초록 ▼

A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer

A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.

대표청구항 ▼

The invention claimed is: 1. A composition comprising: a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60:40 to about 100:0; b) a chlorhexidine salt; and c) at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight

The invention claimed is: 1. A composition comprising: a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60:40 to about 100:0; b) a chlorhexidine salt; and c) at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight of the composition; wherein the emulsifier comprises: (i) at least one hydrophobic group selected from the group of: (A) an alkyl group of at least 24 carbon atoms; (B) an alkenyl group of at least 24 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 24 carbon atoms; and (ii) at least one hydrophilic group selected from the group of: (A) an ethylene oxide-and/or propylene oxide-containing group bonded to the hydrophobic group through an ether or ester bond and optionally terminated with a (C1-C36)alkyl ester, (C2-C36)alkenyl ester, or (C6-C36)alkaryl ester; (B) an alcohol group; (C) a polyhydric alcohol group; (D) an ester or ether group of a polyhydric alcohol or polyalkoxylated derivative thereof; (E) an ester or ether group of sorbitan or polyalkoxylated derivative thereof having 2-150 moles of alkylene oxide per mole of hydrophobic group; and (F) combinations thereof. 2. The composition of claim 1 wherein the composition has a melt temperature of greater than about 25° C. 3. The composition of claim 1 wherein the composition has a viscosity of at least about 25.5 centipoise at 23° C. 4. The composition of claim 1, wherein the chlorhexidine salt is selected from the group consisting of diacetate and digluconate salts. 5. The composition of claim 1, wherein the chlorhexidine salt is chlorhexidine digluconate. 6. The composition of claim 5, wherein the chlorhexidine digluconate is present at a concentration of 0.05 to 5.0%. 7. The composition of claim 1 further comprising at least one emollient distinct from the emulsifier. 8. The composition of claim 1 further comprising a therapeutic agent. 9. The composition of claim 1 wherein the emulsifier includes at least two hydrophobic groups. 10. The composition of claim 1 comprising at least two emulsifiers. 11. The composition of claim 7, wherein at least one emollient is insoluble in the hydroalcoholic solvent. 12. The composition of claim 7, wherein at least one emollient is essentially insoluble in water but soluble in the hydroalcoholic solvent. 13. The composition of claim 7 wherein the total emollient is present in a concentration of 3-30% by weight. 14. The composition of claim 7 wherein at least one emollient is a polyether/polysiloxane copolymers surfactant. 15. The composition of claim 14 wherein the polyether/polysiloxane copolymer surfactant has the following chemical structure: (CH3)3--Si--O--[Si(CH3)R11--O]x[Si(CH3)R8--O]y--Si(CH3) 3 where x+y=5-400, preferably 15-200, and R8 is a polyether substituted alkyl group with the structure: --R9--O(C2H4O)p(C3H 6O)qR10; where R9 is an alkyl group of 1 to 6 carbon atoms; R10 is hydrogen or an alky group of 1-22 carbon atoms; R11 is an alkyl group of 1 to 22 carbon atoms or phenyl; p=2-300, preferably 8-100; and q=0-100. 16. A composition comprising: a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60:40 to about 75:25; b) a chlorhexidine salt; and c) an emulsifier system comprised of at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight of the composition; wherein the emulsifier comprises: (i) at least one hydrophobic group selected from the group of: (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group of: (A) an ethylene oxide-and/or propylene oxide-containing group bonded to the hydrophobic group through an ether or ester bond and optionally terminated with a(C1-C36)alkyl ester, (C2-C36)alkenyl ester, or (C6-C36)alkaryl ester; (B) an alcohol group; (C) a polyhydric alcohol group; (D) an ester or ether group of a polyhydric alcohol or polyalkoxylated derivative thereof; (E) an ester or ether group of sorbitan or polyalkoxylated derivative thereof having 2-150 moles of alkylene oxide per mole of hydrophobic group; and (F) combinations thereof; wherein: the emulsifier system has a weight average hydrophile/lipophile balance of about 4 to about 16; the composition has a melt temperature of greater than about 35° C.; and the composition is stable. 17. The composition of claim 16 further comprising at least one emollient distinct from the emulsifier. 18. The composition of claim 16, wherein the chlorhexidine salt is selected from the group consisting of diacetate and digluconate salts. 19. The composition of claim 16, wherein the chlorhexidine salt is chlorhexidine digluconate. 20. The composition of claim 19, wherein the chlorhexidine digluconate is present at a concentration of 0.05 to 5.0%. 21. The composition of claim 16 further comprising a therapeutic agent. 22. The composition of claim 16 wherein the emulsifier includes at least two hydrophobic groups. 23. The composition of claim 16 comprising at least two emulsifiers. 24. The composition of claim 17, wherein at least one emollient is insoluble in the hydroalcoholic solvent. 25. The composition of claim 17, wherein at least one emollient is essentially insoluble in water but soluble in the hydroalcoholic solvent. 26. The composition of claim 17, wherein the total emollient is present in a concentration of 3-30% by weight. 27. The composition of claim 7 wherein at least one emollient is a polyether/polysiloxane copolymers surfactant. 28. The composition of claim 14 wherein the polyether/polysiloxane copolymer surfactant has the following chemical structure: (CH3)3--Si--O--[Si(CH3)R11--O]x[Si(CH3)R8--O]y--Si(CH3) 3 where x+y=5-400, preferably 15-200, and R8 is a polyether substituted alkyl group with the structure: --R9--O(C2H4O)p(C3H 6O)qR10; where R9 is an alkyl group of 1 to 6 carbon atoms; R10 is hydrogen or an alky group of 1-22 carbon atoms; R11 is an alkyl group of 1 to 22 carbon atoms or phenyl; p=2-300, preferably 8-100; and q=0-100. 29. A method of maintaining or improving the moisture content of skin, the method comprising applying to skin the composition of claim 1. 30. A method of maintaining or improving the moisture content of skin, the method comprising applying to skin the composition of claim 16.