IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
UP-0931474
(2004-08-31)
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등록번호 |
US-7524335
(2009-07-01)
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발명자
/ 주소 |
- Slivka, Michael A.
- Niederauer, Gabriele G.
- Kieswetter, Kristine
- Leatherbury, Neil C.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
13 인용 특허 :
65 |
초록
▼
A fiber-reinforced, polymeric implant material useful for tissue engineering, and method of making same are provided. The fibers are preferably aligned predominantly parallel to each other, but may also be aligned in a single plane. The implant material comprises a polymeric matrix, preferably a bio
A fiber-reinforced, polymeric implant material useful for tissue engineering, and method of making same are provided. The fibers are preferably aligned predominantly parallel to each other, but may also be aligned in a single plane. The implant material comprises a polymeric matrix, preferably a biodegradable matrix, having fibers substantially uniformly distributed therein. Inorganic particles may also be included in the implant material. In preferred embodiments, porous tissue scaffolds are provided which facilitate regeneration of load-bearing tissues such as articular cartilage and bone. Non-porous fiber-reinforced implant materials are also provided herein useful as permanent implants for load-bearing sites.
대표청구항
▼
The invention claimed is: 1. A fiber-reinforced, biodegradable, porous implant material comprising a polymeric matrix having biodegradable inorganic particles substantially uniformly distributed therein and having fibers of a length no greater than about one cm substantially uniformly distributed t
The invention claimed is: 1. A fiber-reinforced, biodegradable, porous implant material comprising a polymeric matrix having biodegradable inorganic particles substantially uniformly distributed therein and having fibers of a length no greater than about one cm substantially uniformly distributed therein in a predominantly parallel orientation, wherein pores of the material are substantially aligned with the fibers and a ratio of the volume of the fibers to a sum of the volume of the polymer forming the polymeric matrix, the volume of the fibers, and the volume of the inorganic particles is between about 5% to about 50%. 2. The implant material of claim 1, where the pore volume of the implant material is between about 50% and about 80%. 3. The implant material of claim 1, wherein the particles are calcium sulfate or a salt of calcium phosphate. 4. The implant material of claim 1, wherein the size of the particles is between about 0.5 and about 2000 microns. 5. The implant material of claim 4, wherein the size of the particles is between about 8 and about 300 microns. 6. The implant material of claim 1 further comprising autologous or allogenic tissue. 7. The implant of claim 6 wherein the autologous or allogenic tissue is minced or particulated. 8. The implant of claim 6 wherein the tissue is dermal tissue, cartilage, ligament, tendon, or bone. 9. The implant of claim 1 further comprising bioactive agents. 10. A fiber-reinforced, biodegradable porous implant material comprising a polymeric matrix having biodegradable inorganic particles substantially uniformly distributed therein and having synthetic fibers of a length no greater than about one cm substantially uniformly distributed therein in a predominantly parallel orientation, wherein pores of the material are substantially aligned with the fibers and a ratio of the volume of the inorganic particles to a sum of the volume of the inorganic particles, the volume of the fibers, and the volume of the polymer forming the polymeric matrix is between about 2% to about 60%. 11. The implant material of claim 10 wherein the implant is a three dimensional structure having an axis with which the pores of the material and the fibers are aligned with, where the axis defines a primary direction of loading of the implant after its placement in a defect in a load bearing tissue. 12. The implant material of claim 1 wherein the implant is a three dimensional structure having an axis with which the pores of the material and the fibers are aligned with, where the axis defines a primary direction of loading of the implant after its placement in a defect in a load bearing tissue. 13. The implant material of claim 10 further comprising autologous or allogenic tissue. 14. The implant of claim 13 wherein the autologous or allogenic tissue is minced or particulated. 15. The implant of claim 13 wherein the tissue is dermal tissue, cartilage, ligament, tendon, or bone. 16. The implant of claim 10 further comprising bioactive agents. 17. A fiber-reinforced, biodegradable, porous implant material comprising a polymeric matrix having biodegradable inorganic particles substantially uniformly distributed therein and having fibers of a length no greater than about one cm substantially uniformly distributed therein in a predominantly parallel orientation, wherein a ratio of the volume of the fibers to a sum of the volume of the polymer forming the polymeric matrix, the volume of the fibers, and the volume of the inorganic particles is between about 5% to about 50% and the implant is a three dimensional structure having an axis with which the pores of the material and the fibers are aligned with, wherein the axis defines a primary direction of loading of the implant after its placement in a defect in a load bearing tissue. 18. A fiber-reinforced, biodegradable, porous implant material comprising a polymeric matrix having biodegradable inorganic particles substantially uniformly distributed therein and having fibers of a length no greater than about one cm substantially uniformly distributed therein in a predominantly parallel orientation, wherein a ratio of the volume of the inorganic particles to a sum of the volume of the polymer forming the polymeric matrix, the volume of the fibers, and the volume of the inorganic particles is between about 2% to about 60% and the implant is a three dimensional structure having an axis with which the pores of the material and the fibers are aligned with, wherein the axis is aligned with the defines a primary direction of loading of the implant after its placement in a defect in a load bearing tissue.
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