Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61P-009/00
A61K-031/553
A61K-031/554
A61K-031/675
C07F-009/553
C07F-009/00
C07D-081/02
C07D-081/00
출원번호
UP-0088058
(2005-03-23)
등록번호
US-7544678
(2009-07-01)
발명자
/ 주소
Marks, Andrew Robert
Landry, Donald W.
Deng, Shixian
Cheng, Zhen Zhuang
출원인 / 주소
The Trustees of Columbia University In the City of New York
대리인 / 주소
Wilmer Cutler Pickering Hale and Dorr LLP
인용정보
피인용 횟수 :
1인용 특허 :
131
초록▼
The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBP12.6 in a su
The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBP12.6 in a subject; to prevent exercise-induced sudden cardiac death in a subject; and to treat or prevent heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmia in a subject. The present invention further provides methods for identifying an agent that enhances binding of RyR2 and FKBP12.6, and agents identified by these methods. Additionally, the present invention provides methods for identifying agents for use in treating or preventing heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmia, and in preventing exercise-induced sudden cardiac death. Also provided are agents identified by such methods.
대표청구항▼
What is claimed is: 1. The compound S36: 2. A composition comprising S36 and a pharmaceutically acceptable carrier. 3. The composition of claim 2 wherein the carrier comprises carboxymethyl cellulose, crystalline cellulose, glycerin, gum arabic, lactose, magnesium stearate, methyl cellulo
What is claimed is: 1. The compound S36: 2. A composition comprising S36 and a pharmaceutically acceptable carrier. 3. The composition of claim 2 wherein the carrier comprises carboxymethyl cellulose, crystalline cellulose, glycerin, gum arabic, lactose, magnesium stearate, methyl cellulose, saline, sodium alginate, sucrose, starch, talc or water. 4. The composition of claim 2 which further includes one or more of an antioxidant, colorant, flavor improving agent, preservative, sweetener, binder or lubricant. 5. The composition of claim 2 in the form of a capsule, tablet, powder, granule, or suspension.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (131)
Reifschneider Walter (Walnut Creek CA) Bisabri-Ershadi Barat (Davis CA) Dripps James E. (Concord CA) Barron J. Brian (Benicia CA), ((N-heterocyclyl)carbonyl)phosphoramidothioate ester insecticides.
Reifschneider Walter (Walnut Creek CA) Bisabri-Ershadi Barat (Davis CA) Dripps James E. (Concord CA) Barron J. Brian (Benicia CA), ((N-heterocyclyl)carbonyl)phosphoramidothioate ester insecticides.
Husa Robert K. (Vernon Hills IL) Rafferty Michael F. (Buffalo Grove IL) Hagen Timothy J. (Glenview IL) Hallinan E. Ann (Evanston IL), 1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for trea.
Husa Robert K. (Vernon Hills IL) Hallinan E. Ann (Evanston IL) Lesne Michel (Kraainem BEX) Herin Marc (Montignies sur Sambre BEX), 2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and.
Hansen ; Jr. Donald W. (Skokie IL) Peterson Karen B. (Vernon Hills IL), 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical comp.
Hagen Timothy J. (Glenview IL) Clare Michael (Skokie IL) Rafferty Michael F. (Buffalo Grove IL) Hallinan E. Ann (Evanston IL), 2-, 3-, 5-, 8-, 10- and/or 11-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treatin.
Hansen ; Jr. Donald W. (Skokie IL) Peterson Karen B. (Vernon Hills IL), 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical composition.
Lawson John A. (Redwood City CA) Pandey Anjali (Menlo Park CA) Yasuda Dennis (Campbell CA) Tanabe Masato (Palo Alto CA), 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists.
Hallinan E. Ann (Evanston IL) Husa Robert K. (Vernon Hills IL) Peterson Karen B. (Vernon Hills IL), 8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and.
Koeller, Kevin J.; Tremont, Samuel J., Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake.
Ronald Keith Webber ; Richard C. Durley ; Alok K. Awasthi ; Arija A. Bergmanis ; Scott S. Ganser ; Timothy J. Hagen ; E. Ann Hallinan ; Donald W. Hansen, Jr. ; Brian S. Hickory ; Alan E. Moo, Amidino compound and salts thereof useful as nitric oxide synthase inhibitors.
Webber, Ronald Keith; Durley, Richard C.; Awasthi, Alok K.; Bergmanis, Arija A.; Fok, Kam F.; Ganser, Scott S.; Hagen, Timothy J.; Hallinan, E. Ann; Hansen, Jr., Donald W.; Hickory, Brian S.; Manning, Amidino compounds useful as nitric oxide synthase inhibitors.
Webber, Ronald Keith; Durley, Richard C.; Awasthi, Alok K.; Bergmanis, Arija A.; Fok, Kam F.; Ganser, Scott S.; Hagen, Timothy J.; Hallinan, E. Ann; Hansen, Jr., Donald W.; Hickory, Brian S.; Manning, Amidino compounds useful as nitric oxide synthase inhibitors.
Laborde, Edgardo; Robinson, Louise; Meng, Fanying; Peterson, Brian T.; Villar, Hugo O.; Anuskiewicz, Steven E.; Ma, Wenli; Matsumoto, Yukiharu; Baba, Kunihisa; Inagaki, Hideaki; Tanaka, Katsumasa; Is, Antagonist of MCP-1 function, and compositions and methods of use thereof.
Tomizuka, Kazuma; Yoshida, Hitoshi; Hanaoka, Kazunori; Oshimura, Mitsuo; Ishida, Isao, Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene.
Matsumoto Takashi (Stockholm SEX) Okada Takashi (Tokyo JPX) Mizusaki Shigenobu (Tokyo JPX), Desmosine derivatives having a disulfide bond and preparation of artificial antigen using the same.
Donald W. Hansen, Jr. ; Ronald Keith Webber ; Alok K. Awasthi ; Pamela T. Manning, Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
Margaret L. Grapperhaus ; James A. Sikorski ; Alok K. Awasthi ; Lijuan J. Wang ; Barnett S. Pitzele ; Donald W. Hansen, Jr. ; Pamela T. Manning, Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
Donald W. Hansen, Jr. ; Jeffrey S. Snyder ; Alan E. Moormann ; Alok K. Awasthi ; Ronald Keith Webber ; Thaddeus S. Franczyk ; Mahima Trivedi, Homoiminopiperidinyl hexanoic acid inhibitors of inducible nitric oxide synthase.
Koezuka,Yasuhiko; Yamaguchi,Yasunori; Motoki,Kazuhiro, Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof.
Tang, Y. Tom; Labat, Ivan; Drmanac, Radoje T.; Mize, Nancy; Nishikawa, Mitsuo; Chao, Cheng-Chi, Method of promoting stem cell proliferation or survival by contacting a cell with a stem cell factor-like polypeptide.
Chubinskaya, Susan; Hutchins, Jeff; Mollenhauer, Juergen; Tavares, Francis X.; Thomson, Stephen A.; Worley, Jennings F., Methods and compositions related to modulators of annexin and cartilage homeostasis.
Marks,Andrew Robert, Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2).
Andrew R. Marks ; Steven O. Marx, Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor.
Tandon,Narendra Nath; Sun,Bing; Nakamura,Takashi; Yamamoto,Naomasa, Platelet membrane glycoprotein VI (GPVI) DNA and protein sequences, and uses thereof.
Ishizaki Keiichirou (Kitsuregawa JPX) Onishi Noboru (Kitsuregawa JPX), Process for producing plantlets whereby the formation of a cell mass is induced.
McGee, Lawrence R.; Houze, Jonathan B.; Rubenstein, Steven M.; Hagiwara, Atsushi; Furukawa, Noboru; Shinkai, Hisashi, Quinolinyl and benzothiazolyl modulators.
Chandrakumar Nizal S. (Vernon Hills IL) Hansen ; Jr. Donald W. (Skokie IL) Peterson Karen B. (Vernon Hills IL) Pitzele Barnett S. (Skokie IL), Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use.
Housley John R. (Nottingham GB2) Jeffery James E. (Nottingham GB2) Nichol Kenneth J. (Nottingham GB2) Sargent Bruce J. (Nottingham GB2), Therapeutic 1,4-thiazepines.
Askanazi Jeffrey (233 Myrtle St. Haworth NJ 07641) Trimbo Susan (737 Ridge Ave. Evanston IL 60202), Use of branched chain amino acids to effect diaphragm contractility and fatigue.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.