Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from--H,
Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from--H,--OH or--OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both--H ozone is--H and the other is--OH,--OCH3 or--OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from--H or--OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.
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The invention claimed is: 1. The compound of formula where R1 is: (i) an unsubstituted aminomethylene group; or (ii) an aminomethylene group, wherein the amino portion of the aminomethylene group is protected with a protecting group selected from alkyl, alkenyl, alkylsilylalkoxyalkyl, alkoxyalky
The invention claimed is: 1. The compound of formula where R1 is: (i) an unsubstituted aminomethylene group; or (ii) an aminomethylene group, wherein the amino portion of the aminomethylene group is protected with a protecting group selected from alkyl, alkenyl, alkylsilylalkoxyalkyl, alkoxyalkyl, cyanoalkyl, alkoxyarylalkyl, cycloalkyl, nitroaryl, arylalkyl, and hydroxyarylalkyl; or (iii) an N-acylated aminomethylene group, wherein the acyl portion of the N-acylated aminomethylene group is aroyl, arylaroyl, haloaroyl, nitroaroyl, or an acyl group of the formula--CO--Ra where Ra is selected from alkyl, alkoxy, alkenyl, arylalkyl, arylalkenyl, aminoacid, and heterocyclyl, each of which is optionally substituted with halo, cyano, nitro, carboxyalkyl, alkoxy, aryl, aryloxy, heterocyclyl, heterocyclyloxy, alkyl, amino or substituted amino; and R18 is an OH group protected in the form of an alkyl ether, an alkoxyalkyl ether, an aryloxyalkyl ether, an alkoxyalkoxyalkyl ether, an alkylsilylalkoxyalkyl ether, an alkylthioalkyl ether, an arylthioalkyl ether, an azidoalkyl ether, a cyanoalkyl ether, a chloroalkyl ether, a heterocyclic ether, a cycloalkylalky ether, an alkenyl ether, a cycloalkyl ether, an alkylarylalkyl ether, an alkoxyarylalkyl ether, a nitroarylalkyl ether, a haloarylalkyl ether, an alkylaminocarbonylarylalkyl ether, an alkylsulfinylarylalkyl ether, or an alkylsilyl ether. 2. The compound according to claim 1, which is of formula: 3. The compound of formula where R1 is: (i) an unsubstituted aminomethylene group; or (ii) an aminomethylene group, wherein the amino portion of the aminomethylene group is protected with a protecting group selected from alkyl, alkenyl, alkylsilylalkoxyalkyl, alkoxyalkyl, cyanoalkyl, alkoxyarylalkyl, cycloalkyl, nitroaryl, arylalkyl, and hydroxyarylalkyl; or (iii) an N-acylated aminomethylene group, wherein the acyl portion of the N-acylated aminomethylene group is aroyl, arylaroyl, haloaroyl, nitroaroyl, or an acyl group of the formula--CO--Ra where Ra is selected from alkyl, alkoxy, alkenyl, arylalkyl, arylalkenyl, aminoacid, and heterocyclyl, each of which is optionally substituted with halo, cyano, nitro, carboxyalkyl, alkoxy, aryl, aryloxy, heterocyclyl, heterocyclyloxy, alkyl, amino or substituted amino; and R18 is a protected hydroxy group, wherein the oxygen atom together with the protecting group form: (a) an ether selected from an alkyl ether, an alkoxyalkyl ether, an aryloxyalkyl ether, an alkoxyalkoxyalkyl ether, an alkylsilylalkoxyalkyl ether, an alkylthioalkyl ether, an arylthioalkyl ether, an azidoalkyl ether, a cyanoalkyl ether, a chloroalkyl ether, a heterocyclic ether, a cycloalkylalky ether, an alkenyl ether, a cycloalkyl ether, an alkylarylalkyl ether, an alkoxyarylalkyl ether, a nitroarylalkyl ether, a haloarylalkyl ether, an alkylaminocarbonylarylalkyl ether, an alkylsulfinylarylalkyl ether, and an alkylsilyl ether; or (b) arylacyloxy, aryl alkyl carbonate, aliphatic carbonate, alkylsulfinylarylalkyl carbonate, alkyl carbonate, aryl haloalkyl carbonate, aryl alkenyl carbonate, arylcarbamate, alkylphosphinyl, alkylphosphinothioyl, or aryl alkyl sulphonate. 4. The compound according to claim 3, which is of the formula: 5. The compound of formula: where R1 is: (i) an aminomethylene group, wherein the amino portion of the aminomethylene group is protected with a protecting group selected from alkyl, alkenyl, alkylsilylalkoxyalkyl, alkoxyalkyl, cyanoalkyl, alkoxyarylalkyl, cycloalkyl, nitroaryl, arylalkyl, and hydroxyarylalkyl; or (ii) an N-acylated aminomethylene group, wherein the acyl portion of the N-acylated aminomethylene group is an acyl group of the formula--CO--Ra where Ra is selected from alkyl, alkoxy, alkenyl, arylalkenyl, aminoacid, and heterocyclyl, each of which is optionally substituted with halo, cyano, nitro, carboxyalkyl, alkoxy, aryloxy, heterocyclyl, heterocyclyloxy, alkyl, amino or substituted amino; and R18 is a protected hydroxy group, wherein the oxygen atom together with the protecting group form: (a) an ether selected from an alkyl ether, an alkoxyalkyl ether, an aryloxyalkyl ether, an alkoxyalkoxyalkyl ether, an alkylsilylalkoxyalkyl ether, an alkylthioalkyl ether, an arylthioalkyl ether, an azidoalkyl ether, a cyanoalkyl ether, a chloroalkyl ether, a heterocyclic ether, a cycloalkylalky ether, an alkenyl ether, a cycloalkyl ether, an alkylarylalkyl ether, an alkoxyarylalkyl ether, a nitroarylalkyl ether, a haloarylalkyl ether, an alkylaminocarbonylarylalkyl ether, an alkylsulfinylarylalkyl ether, and an alkylsilyl ether; or (b) arylacyloxy, aryl alkyl carbonate, aliphatic carbonate, alkylsulfinylarylalkyl carbonate, alkyl carbonate, aryl haloalkyl carbonate, aryl alkenyl carbonate, arylcarbamate, alkylphosphinyl, alkylphosphinothioyl, or aryl alkyl sulphonate. 6. The compound according to claim 5, which is of the formula:
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