Method for packaging of phials in a sterile environment, and apparatus for carrying out the aforesaid method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B67C-007/00
B65B-055/10
B65B-055/04
B65B-031/02
B65B-003/00
B65B-007/28
출원번호
UP-0685865
(2007-03-14)
등록번호
US-7523596
(2009-07-01)
우선권정보
IT-BO2006A0183(2006-03-15)
발명자
/ 주소
Dovesi, Pietro
대리인 / 주소
Sapone, William J.
인용정보
피인용 횟수 :
5인용 특허 :
10
초록▼
The method for packaging of phials in a sterile environment comprises, subsequently: moving of each empty phial (1), according to a forwarding direction (K), from an input section toward a filling station (R); inserting of a dosed quantity of pharmaceutical products (F) inside the phial (1); transpo
The method for packaging of phials in a sterile environment comprises, subsequently: moving of each empty phial (1), according to a forwarding direction (K), from an input section toward a filling station (R); inserting of a dosed quantity of pharmaceutical products (F) inside the phial (1); transporting the filled phial (1) toward a closing station (8); closing said phial (1). It is moreover provided that a first laminar flow (H) of sterilized air, having a horizontal direction, is applied at least to the upper edges (1h) which define corresponding input mouths of the phials (1), at least during the aforesaid phases of filling and closing of phials (1), as well as during their transfer from the filling station (R) to the closing station (8).
대표청구항▼
The invention claimed is: 1. A method for filling and closing phials in a sterile environment comprising: providing a first sterile chamber and a second sterile chamber which form the sterile environment, the first sterile chamber and the second sterile chamber separated by a wall having an opening
The invention claimed is: 1. A method for filling and closing phials in a sterile environment comprising: providing a first sterile chamber and a second sterile chamber which form the sterile environment, the first sterile chamber and the second sterile chamber separated by a wall having an opening therein; in the second sterile chamber, moving a plurality of empty phials along a first conveying line and at a line input section, transferring each of the empty phials one at a time to a ring conveyor; using the ring conveyor for moving the empty phials from the second sterile chamber through a first intermediate position into the first sterile chamber, and transporting the empty phials towards a filling station; filling each phial at the filling station with a pre-defined amount of pharmaceutical products; transporting each one of said filled phials, using the ring conveyor, towards a closing station; at said closing station, closing said phials filled with said pharmaceutical products; using the ring conveyor for moving each one of said filled and closed phials from the first sterile chamber into the second sterile chamber at a second intermediate position as the filled and closed phials advance towards a line output section; at the line output section, located in the second sterile chamber, transferring the filled and closed phials from the ring conveyor to a second conveying line; wherein the opening in the wall has a portion of the ring conveyor passing therethrough, the second sterile chamber surrounding the portion of the ring conveyor disposed between the second intermediate position, the line output section where each filled and closed phial is transferred to the second conveying line, the line input section where each empty phial is transferred to the ring conveyor, and the first intermediate position; applying a first laminar flow of sterilized air in said first sterile chamber, oriented at a horizontal angle at least to the upper edges of said phials at least during the filling and closing of said phials, as well as during their conveying toward said filling station and away from said closing station; and, applying a second vertical laminar flow of sterilized air in the second sterile chamber, oriented top-down, at least to the upper edges of phials during their transport between the first conveyor line, the line input section and the first intermediate position where the phials are loaded onto the ring conveyor, and during transport of the filled and closed phials from the second intermediate position to said line output station and onto said second conveying line. 2. The method according to claim 1, wherein said first laminar flow of sterilized air is oriented horizontally. 3. An apparatus for filling and closing phials in a sterile environment, the apparatus cooperating with a conveying line of said phials, said conveying line moving according to a given transporting direction, said apparatus comprising: a first sterile chamber and a second sterile chamber forming said sterile environment, the first sterile chamber and the second sterile chamber separated by a wall, the wall having an opening therein a ring conveyor passing through the opening, the ring conveyor having a first portion disposed in the first sterile chamber and a second portion disposed in the second sterile chamber; a filling station, cooperating with said portion of the ring conveyor disposed in the first sterile chamber, the filling station dosing an amount of pharmaceutical products inside each of phials located at the said filling station; a closing station for applying a cap to each of said filled phials, cooperating with said portion of said ring conveyor disposed in said first sterile chamber and arranged downstream of said filling station with respect to said forwarding direction, a first air flow generator, for generating a first substantially horizontal laminar flow of sterilized air, fit to effect constantly at least the upper edges defining corresponding input mouths of said phials, at least during said phials filling and closing phases, as well as during their transfer between said filling station and said closing station; and, a second air flow generator located outside said first sterile chamber, fit to create a second vertical laminar flow of sterilized air oriented top-down, which effects at least the upper edges defining corresponding input mouths of said phials, when said phials are empty and being transported from an input line to the portion of the ring conveyor disposed in the second sterile chamber, and when said filled and closed phials are being transported from the ring conveyor to a second output conveying line. 4. Apparatus according to claim 3, wherein said second laminar flow of sterilized air created by said second air flow generator moreover effects at least said upper edges of said phials, when filled and closed, transported by said line between a second intermediate section, located at said opening, and an output section. 5. Apparatus according to claim 3, wherein said filling station comprises a telescopically adjustable tower carrying a dosing disc fit to put said dosed amount of pharmaceutical products inside each of said phials positioned at the filling station. 6. Apparatus according to claim 3, wherein said first laminar flow of sterilized air, created by said first air flow generator, is oriented horizontally.
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이 특허에 인용된 특허 (10)
Rebmann Manfred (Weinstadt DEX) Rothermel Otto (Stuttgart DEX) Stirnkorb Willi (Waiblingen-Hegnach DEX), Apparatus for aseptic packaging.
Lawecki Mark (Apollo PA) Gelblum Eugene A. (Mt. Lebanon PA) Robinson Michelle (Zelienople PA) Wolstenholme Ralph E. (Westfield PA) Wolstenholme Eugene B. (Southampton PA), Isolation module for molding and packaging articles substantially free from contaminants.
Dastoli Frank R. (Arlington TX) Senkowski Bernard Z. (Fort Worth TX) Wagener Dieter W. (Fort Worth TX) Bogdanffy George H. (Fort Worth TX) Vin Gaurang R. (Arlington TX), Means and method for aseptic particle-free production of articles.
van der Meijden, Wim; Holsink, J. A. M.; Miltenburg, W. H. Th.; Fitzgerald, Sean; Fiere, Jeroen Pieter; Mueller, Chad; Murray, Christopher; Bellmore, David, Method for aseptic filling of pouches.
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