[특허]Drug delivery particle

[미국특허] Drug delivery particle 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/14 A61K-009/50
출원번호	US-0232265 (2002-08-30)
등록번호	US-7462366 (2008-12-09)
발명자 / 주소	Lanphere,Janel L. McKenna,Erin P. Naimark,Wendy Buiser,Marcia S. Mangin,Stephan P.
출원인 / 주소	Boston Scientific Scimed, Inc.
대리인 / 주소	Fish & Richardson P.C.
인용정보	피인용 횟수 : 42 인용 특허 : 302

초록

A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.

대표청구항 ▼

What is claimed is: 1. A drug delivery device comprising: a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, wherein the second predominant pore size is from about 50% to about 70% of the first predominant pore size. 2. The device of claim 1 wherein the polyvinyl alcohol is 1,3 diol acetalized. 3. The device of claim 1 wherein the polyvinyl alcohol is modified by graft polymerization. 4. The device of claim 2 wherein the particle further comprises alginate. 5. The device of claim 1 including a coating of polymer. 6. The device of claim 5 wherein the coating is erodable. 7. The device of claim 5 including a therapeutic agent on the surface of the particle. 8. The device of claim 1 wherein the therapeutic agent is effective for the treatment of cancer. 9. The device of claim 1 wherein the particle has a sphericity of about 80% or more. 10. The device of claim 1 wherein the particle has a diameter of about 1 cm or less. 11. The device of claim 1 comprising a collection of particles. 12. A method of manufacturing a drug delivery particle, the method comprising: generating drops comprising polyvinyl alcohol and alginate; forming the drops into particles; and combining the particles with a therapeutic agent, wherein each of the particles is a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size. 13. The method of claim 12, wherein the particles comprise alginate and the method further comprises reacting the polyvinyl alcohol with a cross-linking agent and removing the alginate. 14. The method of claim 13 comprising drying the particle and exposing the dried particle to therapeutic agent. 15. The method of claim 12 comprising combining therapeutic agent prior to generating said drops. 16. The method of claim 12 comprising contacting the drops with a gelling agent. 17. The method of claim 16 wherein the gelling agent is a divalent agent. 18. The method of claim 12, wherein the particles comprise alginate and the method further comprises reacting the polyvinyl alcohol by acetalization. 19. The method of claim 12 wherein the polyvinyl alcohol has a molecular weight of about 75,000 g/mole or greater. 20. The method of claim 12 comprising modifying the viscosity of the polyvinyl alcohol and alginate prior to forming said drops. 21. The method of claim 20 comprising modifying the viscosity by heating. 22. The method of claim 12 comprising forming said drops by vibratory nebulization. 23. The method of claim 12 wherein the therapeutic agent is an anti-cancer agent. 24. A method of delivering a substantially spherical particle to a patient, the method comprising administering to a patient the substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size. 25. The delivery method of claim 24 wherein the method of administration is by percutaneous injection. 26. The delivery method of claim 24 wherein the method of administration is by a catheter. 27. The delivery method of claim 24 wherein the therapeutic agent is effective for treatment of uterine fibroids. 28. The delivery method of claim 24 wherein the therapeutic agent is effective for treatment of cancerous lesions. 29. The delivery method of claim 27, wherein the method is used to treat uterine fibroids. 30. The delivery method of claim 28 wherein the method is used to treat a cancerous legion. 31. A method of delivering a therapeutic agent to a patient, the method comprising: administering to a patient a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size; and releasing the therapeutic agent in the patient.

이 특허에 인용된 특허 (302) 인용/피인용 타임라인 분석

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Wallace George ; Greff Richard J., Methods for treating urinary incontinence in mammals.
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Garibaldi Jeffrey M. ; Hogg Bevil J. ; Hastings Roger N. ; Ren Brooke, Methods of and compositions for treating vascular defects.
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Jeffrey M. Garibaldi ; Bevil J. Hogg ; Roger N. Hastings ; Brooke Ren, Methods of and compositions for treating vascular defects.
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Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Methods of preparing gas and gaseous precursor-filled microspheres.
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Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Methods of preparing gas-filled liposomes.
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Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Methods of preparing gas-filled liposomes.
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Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Methods of preparing gas-filled liposomes.
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Li Nai-Hong,CAX ; Benson James R. ; Kitagawa Naotaka, Methods of preparing polymeric microbeds.
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Rasor Julia S. (Cupertino CA) Tickner Ernest G. (Gilroy CA), Microbubble precursors and apparatus for their production and use.
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Rasor Julia S. (Cupertino CA) Tickner Ernest G. (Gilroy CA), Microbubble precursors and methods for their production and use.
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Klaveness Jo,NOX ; Rongved Pal,NOX ; Johansen John Henrik,NOX ; Foss Per Antonius,NOX ; H.o slashed.gset Anders,NOX ; Hvoslef Anne Marie,NOX, Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells.
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Klaveness Jo (Oslo NLX) Rongved Pal (Hellvik NLX) Stubberud Lars (Sodertalje NLX), Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging.
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Stewart Ray F. (Redwood City CA) Greene Lawrence C. (Boulder Creek CA) Bhaskar Ravi K. (Lawrence KS), Microcapsule having temperature-dependent permeability profile.
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Morrison Dennis R. ; Mosier Benjamin, Microcapsules and methods for making.
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Shinozaki Atushi (Okayama JPX) Abe Kunio (Kurashiki JPX), Microorganism immobilized in a gel prepared from polyvinyl alcohol and a polysaccharide.
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Akagi Yasaburo,JPX ; Takechi Nobuyuki,JPX ; Nonomura Muneo,JPX, Microparticle preparation and production thereof.
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Steiner Solomon S. ; Feldstein Robert ; Lian Huiling ; Rhodes Christopher A. ; Shen Gregory S., Microparticles for lung delivery comprising diketopiperazine.
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Klaveness Jo,NOX ; Rongved Pal,NOX ; Stubberud Lars,SEX, Microparticulate microbubble-generating contrast agents.
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Goldberg Eugene P. (Gainesville FL) Longo William E. (Gainesville FL) Iwata Hiroo (Suita JPX), Microspheres for incorporation of therapeutic substances and methods of preparation thereof.
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Day Delbert E. (Rolla MO) Ehrhardt Gary J. (Columbia MO), Microspheres for radiation therapy.
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Batich, Christopher D.; Leckey, Adam; Vauthey, J. Nicolas, Microspheres for use in the treatment of cancer.
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Boschetti Egisto (Croissy-sur-Seine FRX) Brouard Michel (Belloy-en-France FRX) Drouet Ludovic (Bourg-la-Reine FRX) Girot Pierre (Paris FRX) Laurent Alexandre (Courbevoie FRX) Wassef Michel (Paris FRX, Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same.
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Boschetti Egisto (Croissy-sur-Seine FRX) Brouard Michel (Belloy-en-France FRX) Drouet Ludovic (Bourg-la-Reine FRX) Girot Pierre (Paris FRX) Laurent Alexandre (Courbevoie FRX) Wassef Michel (Paris FRX, Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same.
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Lee Chul-Joo,KRX ; Lyoo Won-Seok,KRX ; Kwon Ick-Chan,KRX ; Lee Se-Geun,KRX ; Kim Jae-Pil,KRX ; Han Moon-Hee,KRX, Microspheric embolic materials having a dual structure of poly(vinyl acetate) core and poly(vinyl alcohol) shell and method for preparing the same.
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Kriesel Marshall S. ; Thompson Thomas N., Mixing and delivery syringe assembly.
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Kriesel Marshall S. ; Thompson Thomas N., Mixing and delivery syringe assembly.
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White James L. (Maplewood MN) Berg James G. (North St. Paul MN), Mixture of rough and spheroidized resin particles.
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Haerr Raymond H. (Cincinnati OH), Moisture-expandable ear wick.
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Haerr Raymond H. (Cincinnati OH), Moisture-expandable prosthesis.
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Hench Larry L.,GBX ; LaTorre Guy ; West Jon K. ; Wilson June,GBX ; Toreki ; III William ; Batich Christopher, Moldable bioactive compositions.
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Zion Earl M. (Newark OH), Molded composite article and method for making the article.
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Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chung Sang-Kun (Diamond Bar CA) Colvin Michael S. (Malibu CA) Chang Manchium (Los Angeles CA), Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops.
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Morishita Takashi (Nishinomiya JPX) Hata Takehisa (Muko JPX) Mori Mitio (Higashiosaka JPX) Tanoue Shohachi (Toyonaka JPX), Multiple soft capsules and production thereof.
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Pallado Paolo,ITX ; Benedetti Luca,ITX ; Callegaro Lanfranco,ITX, Nanosheres comprising a biocompatible polysaccharide.
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Franses Elias I. (3732 Capilano Dr. West Lafayette IN 47906) Caruthers James M. (1210 Western West Lafayette IN 47906) Keville Kathleen M. (1155 Anthrop Dr. #3 West Lafayette IN 47906), Nonspherical microparticles and method therefor.
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Zadno-Azizi Gholam-Reza ; Bagaoisan Celso J. ; Patel Mukund R. ; Muni Ketan P., Occlusion of a vessel.
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Leibitzki Harry,DEX ; Menz Marina,DEX ; Neubauer Norbert,DEX ; Vogt Sebastian,DEX ; Wienzek Gerhard,DEX, One-piece dispensing device for the contamination-free administration of medicaments (cytostatica).
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Gray Bruce Nathaniel,AUX, Particulate material.
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Annonier Claude,FRX ; Autant Pierre,FRX ; Ruel Jacques,FRX ; Porte Hugues,FRX ; Laffay Jean-Claude,FRX ; Sabatier Alain,FRX, Pellets containing active ingredients protected against degradation in the rumen of ruminants.
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Porter Thomas R. (Omaha NE), Perfluorobutane ultrasound contrast agent and methods for its manufacture and use.
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Porter Thomas R. (Omaha NE), Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide.
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Newton John M. (London GB2) Devereux Jane E. (London GB2), Pharmaceutical formulations.
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Pasztor Emil (4 Rakoczi-u Budapest HUX 1072) Lazar Laszlo (4 ; Rozsahegy-u Budapest HUX 1024) Nagy Jozsef (46/b ; Trbalinti-u Budapest HUX 1122) Pallosy nee Becker Katalin (31 ; Vinceller-u ; Budapes, Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
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Pasztor, Emil; Lazar, Laszlo; Nagy, Jozsef; Pallosy nee Becker, Katalin, Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
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Psztor Emil (4 ; Rkczi-u Budapest HUX 1072) Lzr Lszl (4 ; Rzsahegy-u Budapest HUX 1024) Nagy Jzsef (46/b Trkblinti-u Budapest HUX 1122) Pllosy ne Becker Katalin (31 ; Vincellr-u Budapest HUX 1113), Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization.
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Zimmermann, Wolfgang; Harreus, Albrecht, Plasticizer-containing polyvinyl alcohol granules.
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Rembaum Alan (Pasadena CA), Polyacrolein microspheres.
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Rembaum Alan (Pasadena CA), Polyacrolein microspheres.
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Rembaum Alan (Pasadena CA), Polyacrolein microspheres.
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Salome Frederik (New South Wales AUX) Elliott William T. (New South Wales AUX), Polymer aggregates.
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Wallace Michael P. ; Hui Delilah Yin, Polymer covered vaso-occlusive devices and methods of producing such devices.
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Yamashita Hiroshi (Numazu JPX) Kawase Hiromitsu (Mishima JPX) Shiraishi Keiko (Susono JPX), Polymer particles and toner for electrophotography using the polymer particles.
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Brocchini Stephen ; Hanson Stephen R. ; Kohn Joachim B., Polymeric drug formulations.
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Li Nai-Hong,CAX ; Benson James R. ; Kitagawa Naotaka, Polymeric microbeads.
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Li Nai-Hong (Edmonton CAX) Benson James R. (Los Gatos CA), Polymeric microbeads and method of preparation.
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Li Nai-Hong (Edmonton CAX) Benson James R. (Los Gatos CA) Kitagawa Naotaka (Fremont CA), Polymeric microbeads and method of preparation.
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Li Nai-Hong,CAX ; Benson James R. ; Kitagawa Naotaka, Polymeric microbeads and methods of preparation.
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Buscemi Paul J. (Long Lake MN) Buirge Andrew W. (Minneapolis MN) Bilge Fertac (Arden Hills MN), Polymerization angioplasty balloon implant device.
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Leifholtz Paul J. (Bensalem PA) Meteyer Thomas E. (Gwynedd Valley PA), Polymerization process for making porous polymeric particles.
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Freeman Clarence S. ; Freeman Matthew Max ; Freeman Jon Joseph, Polymerization process with spraying step.
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Fujii Hiroaki,JPX ; Abe Masanobu,JPX ; Oka Keiko,JPX, Polyvinyl alcohol hydrogel and process for producing the same.
상세보기
Hyon Suong-Hyu (Tamatsukurimotomachi JPX) Ikada Yoshito (Tamatsukurimotomachi JPX), Porous and transparent poly(vinyl alcohol) gel and method of manufacturing the same.
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Demopolis Tom N. (Midland MI), Porous copolymers having a cellular polymeric structure suitable for preparing ion-exchange resins and adsorbents.
상세보기
Itagaki Takaharu (Yokohama JPX) Kusano Hiroshi (Yokohama JPX) Miyata Eiji (Kitakyushu JPX) Tashiro Takayuki (Machida JPX), Porous cross-linked polyvinyl alcohol particles, process for producing the same, and separating agent composed of the sa.
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Glajch Joseph L. (Nashua NH) Loomis Gary L. (Drexel Hill PA) Mahler Walter (Wilmington DE), Porous inorganic ultrasound contrast agents.
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Blankenship, Robert Mitchell, Porous particles, their aqueous dispersions, and method of preparation.
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Tani Sumio (Neyagawa JPX) Kogoh Kazuhiko (Osaka JPX) Nozaki Yuri (Kurashiki JPX) Oshima Kunihiro (Osaka JPX), Porous polymer particles and preparation method thereof.
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Feibush Binyamin (State College PA) Li Nai-Hong (Baltimore MD), Porous rigid resins and process of preparation.
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Feibush Binyamin (State College PA) Li Nai-Hong (Baltimore MD), Porous rigid resins and process of preparation.
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Gross James R. (Appleton WI), Porous structure of an absorbent polymer.
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Li Nai-Hong (Edmonton MD CAX) Leong Kam W. (Ellicott City MD), Porous, polymer beads and process of their preparation.
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Lamborne Andrew N. ; de Juan ; Jr. Eugene, Pre-filled package containing unit dose of medical gas and method of making same.
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Grabenkort Richard E., Pre-filled syringe drug delivery system.
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O\Neil John A. (Mundelein IL) Hofstetter John M. (Vernon Hills IL), Prefilled, two-constituent syringe.
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Andrew Derek Sutton GB; Richard Alan Johnson GB, Preparation of diagnostic agents by spray drying.
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Sutton Andrew Derek,GBX ; Johnson Richard Alan,GBX, Preparation of further diagnostic agents.
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Sutton Andrew Derek,GBX ; Johnson Richard Alan,GBX, Preparation of further diagnostic agents.
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Berg Eric P. (Plymouth MN), Preparation of injectable polymeric bodies.
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Vanderhoff John W. (Bethlehem PA) Micale Fortunato J. (Bethlehem PA) El-Aasser Mohamed S. (Bethlehem PA) Tseng Chi-Ming (Bethlehem PA), Preparation of large particle size monodisperse latexes.
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Illum Lisbeth (The Park GBX) Johnson Olufunmiloyo Lilly (Cambridge MA), Preparation of microparticles.
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Forgensi ; Rudolph ; Hagenbach ; Robert J., Preparation of spheroidized particles.
상세보기
Timm Edward E. (Coleman MI), Process and apparatus for preparing uniform size polymer beads.
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Faccioli Giovanni (Montova ITX) Soffiatti Renzo (Verona ITX), Process and apparatus for the mixing and direct emplacement of a two-component bone cement.
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Gross James R. (Appleton WI), Process for forming a porous particle of an absorbent polymer.
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Frazza Mark S. (Philadelphia PA) Ho Kim S. (Richboro PA) Kowalski Alexander (Plymouth Meeting PA) Raney Robert R. (Newtown Square PA) Vogel Martin (Jenkintown PA), Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range.
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Masamizu Koji (Houya JPX) Hirokawa Shinya (Chiba JPX) Fujita Sanae (Tokyo JPX), Process for manufacturing porous polymer.
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Schneider Hans P. (Stade DEX) Grlach-Doht Yvonne M. (Stade DEX) Kmin Marius A. M. (Cham CHX), Process for preparing absorptive porous resin beads.
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Chiou Shang-Jaw (Lower Gwynedd PA) Sheng Miao-Hsun L. (Lower Gwynedd PA) Hook ; III John W. (Warminster PA) Stevens Travis E. (Ambler PA), Process for preparing large dimension emulsion polymer particles, polymer product and uses thereof.
상세보기
Mathiowitz Edith ; Chickering ; III Donald ; Jong Yong S. ; Jacob Jules S., Process for preparing microparticles through phase inversion phenomena.
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Kelley Donald J. (Lunenburg MA) Williams David J. (Lunenburg MA) Slovenkai Stephen V. (Leominster MA), Process for preparing styrenic polymer particles.
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Timm Edward E. (Coleman MI) Leng Douglas E. (Midland MI), Process for preparing uniformly sized polymer particles by suspension polymerization of vibratorily excited monomers in.
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Naito ; Kenji, Process for producing finely divided porous polymer particles.
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Garnier Patrick (Paris FRX) Abriou Daniel (Gagny FRX) Coquillon Michel (Chauconin/Neufmontiers FRX), Process for producing glass microspheres.
상세보기
Kawamura Yoshihide (Shizuoka JPX) Tanibe Hiroaki (Shizuoka JPX) Kurahashi Itsuo (Shizuoka JPX) Seo Hiroshi (Souka JPX) Nakajima Saburo (Koshigaya JPX), Process for producing granular porous chitosan.
상세보기
Vanderhoff John W. ; Lu Cheng Xun ; Lee Clarence C. ; Tsai Chi-Chun, Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained.
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Vanderhoff, John W.; Lu, Cheng Xun; Lee, Clarence C.; Tsai, Chi-Chun, Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained.
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Lange Peter M. (Leverkusen DEX) Strver Werner (Cologne DEX), Process for the preparation of bead polymers of uniform particle size by polymerization of microencapsulated monomer.
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Hattori Masayuki (Bethlehem PA) Sudol E. David (Bethlehem PA) El-Aasser Mohamed S. (Bethlehem PA), Process for the preparation of cross-linked polymer particles.
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Jain Mukesh (Quebec CAX) Nadkarni Sadashiv (Quebec CAX), Process for the preparation of hollow microspheres.
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Bayer Ernst (Bei der Ochsenweide 17 D-7400 Tbingen DEX) Rapp Wolfgang (Ursrainer Ring 105 D-7400 Tbingen DEX), Process for the preparation of monodispersed polymer beads.
상세보기
Afghan Madjid (Amsterdam NLX) Sponselee Josephus G. (Amsterdam NLX), Process for the preparation of silica spheres.
상세보기
Unger Evan C., Prodrugs comprising fluorinated amphiphiles.
상세보기
Stowell Donald E. (Oklahoma City OK) Jackson R. Tom (Ponca City OK) Bendig Larry L. (Ponca City OK), Production of high strength alumina spheres by hydrogelling corresponding slurries.
상세보기
Rembaum Alan (Pasadena CA) Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chang Manchium (Los Angeles CA), Production of monodisperse, polymeric microspheres.
상세보기
Takada Shigeyuki (Salt Lake City UT) Uda Yoshiaki (Takarazuka JPX) Ogawa Yasuaki (Kyoto JPX), Prolonged release microparticle preparation and production of the same.
상세보기
Takada Shigeyuki (Salt Lake City UT) Uda Yoshiaki (Takarazuka JPX) Ogawa Yasuaki (Ohyamazaki-cho JPX), Prolonged release microparticle preparation and production of the same.
상세보기
Day Delbert E. (Rolla MO) Ehrhardt Gary J. (Columbia MO), Radioactive glass microspheres.
상세보기
Handa Hajime (Kyoto JPX) Yonekawa Yasuhiro (Kyoto JPX) Yamagata Sen (Kyoto JPX) Taki Waro (Kyoto JPX) Ikada Yoshito (Uji JPX) Iwata Hiroo (Uji JPX), Releasable balloon catheter.
상세보기
Hager Patrick J. (Woodbury MN) Goetz Richard J. (Woodbury MN), Repulpable plastic films.
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Hager Patrick J. (Woodbury MN) Goetz Richard J. (Woodbury MN), Repulpable plastic films.
상세보기
Urabe Itaru,JPX ; Yomo Tetsuya,JPX ; Yamamoto Keizo,JPX ; Sunohara Hideki,JPX ; Kamaguchi Ryosei,JPX ; Hatano Yumi,JPX, Seamless capsule for synthesizing biopolymer and method for producing the same.
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Robert S. Langer ; Andreas Lendlein DE, Shape memory polymers.
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Hubbard William G., Soft tissue augmentation material.
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William G. Hubbard, Soft tissue augmentation material.
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Lo Ray Jia (San Leandro CA) Villafranca Ernesto Noe (Oakland CA), Solid microspheres for agriculturally active compounds and process for their production.
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Baker Rodney C. (Hertsfordshire GB2), Solid pharmaceutical composition.
상세보기
Courteille Frederic (Cachan FRX) Coutel Anne (Antony FRX) Lebreton Guy (Gif-Sur-Yvette FRX) Veillard Michel (Sceaux FRX), Solid porous unitary form comprising micro-particles and/or nano-particles, and its preparation.
상세보기
Berlowitz-Tarrant Laurence ; Tangredi Timothy N. ; Wnek Gary E. ; Nicolosi Robert J., Sulfonated multiblock copolymer and uses therefor.
상세보기
Cercone Ronald J. (East Lyme CT) Gatto Dom L. (Branford CT) Gertzman Arthur A. (Woodbridge CT) Valentine Douglas R. (Oakdale CT), Surgical sponge device.
상세보기
Hidaka Osafumi (Tokyo JPX) Sakai Tomoki (Tokyo JPX) Sakano Toyoaki (Tokyo JPX), Sustained release pharmaceutical plaster.
상세보기
Hidaka Osafumi (Tokyo JPX) Sakai Tomoki (Tokyo JPX), Sustained release pharmaceutical preparation.
상세보기
Palmacci Stephen (Walpole MA) Josephson Lee (Arlington MA), Synthesis of polysaccharide covered superparamagnetic oxide colloids.
상세보기
Grabenkort Richard W., Syringe barrel for lyophilization, reconstitution and administration.
상세보기
Hofstetter John M. (Vernon Hills IL) O\Neil John A. (Mundelein IL) Grabenkort Richard W. (Barrington IL), Syringe system accommodating separately storable prefilled containers for two constituents.
상세보기
Grabenkort Richard W. ; Hofstetter John M. ; O'Neil John A., Syringe system accomodating seperate prefilled barrels for two constituents.
상세보기
Dormandy ; Jr. Ray H. (South San Francisco CA) Bell Julie D. (South San Francisco CA), System for artificial vessel embolization and devices for use therewith.
상세보기
Felicelli Robert ; Grabenkort Richard W. ; Lasaitis Con A. ; Smith Gary N. ; Ziegler John S., System for storing mixing and administering a drug.
상세보기
Sahatjian, Ronald A.; Boock, Robert, Systems and methods for delivering flowable substances for use as implants and surgical sealants.
상세보기
Motta Louis J. (14501 Tupper St. ; Ste. 60 Panorama City CA 91402), Tandem syringe.
상세보기
Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Targeted gas and gaseous precursor-filled liposomes.
상세보기
Guiles Marvin A. ; Haghighat Ross ; Singh Anant ; Lerner Rochelle, Temperature-controlled induction heating of polymeric materials.
상세보기
Ersek Robert A. (62 Pascal Austin TX 78746) Beisang ; III Arthur A. (5883 Carlson St. Shoreview MN 55126) Beisang Arthur A. (1300 Ingerson Rd. Arden Hills MN 55112), Textured micro implants.
상세보기
Wallace Sidney (Houston TX) Yang David (Sugar Lan TX) Wallace Michael (Houston TX) Li Chun (Houston TX) Kuang Li-Ren (Houston TX), Therapeutic and diagnostic use of modified polymeric microcapsules.
상세보기
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic delivery systems related applications.
상세보기
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic drug delivery systems.
상세보기
Unger Evan C. ; Fritz Thomas A. ; Matsunaga Terry ; Ramaswami VaradaRajan ; Yellowhair David ; Wu Guanli, Therapeutic drug delivery systems.
상세보기
Kunz Lawrence L. ; Klein Richard A. ; Reno John M. ; Grainger David J.,GBX ; Metcalfe James C.,GBX ; Weissberg Peter L.,GBX ; Anderson Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
상세보기
Kennedy Joseph P. (Akron OH) Puskas Judit E. (Akron OH) Kaszas Gabor (Akron OH) Hager William G. (Akron OH), Thermoplastic elastomers of isobutylene and process of preparation.
상세보기
Kennedy, Joseph P.; Puskas, Judit E.; Kaszas, Gabor; Hager, William G., Thermoplastic elastomers of isobutylene and process of preparation.
상세보기
Goupil, Dennis W.; Chaouk, Hassan; Holland, Troy; Asfaw, Bruktawit T.; Goodrich, Stephen D.; Latini, Lucas, Tissue bulking and coating compositions.
상세보기
Klein Dean A., Tissue injectable composition.
상세보기
Lawin Timothy P. ; Klein Dean, Tissue injectable composition and method of use.
상세보기
Dean A. Klein, Tissue marking using biocompatible microparticles.
상세보기
Evans ; III Russell Morrison ; Uber ; III Arthur E., Total system for contrast delivery.
상세보기
Gilson Paul,IEX ; Brady Eamon,IEX, Transcatheter occluding implant.
상세보기
Ersek Robert A. (62 Pascal Austin TX 78746) Beisang Arthur A. (1300 Ingerson Rd. Arden Hills MN 55112) Beisang ; III Arthur A. (5883 Carlson St. Shoreview MN 55126), Treatment of urological and gastric fluid reflux disorders by injection of mmicro particles.
상세보기
Vidal Claude ; Redmond Russell ; Plyley Alan K., Two component fluid dispenser.
상세보기
Porter Thomas R. (Omaha NE), Ultrasound contrast agents and methods for their manufacture and use.
상세보기
Freed Jeffrey S. (New York NY), Use of injectable biomaterials for the repair and augmentation of the anal sphincters.
상세보기
Modi Pankaj (1928 Main St. W. Apt. 608 Hamilton CAX L8S 1J4 ), Vaccine delivery system for immunization, using biodegradable polymer microspheres.
상세보기
Hargrove William W. (Indianapolis IN) Harris Dale C. (Fairland IN) Akers Michael J. (Greenwood IN) Sperry Charles R. (Westport CT), Vacuum vial infusion system.
상세보기
Greene ; Jr. George R. ; Rosenbluth Robert F. ; Cox Brian J., Vascular embolization with an expansible implant.
상세보기
Rudnick, James J., Vascular plug delivery system.
상세보기
Sancoff Gregory E. ; Doyle Mark C. ; Field Frederic P., Vial adaptor for a liquid delivery device.
상세보기
Fowles Thomas A. ; Weinberg Robert J. ; Progar Thomas J., Vial connecting device for a sliding reconstitution device with seal.
상세보기
Thibault Jean Claude,FRX ; Jansen Hubert,FRX, Vial transferset and method.
상세보기
Morgan Tamela A. (Olmsted Township ; Cuyahoga County OH) Julian Gary L. (Parma OH) Stanislawczyk Vic (North Ridgeville OH), Vinylidene chloride emulsion interpolymer composition.
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Lund David, Windshield visor for motor vehicles.
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이 특허를 인용한 특허 (42) 인용/피인용 타임라인 분석

Flanagan, Aiden, Bioabsorbable metal medical device and method of manufacture.
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Atanasoska, Liliana; Weber, Jan; Warner, Robert W., Bioerodible endoprostheses and methods of making the same.
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Atanasoska, Liliana; Weber, Jan; Warner, Robert W.; Grovender, Amy, Bioerodible endoprostheses and methods of making the same.
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Boismier, Dennis A.; Girton, Timothy S.; Larsen, Steven R.; Shedlov, Matt; Merdan, Ken; O'Brien, Barry, Bioerodible endoprostheses and methods of making the same.
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Weber, Jan, Bioerodible endoprostheses and methods of making the same.
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Radhakrishnan, Rajesh; Chandrasekaran, Chandru; Schewe, Scott R.; Merdan, Ken, Bioerodible endoprosthesis.
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Weber, Jan, Bioerodible endoprosthesis.
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Weber, Jan; Atanasoska, Liliana; Schewe, Scott, Bioerodible endoprosthesis with biostable inorganic layers.
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Stinson, Jonathan S., Bioerodible metallic ENDOPROSTHESES.
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Atanasoska, Liliana; Rahi, Mourad; Warner, Robert W., Block copolymer-coated endoprosthesis.
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DiCarlo, Paul; Casey, II, Thomas V.; Mangin, Stephan P., Embolization.
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DiCarlo, Paul; Casey, II, Thomas V.; Mangin, Stephan P., Embolization.
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Atanasoska, Liliana; Radhakrishnan, Rajesh; Arcand, Ben; Warner, Robert W., Endoprostheses.
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Weber, Jan, Endoprosthesis.
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Weber, Jan; Feng, James Q.; Atanasoska, Liliana, Endoprosthesis having a fiber meshwork disposed thereon.
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Weber, Jan; Atanasoska, Liliana, Endoprosthesis with three-dimensional disintegration control.
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Shaw, William J., Medical devices.
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Stinson, Jonathan S., Medical devices and method for making the same.
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Girton, Timothy S., Medical devices and methods of making the same.
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Weber, Jan; Holman, Thomas J.; Eidenschink, Tracee, Medical devices including composites.
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Weber, Jan, Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides.
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Penner, Avi; Gileadi, Eilezer, Method and device for electrochemical formation of therapeutic species in vivo.
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Boyan, Barbara Dale; Kinney, Ramsey Christian; Schwartz, Zvi, Microencapsulation of cells in hydrogels using electrostatic potentials.
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Casey, II, Thomas V.; Damiano, Bud, Mixing and delivery of therapeutic compositions.
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Wang, Xiaorong; Foltz, Victor J.; Kelley, Edward D., Modified rubber compositions and methods of preparation.
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Cruise, Gregory M.; Plotkin, Steve; Wu, Xinping, Particles.
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Cruise, Gregory M.; Plotkin, Steve; Wu, Xinping, Particles.
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Cruise, Gregory M.; Hincapie, Gloria; Harris, Clayton; Wu, Yue, Polymer films.
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Cruise, Gregory M.; Hincapie, Gloria; Harris, Clayton; Wu, Yue, Polymer films.
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Cruise, Gregory M.; Hincapie, Gloria; Harris, Clayton, Polymer particles.
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Cruise, Gregory M.; Hincapie, Gloria; Harris, Clayton, Polymer particles.
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Cruise, Gregory M.; Hincapie, Gloria; Harris, Clayton, Polymer particles.
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Hincapie, Gloria; Wu, Xinping; Wu, Yue; Cruise, Gregory M., Polymer particles.
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Plotkin, Steve; Cruise, Gregory M.; Keeley, Edward Michael; Yu, Renee; Harris, Clayton, Polymer particles.
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Plotkin, Steve; Cruise, Gregory M.; Keeley, Edward Michael; Yu, Renee; Harris, Clayton, Polymer particles.
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Lanphere, Janel; St. Pierre, Ernest J.; Kapoglis, Greg; Casey, II, Thomas V., Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient.
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Barman, Shikha P.; Thekkedath, Ritesh Vasudevan; Barman, Koushik; Cavanagh, Thomas; Hao, Tian; Leland, Thomas Bovard, Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof.
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Cavanagh, Thomas; Barman, Shikha P., Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof.
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Cavanagh, Thomas; Barman, Shikha P.; Hao, Tian; Leland, Thomas B.; Thekkedath, Ritesh V., Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof.
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Cavanagh, Thomas; Barman, Shikha P.; Hao, Tian; Leland, Thomas B.; Thekkedath, Ritesh V., Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof.
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Atanasoska, Liliana; Shippy, III, James Lee; Holman, Tom; Arney, Michael S.; Schoenle, Victor; Genovese, Frank; Feng, James Q.; Flanagan, Aiden; Weber, Jan, Self-buffering medical implants.
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Scheuermann, Torsten; Weber, Jan; Deng, Charles; Stinson, Jonathan S.; Larsen, Steven R.; Boismier, Dennis A.; Edick, Jacob D., Surface treated bioerodible metal endoprostheses.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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이 특허에 인용된 특허 (302) 인용/피인용 타임라인 분석

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