Method of modulating cellular activity and agents useful for same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/195
A61K-031/185
A61K-043/00
출원번호
UP-0697655
(2003-10-31)
등록번호
US-7531575
(2009-07-01)
발명자
/ 주소
Weller, Michael
Wick, Wolfgang
Wischhusen, Jörg
Platten, Michael
출원인 / 주소
Eberhard Karls Universität Tübingin
대리인 / 주소
Bozicevic, Field & Francis LLP
인용정보
피인용 횟수 :
0인용 특허 :
3
초록▼
Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characterized by nitric oxide induced neur
Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characterized by nitric oxide induced neuronal damage.
대표청구항▼
The invention claimed is: 1. A method for the treatment of a condition in a mammal, said method comprising administering to said mammal an effective amount of tranilast or a pharmaceutically acceptable salt thereof, wherein said condition is multiple sclerosis. 2. The method of claim 1, wherein s
The invention claimed is: 1. A method for the treatment of a condition in a mammal, said method comprising administering to said mammal an effective amount of tranilast or a pharmaceutically acceptable salt thereof, wherein said condition is multiple sclerosis. 2. The method of claim 1, wherein said administering is selected from a group consisting of administering respiratorally, intratracheally, nasopharyngeally, intravenously, intraperitoneally, subcutaneously, intracranially, intradermally, intramuscularly, intraoccularly, intrathecally, intracereberally, intranasally, infusion, orally, rectally, via IV drip, patch and implant. 3. The method of claim 1, wherein said effective amount is from about 0.1 mg to about 1 mg per kilogram body weight per day of said mammal. 4. The method of claim 1, wherein said tranilast or pharmaceutically acceptable salt is administered orally. 5. The method of claim 1, wherein said administration is daily, weekly, or monthly. 6. The method of claim 1, wherein said effective amount is from about 0.1 μg to 2000 mg. 7. The method of claim 1, wherein said administering is via a tablet, troche, pill, capsule, syrup, suspension, wafer or elixir. 8. The method of claim 1, wherein said tranilast or a pharmaceutically acceptable salt thereof is present in a composition at least 1% by weight of said composition. 9. The method of claim 1, wherein said tranilast or a pharmaceutically acceptable salt thereof is present in a composition at about 5% to about 80% by weight of said composition.
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이 특허에 인용된 특허 (3)
Fernandez-Pol Jose A., Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method.
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