Method for treating a bone defect with an organic/inorganic composite
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61K-009/00
C12N-005/00
C12N-011/00
C12N-011/14
C12N-011/02
C12N-011/10
C12N-011/12
C12N-011/08
출원번호
UP-0433725
(2006-05-12)
등록번호
US-7547449
(2009-07-01)
발명자
/ 주소
Gower, Laurie B.
Olszta, Matthew J.
Douglas, Elliot P.
Munisamy, Sivakumar
Wheeler, Donna L.
출원인 / 주소
University of Florida Research Foundation, Inc.
대리인 / 주소
Saliwanchik, Lloyd & Saliwanchik
인용정보
피인용 횟수 :
11인용 특허 :
19
초록▼
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a com
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.
대표청구항▼
We claim: 1. A method for treating a bone defect comprising: applying an organic/inorganic composite to the site of the bone defect; wherein said organic/inorganic composite comprises a fluid-swellable, fibrous matrix and an inorganic mineral, and said organic/inorganic composite is formed by conta
We claim: 1. A method for treating a bone defect comprising: applying an organic/inorganic composite to the site of the bone defect; wherein said organic/inorganic composite comprises a fluid-swellable, fibrous matrix and an inorganic mineral, and said organic/inorganic composite is formed by contacting an amorphous inorganic liquid-phase mineral precursor with said fluid-swellable, fibrous matrix, wherein said amorphous inorganic liquid-phase mineral precursor is absorbed into said fluid-swellable, fibrous matrix and coats and infiltrates, and subsequently hardens and crystallizes within, said fluid-swellable, fibrous matrix. 2. The method according to claim 1, wherein said organic/inorganic composite is applied as an injectable liquid, a film, a malleable putty, a malleable paste, a particulate, or a molded or preformed solid. 3. The method according to claim 1, wherein said fluid-swellable, fibrous matrix comprises a material selected from the group consisting of collagen, elastin, chitin, chitosan, and cellulose. 4. The method according to claim 1, wherein said inorganic mineral is selected from the group consisting of calcium phosphate, calcium carbonate, hydroxyapatite, strontium carbonate, calcium sulfate, calcium oxalate, magnesium-bearing calcium carbonate, and magnesium-bearing calcium, or combinations thereof. 5. The method according to claim 1, wherein said organic/inorganic composite further comprises a biologically active agent within said organic/inorganic composite. 6. The method according to claim 1, wherein said organic/inorganic composite is porous. 7. The method according to claim 1, wherein said fluid-swellable, fibrous matrix is biocompatible and bioresorbable. 8. The method according to claim 1, wherein said fluid-swellable, fibrous matrix is in the form of a scaffold, and wherein said scaffold is seeded with cells. 9. The method according to claim 8, wherein said cells are selected from the group consisting of bone marrow stem cells, osteoblasts, osteoclasts, osteocytes, blood cells, epithelial cells, odontoblast, ameloblasts, and neural cells, or combinations thereof. 10. The method according to claim 1, wherein said fluid-swellable, fibrous matrix is a film. 11. The method according to claim 1, wherein said organic/inorganic composite comprises a plurality of said fluid-swellable, fibrous matrices arranged as lamellae. 12. The method according to claim 11, wherein said lamellae are arranged concentrically around a central void for passage of endogenous or exogenous cells. 13. The method according to claim 1, wherein said organic/inorganic composite comprises a plurality of said fluid-swellable, fibrous matrices, and wherein said organic/inorganic composite further comprises an adhesive layer between each of said fluid-swellable, fibrous matrices.
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이 특허에 인용된 특허 (19)
Fairchild George Henry ; Thatcher Richard Louis, Acicular calcite and aragonite calcium carbonate.
Smestad Thomas L. (Palo Alto CA) Prows Daniel (Santa Clara CA) Chu George H. (Sunnyvale CA) Hendricks Diana M. (Brea CA), Gamma irradiation of collagen/mineral mixtures.
Lemons J. E. (c/o University of Alabama in Birmingham ; School of Dentistry ; Box 49 Birmingham AL 35294), Inorganic and organic composition for treatment of bone lesions.
Constantz Brent R. (Scott Valley CA) Barr Bryan (Mountain View CA) McVicker Kevin (Fremont CA), Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite.
Koukoulas, Alexander A.; Altman, Thomas E.; Matthew, M. C.; Amidon, Thomas E.; Mora, Fernand, Method to manufacture paper using fiber filler complexes.
Song Suk-Zu (Moorpark CA) Morawiecki Andrew (Camarillo CA) Pierce Glenn F. (Thousand Oaks CA) Pitt Colin G. (Westlake Village CA), Multi-layered collagen film compositions for delivery of proteins and methods of using same.
Silver Frederick H. (103 Springbrook Dr. Bangor PA 18013) Christiansen David (270 Altamont Pl. Somerville NJ 08876), Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Xenogeneic collagen/mineral preparations in bone repair.
Lin, Jo-Wen; Martz, Erik O.; Millets, Joel F.; Rosenthal, Daniel; Chow, David, Implant frames for use with settable materials and related methods of use.
Garigapati, Venkat R.; Hess, Brian J.; Kimsey, Cassandra L.; Murphy, Matthew E., Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods.
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