[특허]Nogo receptor antagonists

[미국특허] Nogo receptor antagonists 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/00 A61K-038/16 C07K-014/00 C07K-005/00 C07K-016/00
출원번호	US-0055163 (2005-02-10)
등록번호	US-7465705 (2008-12-16)
발명자 / 주소	Lee,Daniel H. S. Pepinsky,R. Blake Li,Weiwei Relton,Jane K. Worley,Dane S. Strittmatter,Stephen M. Sah,Dinah W. Y. Rabacchi,Sylvia A.
출원인 / 주소	Yale University Biogen Idec MA Inc.
대리인 / 주소	Sterne, Kessler, Goldstein & Fox P.L.L.C.
인용정보	피인용 횟수 : 19 인용 특허 : 21

초록 ▼

Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same.

대표청구항 ▼

The invention claimed is: 1. An isolated soluble Nogo receptor-1 polypeptide comprising amino acids 26-310 of SEQ ID NO:7 fused to immunoglobulin Fc; wherein said soluble Nogo receptor-1 polypeptide inhibits neurite outgrowth inhibition. 2. The soluble Nogo receptor-1 polypeptide of claim 1 joined to a signal sequence. 3. A composition comprising a pharmaceutically acceptable carrier and the soluble Nogo receptor-1 polypeptide of claim 1. 4. The composition of claim 3 further comprising one or more additional therapeutic agents. 5. The composition of claim 4, wherein said therapeutic agent is an anti-inflammatory agent. 6. The composition of claim 3, wherein said composition is formulated for administration by a route selected from the group consisting of parenteral administration, subcutaneous administration, intravenous administration, intramuscular administration, intraperitoneal administration, and microinfusion administration. 7. A method for inhibiting growth cone collapse of a neuron, comprising contacting the neuron with the soluble Nogo receptor-1 polypeptide of claim 1. 8. A method for decreasing the inhibition of neurite outgrowth or neurite sprouting in a neuron, comprising contacting the neuron with the soluble Nogo receptor-1 polypeptide of claim 1. 9. A method of promoting survival of a neuron at risk of dying, comprising contacting the neuron with an effective amount of the soluble Nogo receptor-1 polypeptide of claim 1. 10. A method of treating diabetic neuropathy in a mammal comprising administering to a mammal in need of said treatment an effective amount of the soluble Nogo receptor-1 polypeptide of claim 1. 11. A method of treating traumatic brain injury in a mammal comprising administering to a mammal in need of said treatment an effective amount of the soluble Nogo receptor-1 polypeptide of claim 1. 12. A method of treating spinal cord injury in a mammal comprising administering to a mammal in need of said treatment an effective amount of the soluble Nogo receptor-1 polypeptide of claim 1.

이 특허에 인용된 특허 (21) 인용/피인용 타임라인 분석

Steven M. Ruben ; Jian Ni ; Craig A. Rosen ; Ying-Fei Wei ; Paul Young ; Kimberly Florence ; Daniel R. Soppet ; Laurie A. Brewer ; Gregory A. Endress ; Kenneth C. Carter ; Michael Mucenski , 94 Human Secreted Proteins.
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Cousens Lawrence S. (San Francisco CA) Bell Graeme I. (San Francisco CA) Valenzuela Pablo D. T. (San Francisco CA), Adenovirus promoter system.
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Ruben, Steven M.; Ni, Jian; Rosen, Craig A.; Wei, Ying-Fei; Young, Paul; Florence, Kimberly; Soppet, Daniel R.; Brewer, Laurie A.; Endress, Gregory A.; Carter, Kenneth C.; Mucenski, Michael; Ebner, R, Antibodies to secreted protein HCEJQ69.
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Ruben, Steven M.; Rosen, Craig A.; LaFleur, David W., Antibodies to secreted protein HCEJQ69.
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Adair John Robert,GBX ; Bodmer Mark William,GBX ; Mountain Andrew,GBX ; Owens Raymond John,GBX, CDR grafted anti-CEA antibodies and their production.
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Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
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Koszinowski Ulrich H. (Tbingen DEX) Keil Gnther M. (Tbingen DEX) Dorsch-Hsler Karoline (Zrich CHX) Schaffner Walter (Weiningen CHX), Deoxyribonucleic acid segment from a virus.
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Ladner Robert C. (Ijamsville MD) Guterman Sonia K. (Belmont MA) Roberts Bruce L. (Milford MA) Markland William (Milford MA) Ley Arthur C. (Newton MA) Kent Rachel B. (Boxborough MA), Directed evolution of novel binding proteins.
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Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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Kronick Melvyn N. (Palo Alto CA) Little William A. (Palo Alto CA), Fluorescent immunoassay employing total reflection for activation.
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Nakatani Tomoyuki,JPX ; Gomi Hideyuki,JPX ; Wijdenes John,FRX ; Noguchi Hiroshi,JPX, Humanized B-B10.
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Carter Paul J. ; Presta Leonard G., Humanized antibodies and methods for making them.
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Maggio Edward T. (Redwood City CA), Kit for carrying out chemically induced fluorescence immunoassay.
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Litman David J. (Palo Alto CA) Harel Zvi (Stanford CA) Ullman Edwin F. (Atherton CA), Macromolecular environment control in specific receptor assays.
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Strittmatter,Stephen M.; Cate,Richard L.; Sah,Dinah W. Y., Nogo receptor homologs.
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Strittmatter,Stephen M., Nogo receptor-mediated blockade of axonal growth.
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Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
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Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
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Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
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Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
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Stinski Mark F. (Iowa City IA), Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence.
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이 특허를 인용한 특허 (19) 인용/피인용 타임라인 분석

Gruskin, Elliott A.; Iaci, Jennifer F.; Vecchione, Andrea M.; Kasperbauer, Sarah J.; Roy, Gargi, Compositions and methods for promoting neuronal outgrowth.
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Gruskin, Elliott A.; Iaci, Jennifer F.; Vecchione, Andrea M.; Kasperbauer, Sarah J.; Roy, Gargi, Compositions and methods for promoting neuronal outgrowth.
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Gruskin, Elliott A.; Iaci, Jennifer F.; Vecchione, Andrea M.; Kasperbauer, Sarah J.; Roy, Gargi, Compositions and methods for promoting neuronal outgrowth.
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Gruskin, Elliott A.; Iaci, Jennifer F.; Vecchione, Andrea M.; Kasperbauer, Sarah J.; Roy, Gargi, Compositions and methods for promoting neuronal outgrowth.
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Caggiano, Anthony O.; Iaci, Jennifer; Vecchione, Andrea; Hunter, Elizabeth, Compositions and methods of using chondroitinase ABCI mutants.
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Caggiano, Anthony O.; Iaci, Jennifer; Vecchione, Andrea; Hunter, Elizabeth, Compositions and methods of using chondroitinase ABCI mutants.
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Caggiano, Anthony O.; Iaci, Jennifer; Vecchione, Andrea; Markensohn, Elizabeth, Compositions and methods of using chondroitinase ABCI mutants.
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Caggiano, Anthony O.; Vecchione, Andrea; Iaci, Jennifer, Compositions and methods of using chondroitinase ABCI mutants.
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Caggiano, Anthony O.; Vecchione, Andrea; Iaci, Jennifer, Compositions and methods of using chondroitinase ABCI mutants.
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Caggiano, Anthony O.; Vecchione, Andrea; Iaci, Jennifer, Compositions and methods of using chondroitinase ABCI mutants.
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Caggiano, Anthony O.; Vecchione, Andrea; Iaci, Jennifer, Compositions and methods of using chondroitinase ABCI mutants.
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Gruskin, Elliott A.; Caggiano, Anthony O.; Roy, Gargi; Iaci, Jennifer; Zimber, Michael P., Fusion proteins for the treatment of CNS.
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Caggiano, Anthony O.; Gruskin, Elliott A.; Sheptovitsky, Yelena G.; Kasperbauer, Sarah, Methods of purifying chondroitinase and stable formulations thereof.
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Gruskin, Elliott A.; Tseng, Jack L.; Caggiano, Anthony O., Methods of reducing extravasation of inflammatory cells.
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Gruskin, Elliott A.; Tseng, Jack L.; Caggiano, Anthony O., Methods of reducing extravasation of inflammatory cells.
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Lee, Daniel H. S.; Pepinsky, R. Blake; Li, Weiwei; Relton, Jane K.; Worley, Dane S.; Strittmatter, Stephen M.; Sah, Dinah W. Y.; Rabacchi, Sylvia A., Nogo receptor antagonists.
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Strittmatter, Stephen M., Nogo receptor-mediated blockade of axonal growth.
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Gruskin, Elliott A.; D'Souza, Rohini; Roy, Gargi; Caggiano, Anthony O., Proteoglycan degrading mutants for treatment of CNS.
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Strittmatter, Stephen M., Reactivation of axon growth and recovery in chronic spinal cord injury.
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[미국특허] Nogo receptor antagonists 원문보기