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특허 상세정보

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내보내기 페이스북 공유 카카오톡 공유

Removal of molecular assay interferences

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C12Q-001/68    C12P-019/34    C12P-019/00   
미국특허분류(USC) 435/006; 435/091.2; 435/091.5; 435/091.52
출원번호 UP-0932122 (2001-08-16)
등록번호 US-7569342 (2009-08-24)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    King & Spalding L.L.P.
인용정보 피인용 횟수 : 8  인용 특허 : 237
초록
▼

Methods and systems for removing masking agents from test samples, e.g., DNA-containing samples obtained from living subjects, when they are submitted for or subjected to molecular assays. The present invention allows molecular assays of nucleic acids in bodily fluids and excretions, such as urine, blood, blood serum, amniotic fluid, spinal fluid, conjunctival fluid, salivary fluid, vaginal fluid, stool, seminal fluid, and sweat to be carried out with greater sensitivity. The masking agents are suppressed by contacting a test sample with an amount of one...

대표
청구항
▼

What is claimed is: 1. A method of suppressing the interference of a masking agent selected from the group consisting of a leukocyte esterase, a heme protein, a myoglobin analogue, a hemoglobin analogue, a myoglobin derivative, a hemoglobin derivative, a myoglobin oxidation product, a hemoglobin oxidation product, a myoglobin breakdown product, a hemoglobin breakdown product, a ferritin, methemoglobin, sulfhemoglobin, and bilirubin, on a molecular assay of a nucleic acid-containing bodily fluid, the method comprising: contacting the bodily fluid with a ...

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