자

검색도움말
검색연산자	기능	검색시 예
()	우선순위가 가장 높은 연산자	예1) (나노 (기계 \| machine))
공백	두 개의 검색어(식)을 모두 포함하고 있는 문서 검색	예1) (나노 기계) 예2) 나노 장영실
\|	두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색	예1) (줄기세포 \| 면역) 예2) 줄기세포 \| 장영실
!	NOT 이후에 있는 검색어가 포함된 문서는 제외	예1) (황금 !백금) 예2) !image
*	검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색	예) semi*
""	따옴표 내의 구문과 완전히 일치하는 문서만 검색	예) "Transform and Quantization"

과학기술 지식인프라 ScienceON

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

특허 상세정보

MyON담기

내보내기 페이스북 공유 트위터 공유 카카오톡 공유

Controlled release device and method using electrothermal ablation

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/22
미국특허분류(USC)	604/890.1; 604/500
출원번호	US-0259301 (2005-10-26)
등록번호	US-7455667 (2008-11-25)
발명자 / 주소	Uhland,Scott A. Polito,Benjamin F. Maloney,John M. Sheppard, Jr.,Norman F. Herman,Stephen J. Yomtov,Barry Y.
출원인 / 주소	MicroCHIPS, Inc.
대리인 / 주소	Sutherland Asbill & Brennan LLP
인용정보	피인용 횟수 : 29 인용 특허 : 90

초록
▼

Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

대표
청구항
▼

We claim: 1. A method for the controlled delivery of molecules comprising: positioning at a preselected location a device which includes a substrate having at least one discrete reservoir in which the molecules for delivery are stored, and a discrete reservoir cap in register with an opening in the reservoir and formed of an electrically conductive material which prevents said molecules for delivery from passing out from the device; and applying an electrical current through said reservoir cap, via an electrical input lead and an electrical output lead which are electrically connected to and directly contact said reservoir cap, to rupture the reservoir cap and not the substrate to enable the molecules to pass outward from the device to the preselected location. 2. The method of claim 1, wherein the device is an implantable medical device. 3. The method of claim 2, wherein the molecules for delivery comprise drug molecules. 4. The method of claim 3, wherein the drug molecules comprise a human parathyroid hormone. 5. The method of claim 2, wherein the molecules for delivery comprise a therapeutic or prophylactic agent and the preselected location comprises an intrathecal, intracranial, abdominal/peritoneal, thoracic, intrapericardial, renal, or hepatic space. 6. The method of claim 5, wherein the drug molecules comprise human parathyroid hormone hPTH(1-34). 7. The method of claim 1, wherein the reservoir caps comprise at least one metal film. 8. The method of claim 7, wherein the reservoir caps comprise titanium, platinum, gold, or a combination thereof. 9. The method of claim 1, wherein the substrate comprises silicon. 10. The method of claim 1, wherein the application of electrical current through the reservoir cap causes the temperature of the reservoir cap to increase preferentially compared to the temperature of the leads. 11. The method of claim 1, wherein the reservoir cap is formed of a material having a melting point which differs from the melting point of the material forming the leads. 12. The method of claim 1, wherein the reservoir cap has a smaller cross-sectional area in the direction of electric current flow than that of the leads. 13. The method of claim 1, wherein the leads and the reservoir cap have substantially the same thickness, and the ratio of the width of the leads to the width of the reservoir cap is 2:1 or more. 14. The method of claim 1, wherein the reservoir cap comprises multiple layers of metal or multiple layers of metal and semiconductor. 15. The method of claim 1, further comprising detecting an open electrical circuit between the leads of a reservoir cap that has been ruptured, to verify reservoir opening. 16. The method of claim 1, wherein the drug molecules comprise parathyroid hormone. 17. A method for the controlled delivery of molecules comprising: positioning at a preselected location a device which comprises a substrate, a plurality of discrete reservoirs disposed in the substrate, reservoir contents which comprise the molecules for delivery located in said plurality of reservoirs, an electrically conductive, discrete reservoir cap covering an opening in each reservoir, a conducting input lead and a conducting output lead each of which are electrically connected to and directly contact each reservoir cap, and a source of electric power; and then applying an electrical current from the power source through said reservoir cap, via the conducting leads, to rupture the reservoir cap by electrothermal ablation and not rupture the substrate, thereby enabling the molecules to pass outward from the device to the preselected location. 18. The method of claim 17, wherein the device is an implantable medical device. 19. The method of claim 18, wherein the molecules for delivery comprise drug molecules. 20. The method of claim 19, wherein the drug molecules comprise a human parathyroid hormone. 21. The method of claim 18, wherein the molecules for delivery comprise a therapeutic or prophylactic agent, and the preselected location comprises an intrathecal, intracranial, abdominal/peritoneal, thoracic, intrapericardial, renal, or hepatic space. 22. The method of claim 21, wherein the drug molecules comprise human parathyroid hormone hPTH(1-34). 23. The method of claim 17, wherein the reservoir caps comprise at least one metal film. 24. The method of claim 23, wherein the reservoir caps comprise titanium, platinum, gold, or a combination thereof. 25. The method of claim 23, wherein the substrate comprises silicon. 26. The method of claim 17, wherein the reservoirs are microreservoirs. 27. The method of claim 17, wherein the drug molecules comprise parathyroid hormone. 28. A method for the controlled exposure of reservoir contents comprising: positioning at a preselected location a device which includes a substrate having at least one discrete reservoir in which the reservoir contents for exposure are disposed, and a discrete reservoir cap in register with the at least one reservoir and formed of an electrically conductive material which prevents exposure of said reservoir contents to molecules outside of the device; and applying an electrical current through said reservoir cap, via an electrical input lead and an electrical output lead which are electrically connected to and directly contact said reservoir cap, to rupture the reservoir cap and not the substrate to expose the reservoir contents to said molecules at the preselected location. 29. The method of claim 28, wherein the device is an implantable medical device. 30. The method of claim 29, wherein the reservoir contents comprises a sensor or sensor component. 31. The method of claim 30, wherein the sensor or sensor component can detect in a patient in vivo glucose, urea, calcium, or a hormone. 32. The method of claim 29, wherein the preselected location comprises an intrathecal, intracranial, abdominal/peritoneal, thoracic, intrapericardial, renal, or hepatic space. 33. The method of claim 28, wherein the reservoir cap comprises at least one metal film. 34. The method of claim 33, wherein the reservoir cap comprises titanium, platinum, gold, or a combination thereof. 35. The method of claim 28, wherein the substrate comprises silicon. 36. The method of claim 28, wherein the application of electrical current through the reservoir cap causes the temperature of the reservoir cap to increase preferentially compared to the temperature of the leads. 37. The method of claim 28, wherein the reservoir cap is formed of a material having a melting point which differs from the melting point of the material forming the leads. 38. The method of claim 28, wherein the reservoir cap has a smaller cross-sectional area in the direction of electric current flow than that of the leads. 39. The method of claim 28, wherein the leads and the reservoir cap have substantially the same thickness, and the ratio of the width of the leads to the width of the reservoir cap is 2:1 or more. 40. The method of claim 28, wherein the reservoir cap comprises multiple layers of metal or multiple layers of metal and semiconductor. 41. The method of claim 28, further comprising detecting an open electrical circuit between the leads of a reservoir cap that has been ruptured, to verify reservoir opening. 42. A method for the controlled exposure of reservoir contents comprising: positioning at a preselected location a device which comprises a substrate, a plurality of reservoirs disposed in the substrate, reservoir contents which comprise a secondary device located in said plurality of reservoirs, an electrically conductive, discrete reservoir cap covering an opening in each reservoir, a conducting input lead and a conducting output lead each of which are electrically connected to and directly contact each reservoir cap, and a source of electric power; and then applying an electrical current from the power source through said reservoir cap, via the electrical input lead and the electrical output leads, to rupture the reservoir cap by electrothermal ablation and not rupture the substrate, thereby exposing the secondary device to molecules at the preselected location. 43. The method of claim 42, wherein the device is an implantable medical device. 44. The method of claim 43, wherein the secondary device comprises a sensor or sensor component. 45. The method of claim 44, wherein the sensor or sensor component can detect in a patient in vivo glucose, urea, calcium, or a hormone. 46. The method of claim 43, wherein the preselected location comprises an intrathecal, intracranial, abdominal/peritoneal, thoracic, intrapericardial, renal, or hepatic space. 47. The method of claim 42, wherein the reservoirs are microreservoirs. 48. A method for the controlled exposure of a sensor comprising: providing a device which includes at least one reservoir provided in a substrate, at least one sensor located in the at least one reservoir, at least one reservoir cap, which comprises a metal, closing off at least one opening in each reservoir to seal the at least one sensor within the reservoir, an electrical input lead and an electrical output lead which are electrically connected to and directly contact the reservoir cap, and a source of electric power; and applying an electrical current from the power source through the at least one reservoir cap, via said pair of conductive leads, in an amount effective to rupture the reservoir cap by electrothermal ablation and not rupture the substrate, thereby exposing the at least one sensor. 49. The method of claim 48, wherein the device is implanted into a patient and the sensor detect a physiological condition in the patient. 50. The method of claim 48, wherein the sensor is a biosensor which detects an analyte in the patient. 51. The method of claim 50, wherein the analyte comprises glucose, urea, calcium, or a hormone.

이 특허에 인용된 특허 (90)

이 특허를 인용한 특허 피인용횟수: 29

IPC 상위 출원인

내보내기

상세정보
내보내기 구분	파일저장 인쇄 메일전송
구성항목	관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	> 총 건의 자료가 검색되었습니다. > 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) > 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. > 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) > 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오 > ~ > Text(ASCII format) Excel format

과학기술 지식인프라 ScienceON

ScienceON Chatbot

연합인증

특허 상세정보

Controlled release device and method using electrothermal ablation

초록
▼

대표
청구항
▼

이 특허에 인용된 특허 (90)

이 특허를 인용한 특허 피인용횟수: 29

IPC 상위 출원인

과제정보

상세정보조회

원문조회

IPC 상세정보(version : 201201)

연구과제 성과물(0)

참여연구원의 다른 문헌(0)

처리중입니다.

잠시만 기다려주세요.

ScienceON Chatbot

연합인증

특허 상세정보

Controlled release device and method using electrothermal ablation

초록 ▼

대표청구항 ▼

이 특허에 인용된 특허 (90)

이 특허를 인용한 특허 피인용횟수: 29

IPC 상위 출원인

과제정보

상세정보조회

원문조회

IPC 상세정보(version : 201201)

연구과제 성과물(0)

참여연구원의 다른 문헌(0)

처리중입니다.

잠시만 기다려주세요.

초록
▼

대표
청구항
▼