Method of producing pharmaceuticals or food supplements comprising pigmented polymer coatings
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B05D-003/00
B05D-007/00
B32B-005/16
출원번호
US-0539808
(2003-10-18)
등록번호
US-7494690
(2009-02-24)
우선권정보
DE-102 60 920(2002-12-20)
국제출원번호
PCT/EP03/011539
(2003-10-18)
§371/§102 date
20050620
(20050620)
국제공개번호
WO04/058224
(2004-07-15)
발명자
/ 주소
Petereit,Hans Ulrich
Meier,Christian
Roth,Erna
출원인 / 주소
Roehm GmbH & Co. KG
대리인 / 주소
Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
인용정보
피인용 횟수 :
1인용 특허 :
8
초록▼
The invention relates to a method for producing pharmaceuticals or parts thereof or food supplements or parts thereof, by coating substrates with a film-forming coating agent containing a pigment which is incompatible with the coating agent. The invention also relates to appliances for carrying out
The invention relates to a method for producing pharmaceuticals or parts thereof or food supplements or parts thereof, by coating substrates with a film-forming coating agent containing a pigment which is incompatible with the coating agent. The invention also relates to appliances for carrying out said method, especially a drum coater, a mushroom mixer, a fluidised bed appliance or a spray sifter comprising multiple spray devices.
대표청구항▼
The invention claimed is: 1. A method for producing pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof, comprising: preparing a sprayable solution, suspension or dispersion of a film-forming coating agent in a liquid; preparing a separate sprayable solution, suspension
The invention claimed is: 1. A method for producing pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof, comprising: preparing a sprayable solution, suspension or dispersion of a film-forming coating agent in a liquid; preparing a separate sprayable solution, suspension or dispersion of a pigment in a liquid; simultaneously spraying by spray application onto a substrate of the pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof with the solution, suspension or dispersion of a film-forming coating agent and the solution, suspension or dispersion of a pigment; thereby coating the substrate with the film-forming coating agent comprising the pigment; evaporating the liquid of each solution, suspension or dispersion; forming a uniformly pigmented film coating on the pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof; wherein the film-forming coating agent is a (meth)acrylate copolymer having cationic or anionic groups, the sprayable solution, suspension or dispersion of a film-forming coating agent and the sprayable solution, suspension or dispersion of a pigment are incompatible with respect to destabilization of the dispersion, coagulation, signs of inhomogeneity or similarly unwanted effects if combined before spraying, and the simultaneously spraying by spray application comprises one or more spray devices which separately spray liquids, singly or together, and separate spray beams of the one or more spray devices overlap. 2. The method according to claim 1, wherein the (meth)acrylate copolymer consists of 30 to 80% by weight free-radical polymerized C1 to C4 alkyl esters of acrylic or methacrylic acid and 70 to 20% by weight (meth)acrylate monomers having a tertiary amino group in the alkyl radical. 3. The method according to claim 1, wherein the (meth)acrylate copolymer consists of 40 to 60% by weight methacrylic acid and 60 to 40% by weight methyl methacrylate or 60 to 40% by weight ethyl acrylate. 4. The method according to claim 1, wherein the substrates are selected from the group consisting of active ingredient crystals, active ingredient-containing cores, tablets, granules, pellets and capsules. 5. The method according to claim 1, wherein the pigment incompatible with the coating agent is an aluminum pigment. 6. The method according to claim 1, wherein the pigment incompatible with the coating agent is selected from the group consisting of orange yellow S (E110, C.I. 15985, FD&C Yellow 6), indigo carmine (E132, C.I. 73015, FD&C Blue 2), tartrazine (E 102, C.I. 19140, FD&C Yellow 5), Ponceau 4R (E 125, C.I. 16255, FD&C Cochineal Red A), quinoline yellow (E 104, C.I. 47005, FD&C Yellow 10), eythrosine (E127, C.I. 45430, FD&C Red 3), azorubine (E 122, C.I. 14720, FD&C Carmoisine), amaranth (E 123, C.I. 16185, FD&C Red 2), and acid brilliant green (E 142, C.I. 44090, FD&C Green S). 7. The method according to claim 1, wherein the one or more spray devices comprises two or more two-fluid nozzles or one or more three-fluid nozzles. 8. The method according to claim 1, wherein the spray application takes place in a drum coater, a coating pan, a fluidized bed apparatus or a spray sifter. 9. The method according to claim 8, wherein the spray application takes place by spray devices as fixed installation. 10. The method for producing pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof, according to claim 1, further comprising applying a sealing layer to the substrate of the pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof before the simultaneously spraying by spray application onto the substrate of the pharmaceuticals or parts of pharmaceuticals or food supplements or parts thereof with the solution.
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이 특허에 인용된 특허 (8)
Petereit Hans-Ulrich (Darmstadt DEX) Assmus Manfred (Bickenbach DEX) Lehmann Klaus (Rossdorf DEX), Aqueous film coating agent for solid medicaments.
Bauer Kurt H. (Freiburg DEX) Osterwald Hermann (Freiburg DEX) Lehmann Klaus (Rossdorf DEX) Dreher Dieter (Bickenbach DEX), Coating agent for medicaments and methods for making and using the same.
Beckert, Thomas; Petereit, Hans-Ulrich; Dressman, Jennifer; Rudolph, Markus, Multi-particulate form of medicament, comprising at least two differently coated forms of pellet.
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