[특허]CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases

CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-005/20 C07K-016/00 C07K-016/28 C07K-016/18 A61K-039/395
출원번호	UP-0130206 (2005-05-17)
등록번호	US-7534605 (2009-07-01)
우선권정보	IL-130356(1999-06-08); IL-133647(1999-12-21)
발명자 / 주소	Naor, David Nedvetzki, Shlomo Golan, Itshak Kessel, Irina Melnik, Lora
출원인 / 주소	Yissum Research Development Company of the Hebrew University of Jerusalem
인용정보	피인용 횟수 : 2 인용 특허 : 86

초록

An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.

대표청구항 ▼

What is claimed is: 1. An isolated antibody comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NOs: 4 and 6. 2. The antibody of claim 1, wherein the antibody is an antibody or an antibody fragment. 3. The antibody of claim 2, wherein said antibody or antibody fragment is humanized. 4. The antibody of claim 2, wherein said antibody or said antibody fragment is selected from the group consisting of a Fab fragment, an Fv fragment, a single chain antibody and a single domain antibody. 5. The antibody of claim 2, wherein said antibody is produced by a cell hybridoma having the depository Accession No. CNCM I-3015 (F8:33 hybridoma) or CNCM I-3016 (F8:33-6-8-10 hybridoma). 6. The antibody of claim 1, comprises a light chain variable region comprising amino acid sequences of set forth by set forth by SEQ ID NO:22 (CDR1), SEQ ID NO:23 (CDR2) and SEQ ID NO:24 (CDR3) and a heavy chain variable region comprising amino acid sequences set forth by SEQ ID NO:26 (CDR1), SEQ ID NO:27 (CDR2) and SEQ ID NO: 28 (CDR3). 7. A pharmaceutical composition comprising as an active ingredient the antibody of claim 1 and a pharmaceutically effective carrier or diluent. 8. A kit for diagnosing a rheumatoid disease in a subject, the kit comprising the antibody of claim 1 and at least one reagent for detecting complexes including the antibody. 9. The kit of claim 8, wherein detecting said complexes is effected by an assay selected from the group consisting of immunohistochemistry, ELISA, RIA, Western blot analysis, FACS analysis, an immunofluorescence assay, and a light emission immunoassay. 10. The kit of claim 8, wherein the rheumatoid disease is a rheumatoid autoimmune disease. 11. The kit of claim 8, wherein the rheumatoid disease is selected from the group consisting of rheumatoid arthritis and psoriatic arthritis.

이 특허에 인용된 특허 (86)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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연합인증

CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 원문보기

초록

대표청구항 ▼

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연합인증

CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases 원문보기

초록

대표청구항 ▼

연구과제 타임라인

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이 특허에 인용된 특허 (86)

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