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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0688561 (2003-10-17) |
등록번호 | US-7488601 (2009-02-10) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 52 인용 특허 : 462 |
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the
A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.
What is claimed is: 1. A method for detecting an abused sensor adapted for determining a concentration of a medically significant component of a biological fluid, comprising the steps of: a) applying a signal having an AC component to the sensor; b) measuring an AC response to the signal; and c) us
What is claimed is: 1. A method for detecting an abused sensor adapted for determining a concentration of a medically significant component of a biological fluid, comprising the steps of: a) applying a signal having an AC component to the sensor; b) measuring an AC response to the signal; and c) using the AC response to determine if the sensor is abused, wherein steps (a), (b) and (c) are performed before application of the biological fluid to the sensor. 2. The method of claim 1, wherein the AC response comprises an admittance. 3. The method of claim 1, wherein the signal is an AC signal. 4. The method of claim 1, wherein the AC response comprises phase angle information. 5. The method of claim 1, wherein the AC component of the signal has a frequency not less than 1 Hz and not greater than 20 kHz. 6. The method of claim 1, wherein the biological fluid is blood. 7. A method for detecting an abused sensor for determining a concentration of a medically significant component of a biological fluid placed upon the sensor, comprising the steps of: a) placing the biological fluid sample upon the sensor; b) applying a first signal to the biological fluid; c) measuring a current response to the first signal; d) repeating step (c) at least once; e) calculating a normalized Cottrell Failsafe Ratio using the current response data; f) applying a second signal having an AC component to the biological fluid; g) measuring an AC response to the second signal; and h) combining the normalized Cottrell Failsafe Ratio and the AC response to produce an indication of whether the sensor has been abused, wherein step (h) comprises calculating a FAILSAFE number as follows: description="In-line Formulae" end="lead"FAILSAFE=1000��arctan [NCFR/(fs0+fs1(Φ1-Φ2))]description="In-line Formulae" end="tail" where: 1000=scaling factor NCFR normalized Cottrell Failsafe Ratio fs0=constant fs1=constant Φ1=phase angle at a first frequency Φ2=phase angle at a second frequency; wherein a value of FAILSAFE below zero indicates an abused sensor and a value of FAILSAFE above zero indicates a non-abused sensor. 8. A method of determining a failure condition indicating an abused sensor in a blood glucose concentration test, comprising the steps of: a) applying a first test signal having an AC component to a test sample; b) measuring a first phase angle response to the first test signal; c) applying a second test signal having an AC component to the test sample; d) measuring a second phase angle response to the second test signal; and e) determining a failure condition value based upon the first phase angle response the second phase angle response and a predetermined Cottrell Failsafe Ratio, wherein step (e) is performed based at least in part upon evaluating: description="In-line Formulae" end="lead"arctan [CFR/(fs0+fs1(ΦA-ΦB)] description="In-line Formulae" end="tail" where: CFR=Cottrell Failsafe Ratio fs0=a constant fs1=a constant ΦA=first phase angle response ΦB=second phase angle response.
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